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January 2022 - July 1883




August 1, 2017, Vol 318, No. 5, Pages 403-490

In This Issue of JAMA


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JAMA. 2017;318(5):403-405. doi:10.1001/jama.2016.13245
Original Investigation

Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial

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JAMA. 2017;318(5):432-442. doi:10.1001/jama.2017.9362

This randomized clinical trial evaluated the effectiveness and safety of oral methylprednisolone vs placebo in patients with IgA nephropathy and proteinuria.

Effect of Endovascular Contact Aspiration vs Stent Retriever on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion: The ASTER Randomized Clinical Trial

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JAMA. 2017;318(5):443-452. doi:10.1001/jama.2017.9644

This randomized trial compares the effects of thrombectomy with a contact aspiration vs a stent retriever technique on successful endovascular revascularization in patients with acute ischemic stroke.

Association of Practice-Level Social and Medical Risk With Performance in the Medicare Physician Value-Based Payment Modifier Program

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JAMA. 2017;318(5):453-461. doi:10.1001/jama.2017.9643

This cross-sectional study assesses whether physician practices serving more socially high-risk and medically high-risk patients are associated with performance in the Medicare Physician Value-Based Payment Modifier Program.

Research Letter

Fees for Certification and Finances of Medical Specialty Boards

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JAMA. 2017;318(5):477-479. doi:10.1001/jama.2017.7464

This study investigates fees charged to physicians for certification examinations and finances of the American Board of Medical Specialties member boards.


Treatment of Cholesterol in 2017

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JAMA. 2017;318(5):417-418. doi:10.1001/jama.2017.6753

This Viewpoint clarifies 3 treatment options for treating patients with elevated cholesterol levels by discussing patient goals, encouraging lifestyle changes, and using lipid-lowering medication.

Inconsistent Guideline Recommendations for Cardiovascular Prevention and the Debate About Zeroing in on and Zeroing LDL-C Levels With PCSK9 Inhibitors

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JAMA. 2017;318(5):419-420. doi:10.1001/jama.2017.6765

This Viewpoint discusses variances in cardiovascular prevention guidelines from the United States, Europe, and Canada and the debate surrounding low-density lipoprotein levels as the primary focus.

Marshaling FDA Benefit-Risk Expertise to Address the Current Opioid Abuse Epidemic

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JAMA. 2017;318(5):421-422. doi:10.1001/jama.2017.9205

In this Viewpoint, FDA Commissioner Scott Gottlieb and CDER Director Janet Woodcock discuss how the FDA weighs the risks and benefits of opioids and integrates public health and clinical perspectives into decisions about opioid approval, marketing, restrictions, and labeling.

Both Urgency and Balance Needed in Addressing Opioid Epidemic: A Report From the National Academies of Sciences, Engineering, and Medicine

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JAMA. 2017;318(5):423-424. doi:10.1001/jama.2017.10046

This Viewpoint describes the National Academies of Sciences, Engineering, and Medicine’s new report on the harms associated with opioid misuse and the effects of strategies to reduce those harms, and discusses the importance of balancing patients’ pain management and addressing the current opioid epidemic.

New Data on Opioid Use and Prescribing in the United States

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JAMA. 2017;318(5):425-426. doi:10.1001/jama.2017.8913

This Viewpoint from the acting director of the CDC and coauthors reports data on opioid prescribing and related misuse and overdose-related deaths for the period 2006-2015 in the United States.

A Piece of My Mind

The Paradox of Mindfulness: Seamus Heaney’s “St Kevin and the Blackbird”

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JAMA. 2017;318(5):427-428. doi:10.1001/jama.2017.6164

Corticosteroids for IgA Nephropathy: TESTING for Benefit, Discovering Harm

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JAMA. 2017;318(5):429-431. doi:10.1001/jama.2017.9359
The Rational Clinical Examination

Does This Child Have Pneumonia?The Rational Clinical Examination Systematic Review

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JAMA. 2017;318(5):462-471. doi:10.1001/jama.2017.9039

This systematic review analyzes 23 cohort studies to assess the accuracy of individual symptoms and physical examination findings for the diagnosis of radiographic pneumonia in children.

