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March 2023 - July 1883




November 7, 2017, Vol 318, No. 17, Pages 1625-1728

In This Issue of JAMA


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JAMA. 2017;318(17):1625-1627. doi:10.1001/jama.2016.13377
Original Investigation

Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial

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JAMA. 2017;318(17):1661-1667. doi:10.1001/jama.2017.16190

This randomized clinical trial compares the efficacy of 4 oral combination analgesics among adult patients treated for moderate to severe acute extremity pain at 2 urban emergency departments in the United States.

Factors Associated With Increases in US Health Care Spending, 1996-2013

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JAMA. 2017;318(17):1668-1678. doi:10.1001/jama.2017.15927

This study uses data from the 2013 US Disease Expenditure project and the 2015 Global Burden of Disease study to evaluate associations between population, disease, and service utilization and price variables and changes in health care spending between 1996 and 2013.

Association Between Use of Thiopurines or Tumor Necrosis Factor Antagonists Alone or in Combination and Risk of Lymphoma in Patients With Inflammatory Bowel Disease

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JAMA. 2017;318(17):1679-1686. doi:10.1001/jama.2017.16071

This pharmacoepidemiology study conducted in France assesses the risk of lymphoma associated with thiopurines and anti–tumor necrosis factor agents, used alone or in combination, for treatment of inflammatory bowel disease.

Comparisons of Interventions for Preventing Falls in Older Adults: A Systematic Review and Meta-analysis

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JAMA. 2017;318(17):1687-1699. doi:10.1001/jama.2017.15006

This network meta-analysis of trials comparing fall-prevention interventions for older adults provides summary estimates of the effects of exercise and vision and environmental assessments for reducing fall-related injury and hospitalization.

Research Letter

Labeling Accuracy of Cannabidiol Extracts Sold Online

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JAMA. 2017;318(17):1708-1709. doi:10.1001/jama.2017.11909

This study compares ingredients listed on the labels of cannabidiol products sold online to actual product constituents determined by laboratory analysis.

Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications

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JAMA. 2017;318(17):1709-1711. doi:10.1001/jama.2017.13001

This study characterizes discrepancies between primary outcomes specified in trial protocols, registrations, and publications, and the association between prospective registration and consistency of published outcomes.


Potential Health Implications Related to Fracking

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JAMA. 2017;318(17):1645-1646. doi:10.1001/jama.2017.14239

This Viewpoint reviews the potential health risks associated with fracking in the United States, including effects on air quality and consequences of exposure to fracking fluids, and proposes policy and public health safeguards to prevent harms.

Targeting Immune Checkpoints in Cancer Therapy

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JAMA. 2017;318(17):1647-1648. doi:10.1001/jama.2017.14155

This Viewpoint reviews the development of immune checkpoint inhibitors as a new drug class for treating cancer, and discusses future directions including development of commercial assays for identifying response-to-treatment biomarkers and the use of combination regimens to improve response.

Knowledge for Precision Medicine: Mechanistic Reasoning and Methodological Pluralism

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JAMA. 2017;318(17):1649-1650. doi:10.1001/jama.2017.11914

This Viewpoint discusses how precision medicine demands case-based reasoning, in which the relevant particulars of the individual patient are elucidated and incorporated into clinical assessments and decisions, and the challenge of expanding individualized knowledge.

Vaccination Challenges in Confronting the Resurgent Threat From Yellow Fever

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JAMA. 2017;318(17):1651-1652. doi:10.1001/jama.2017.14258

This Viewpoint examines strategies for vaccinating travelers against yellow fever given recent vaccine shortages and global yellow fever outbreaks.

A Piece of My Mind

Despite My Best Intentions

Abstract Full Text
JAMA. 2017;318(17):1653-1654. doi:10.1001/jama.2017.6123

Opioid vs Nonopioid Acute Pain Management in the Emergency Department

Abstract Full Text
JAMA. 2017;318(17):1655-1656. doi:10.1001/jama.2017.16725

Factors Associated With Increased US Health Care Spending: Implications for Controlling Health Care Costs

Abstract Full Text
JAMA. 2017;318(17):1657-1658. doi:10.1001/jama.2017.16802

Evidence Supports Action to Prevent Injurious Falls in Older Adults

Abstract Full Text
JAMA. 2017;318(17):1659-1660. doi:10.1001/jama.2017.15098
JAMA Clinical Evidence Synopsis

Maternal Use of Antiepileptic Agents During Pregnancy and Major Congenital Malformations in Children

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JAMA. 2017;318(17):1700-1701. doi:10.1001/jama.2017.14485

This Clinical Evidence Synopsis summarizes a Cochrane review summarizing associations between maternal use of antiepileptic drugs during pregnancy and major congenital malformations in children.

