This randomized clinical trial compares the efficacy of 4 oral combination analgesics among adult patients treated for moderate to severe acute extremity pain at 2 urban emergency departments in the United States.
This study uses data from the 2013 US Disease Expenditure project and the 2015 Global Burden of Disease study to evaluate associations between population, disease, and service utilization and price variables and changes in health care spending between 1996 and 2013.
This pharmacoepidemiology study conducted in France assesses the risk of lymphoma associated with thiopurines and anti–tumor necrosis factor agents, used alone or in combination, for treatment of inflammatory bowel disease.
This network meta-analysis of trials comparing fall-prevention interventions for older adults provides summary estimates of the effects of exercise and vision and environmental assessments for reducing fall-related injury and hospitalization.
This study compares ingredients listed on the labels of cannabidiol products sold online to actual product constituents determined by laboratory analysis.
This study characterizes discrepancies between primary outcomes specified in trial protocols, registrations, and publications, and the association between prospective registration and consistency of published outcomes.
This Viewpoint reviews the potential health risks associated with fracking in the United States, including effects on air quality and consequences of exposure to fracking fluids, and proposes policy and public health safeguards to prevent harms.
This Viewpoint reviews the development of immune checkpoint inhibitors as a new drug class for treating cancer, and discusses future directions including development of commercial assays for identifying response-to-treatment biomarkers and the use of combination regimens to improve response.
This Viewpoint discusses how precision medicine demands case-based reasoning, in which the relevant particulars of the individual patient are elucidated and incorporated into clinical assessments and decisions, and the challenge of expanding individualized knowledge.
This Viewpoint examines strategies for vaccinating travelers against yellow fever given recent vaccine shortages and global yellow fever outbreaks.
This Clinical Evidence Synopsis summarizes a Cochrane review summarizing associations between maternal use of antiepileptic drugs during pregnancy and major congenital malformations in children.
This JAMA Clinical Guidelines Synopsis summarizes the 2017 Global Initiative for Chronic Obstructive Lung Disease guideline on screening for chronic obstructive pulmonary disorder.
A comprehensive urine drug screen for a 50-year-old woman taking daily methadone, immediate-release morphine, gabapentin, duloxetine, and celecoxib for pain was positive for methadone and morphine but also codeine and hydromorphone. How do you interpret the results?
This Medical News article explores the prospects for gene editing in humans.
This Arts and Medicine essay features portrait paintings of individuals whose health care stories represent the challenges of navigating the fragmented US health care and insurance system.
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