From the JAMA Network

Viral Testing for Pediatric Respiratory Infections: Why Precise Diagnoses Do Not Always Translate to Patient Benefit

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JAMA. 2017;318(5):472-473. doi:10.1001/jama.2017.3985

This commentary discusses a narrative review published in JAMA Pediatrics that summarized the rationale historically used to support respiratory viral testing in children and the potential considerations and limitations of the various types of tests.

JAMA Diagnostic Test Interpretation

24-Hour Urine Calcium in the Evaluation and Management of Nephrolithiasis

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JAMA. 2017;318(5):474-475. doi:10.1001/jama.2017.7085

A 29-year-old man presented with recurrent nephrolithiasis with 95% calcium oxalate and 5% calcium phosphate. His maternal family history was significant for nephrolithiasis, but his laboratory studies showed normal results. How would you proceed?

Medical News & Perspectives

Pilot Programs Seek to Integrate Genomic Data Into Practice

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JAMA. 2017;318(5):410-412. doi:10.1001/jama.2017.7181

This Medical News article discusses recent programs and initiatives aimed at better integrating genomic data into clinical practice.

News From the Food and Drug Administration

New Hereditary Angioedema Therapy

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JAMA. 2017;318(5):416. doi:10.1001/jama.2017.9334

Another Fluoroquinolone Approved

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JAMA. 2017;318(5):416. doi:10.1001/jama.2017.9336

Extended-Release ADHD Drug

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JAMA. 2017;318(5):416. doi:10.1001/jama.2017.9338
The JAMA Forum

State Flexibility for Medicaid: How Much?

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JAMA. 2017;318(5):413-414. doi:10.1001/jama.2017.8758
Bench to Bedside

CRISPR-Based System Uncovers Key Regulators of Disease-Related Genes

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JAMA. 2017;318(5):412-413. doi:10.1001/jama.2017.9216
JAMA Infographic

Visualizing Health Policy

Costs and Outcomes of Mental Health and Substance Use Disorders in the US

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JAMA. 2017;318(5):415. doi:10.1001/jama.2017.8558
Poetry and Medicine

Michael Jackson’s Skin

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JAMA. 2017;318(5):485. doi:10.1001/jama.2017.4229
JAMA Revisited

Medical News: London Letter

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JAMA. 2017;318(5):486. doi:10.1001/jama.2017.8599
JAMA Patient Page

Childhood Pneumonia

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JAMA. 2017;318(5):490. doi:10.1001/jama.2017.9428
Comment & Response

Dexmedetomidine in Patients With Sepsis Requiring Mechanical Ventilation

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JAMA. 2017;318(5):479-480. doi:10.1001/jama.2017.7853

Dexmedetomidine in Patients With Sepsis Requiring Mechanical Ventilation—Reply

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JAMA. 2017;318(5):480. doi:10.1001/jama.2017.7869

Exercise for Patients With Hypertrophic Cardiomyopathy

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JAMA. 2017;318(5):480-481. doi:10.1001/jama.2017.8193

Exercise for Patients With Hypertrophic Cardiomyopathy—Reply

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JAMA. 2017;318(5):481-482. doi:10.1001/jama.2017.8201

Risks of Medical Metaphors

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JAMA. 2017;318(5):482. doi:10.1001/jama.2017.8197

Risks of Medical Metaphors—Reply

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JAMA. 2017;318(5):482-483. doi:10.1001/jama.2017.8205

Time to Diagnostic Testing After a Positive Colorectal Cancer Screening Test

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JAMA. 2017;318(5):483. doi:10.1001/jama.2017.9312

Time to Diagnostic Testing After a Positive Colorectal Cancer Screening Test—Reply

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JAMA. 2017;318(5):483-484. doi:10.1001/jama.2017.9316
JAMA Masthead


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JAMA. 2017;318(5):407-408. doi:10.1001/jama.2016.13246