JAMA Clinical Guidelines Synopsis

Screening for Chronic Obstructive Pulmonary Disease

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JAMA. 2017;318(17):1702-1703. doi:10.1001/jama.2017.15782

This JAMA Clinical Guidelines Synopsis summarizes the 2017 Global Initiative for Chronic Obstructive Lung Disease guideline on screening for chronic obstructive pulmonary disorder.

JAMA Diagnostic Test Interpretation

Interpretation of Urine Drug Screens: Metabolites and Impurities

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JAMA. 2017;318(17):1704-1705. doi:10.1001/jama.2017.10910

A comprehensive urine drug screen for a 50-year-old woman taking daily methadone, immediate-release morphine, gabapentin, duloxetine, and celecoxib for pain was positive for methadone and morphine but also codeine and hydromorphone. How do you interpret the results?

Medical News & Perspectives

Bioethics Panels Open Door Slightly to Germline Gene Editing

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JAMA. 2017;318(17):1639-1640. doi:10.1001/jama.2017.13962

This Medical News article explores the prospects for gene editing in humans.

News From the Food and Drug Administration

First Biosimilar to Treat Cancer

Abstract Full Text
JAMA. 2017;318(17):1644. doi:10.1001/jama.2017.15839

Duodenoscope Design Aimed at Infection Prevention

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JAMA. 2017;318(17):1644. doi:10.1001/jama.2017.16043

Intravenous Lymphoma Drug Approved

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JAMA. 2017;318(17):1644. doi:10.1001/jama.2017.16047
The JAMA Forum

Republicans Will Own Whatever Happens to the ACA and Health Care Reform

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JAMA. 2017;318(17):1642-1643. doi:10.1001/jama.2017.15727
Bench to Bedside

Gene Editing Provides Clues to Why Cancer Immunotherapy Often Fails

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JAMA. 2017;318(17):1641-1642. doi:10.1001/jama.2017.15507
The Arts and Medicine

Portraits in Health Policy

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JAMA. 2017;318(17):1634-1636. doi:10.1001/jama.2017.11556

This Arts and Medicine essay features portrait paintings of individuals whose health care stories represent the challenges of navigating the fragmented US health care and insurance system.

Poetry and Medicine

Rituximab / Bendamustine

Abstract Full Text
JAMA. 2017;318(17):1717. doi:10.1001/jama.2017.3106
JAMA Revisited

Care of the Aged: Malford W. Thewlis, M.D., Wakefield, R. I.

Abstract Full Text
JAMA. 2017;318(17):1721. doi:10.1001/jama.2017.10493
JAMA Patient Page


Abstract Full Text
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JAMA. 2017;318(17):1728. doi:10.1001/jama.2017.15764
Comment & Response

Alendronate and Hip Fracture in Patients Using Glucocorticoids

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JAMA. 2017;318(17):1711-1712. doi:10.1001/jama.2017.14291

Alendronate and Hip Fracture in Patients Using Glucocorticoids—Reply

Abstract Full Text
JAMA. 2017;318(17):1712. doi:10.1001/jama.2017.14295

Challenges in Implementing Personalized Care Planning

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JAMA. 2017;318(17):1713. doi:10.1001/jama.2017.14254

Challenges in Implementing Personalized Care Planning—Reply

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JAMA. 2017;318(17):1713-1714. doi:10.1001/jama.2017.14261

Persistence of Penicillin Allergy

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JAMA. 2017;318(17):1714. doi:10.1001/jama.2017.13740

Persistence of Penicillin Allergy—Reply

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JAMA. 2017;318(17):1714-1715. doi:10.1001/jama.2017.13763
JAMA Masthead


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JAMA. 2017;318(17):1629-1630. doi:10.1001/jama.2016.13378