This randomized clinical trial tested the effect of targeted temperature management to 33°C for 48 hours vs 24 hours on neurologic outcomes at 6 months in survivors of out-of-hospital cardiac arrest.
This randomized clinical trial assesses the effectiveness of a nursing quality improvement intervention and a mobile health messaging intervention separately and combined to promote infant safe sleep practices compared with control breastfeeding interventions in mothers of healthy term newborns at 16 US hospitals.
This case series investigated the neuropathological and clinical features of deceased football players with chronic traumatic encephalopathy whose brains were donated for research.
This analysis evaluates the potential causal association between genetic variants related to elevated serum calcium levels and risk of coronary artery disease and myocardial infarction using mendelian randomization.
This study uses commercial pharmaceutical database data to evaluate the number of new drugs and vaccines for neglected tropical diseases entering phase 1 clinical trials before and after introduction in 2007 of a priority review voucher program to incentivize development.
This Viewpoint uses the example of power morcellator devices to discuss the wider scope of US Food and Drug Administration regulations and postmarketing surveillance necessary to ensure patient safety.
This Viewpoint uses the example of gastric band failures to discuss how available data may be used more appropriately to detect problems in the safety and effectiveness of medical devices.
This Viewpoint argues for rescission of legal mandates requiring contact precautions for any patient with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) infection in favor and more selective and cost-effective infection control measures.
This JAMA Insights article explains process of cascade screening for familial hypercholesterolemia and its efficacy in reducing risk of atherosclerotic cardiovascular disease.
A 42-year-old man had epistaxis and spontaneous ecchymoses of the extremities. A complete blood cell count and coagulation profile showed abnormalities, and a peripheral blood smear showing promyelocytes with bilobed nuclei and azurophilic cytoplasmic granules. What would you do next?
A 29-year-old woman with chronic paroxysmal palpitations, flushing, paleness, and diaphoresis had a blood pressure of 112/74 mm Hg, a heart rate of 82 beats/min, normal physical examination, and normal plasma metanephrines with elevated normetanephrines. How do you interpret the results?
This Medical News article discusses how new inner ear research may lead to treatments that reverse hearing loss.
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