This randomized clinical trial compares the effects of sertraline vs placebo on depressive symptoms in patients with stage 3, 4, or 5 non–dialysis-dependent chronic kidney disease and major depressive disorder.
This randomized trial tests the effects of oral insulin on time to new-onset type 1 diabetes in relatives of patients with type 1 diabetes with autoantibodies or impaired glucose tolerance..
This randomized clinical trial determines whether indwelling pleural catheters are more effective than talc pleurodesis in reducing total hospitalization days in the remaining lifespan of patients with malignant pleural effusion.
This systematic review evaluates the performance of a cardiac troponin I threshold of 5 ng/L at presentation as a risk stratification tool in patients with suspected acute coronary syndrome.
This health services epidemiology study uses National Electronic Injury Surveillance System database data to characterize trends in hospital emergency department visits for nonfatal self-inflicted injuries among US youth aged 10 to 24 years from 2001 through 2015.
This Viewpoint discusses how a clinical information commons, a health care system’s database of all its patient-based data, could make genetically based clinical diagnoses more scientific and potentially improve patient outcomes.
This Viewpoint uses FDA approval of tisagenlecleucel, the first chimeric antigen receptor T-cell (CAR-T) agent approved for human use, to discuss escalating drug prices for oncology therapies and the complex considerations of outcomes and value that should justify the pricing.
This Viewpoint proposes a new Affordability Index measure, the ratio of the mean cost of an employer-sponsored family health insurance policy divided by median household income, to describe US families’ ability to pay for health care.
This Viewpoint discusses the Centers for Medicare & Medicaid Services’ Accountable Health Communities project to test the role of community integrators—organizations within a community that can represent its needs and engage stakeholders to work toward improvements in health—as a possible mechanism to decrease life expectancy disparities across the United States.
In this essay, the author describes his experience as an amputee to urge physicians to consider the whole patients beyond their disabilities as a way of building confidence that they can contribute and make a difference.
This JAMA Guide to Statistics and Methods reviews the concepts underlying mendelian randomization and provides examples of its application to clinical trial design.
This commentary on a research letter published in JAMA Internal Medicine comparing the quality of care at Veterans Affairs (VA) vs non-VA hospitals discusses the systems the VA has in place to improve the health care of patients.
This Medical Letter review summarizes the composition and dosing of commercially available pancreatic enzyme replacement products used to improve digestion in patients with exocrine pancreatic insufficiency.
This Medical News article discusses the health implications of loneliness and interventions to build emotional support.
This JAMA Patient Page summarizes the most common food allergies and the immunotherapy options available for desensitization to food allergens.