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November 2020 - July 1883




August 22/29, 2017, Vol 318, No. 8, Pages 677-764

In This Issue of JAMA


Abstract Full Text
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JAMA. 2017;318(8):677-679. doi:10.1001/jama.2016.13278
Original Investigation

Effect of Natriuretic Peptide–Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2017;318(8):713-720. doi:10.1001/jama.2017.10565

This randomized clinical trial investigates whether reducing natriuretic peptide levels by titrating medication to reach the target of less than 1000 pg/mL in patients with heart failure and reduced ejection fraction improves clinical outcomes.

Effect of Oral Prednisolone on Symptom Duration and Severity in Nonasthmatic Adults With Acute Lower Respiratory Tract Infection: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2017;318(8):721-730. doi:10.1001/jama.2017.10572

This randomized trial compares the effect of prednisolone vs placebo on duration of moderately bad or worse cough and severity of symptoms in nonasthmatic adults with acute lower respiratory infections.

Preliminary Communication

Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2017;318(8):731-740. doi:10.1001/jama.2017.10569

This randomized clinical trial examines whether ganciclovir prophylaxis reduces plasma interleukin 6 levels in cytomegalovirus-seropositive adults who are critically ill.

Research Letter

Updated Cost-effectiveness Analysis of PCSK9 Inhibitors Based on the Results of the FOURIER Trial

Abstract Full Text
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JAMA. 2017;318(8):748-750. doi:10.1001/jama.2017.9924

This study uses the results of the FOURIER trial to assess the current cost-effectiveness of PCSK9 inhibitors over the lifetime analytic horizon for patients with atherosclerotic cardiovascular disease in the United States.

Medication-Assisted Treatment and Opioid Use Before and After Overdose in Pennsylvania Medicaid

Abstract Full Text
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JAMA. 2017;318(8):750-752. doi:10.1001/jama.2017.7818

This study uses Medicaid data to compare prescription opioid use, duration of opioid use, and rates of medication-assisted treatment (buprenorphine, methadone, or naltrexone) among enrollees before and after an overdose event.


What Is Medicaid? More Than Meets the Eye

Abstract Full Text
JAMA. 2017;318(8):695-696. doi:10.1001/jama.2017.10304

This Viewpoint summarizes the main features of the Medicaid program and how proposed legislation might affect it.

Maintenance of Certification and Texas SB 1148: A Threat to Professional Self-regulation

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JAMA. 2017;318(8):697-698. doi:10.1001/jama.2017.10127

This Viewpoint discusses Texas’ 2017 Senate Bill 1148, which restricts the use of maintenance of board certification as a credential for hospital privileging, and implications of the legislation for physician self-regulation.

Gene Editing Using CRISPR: Why the Excitement?

Abstract Full Text
JAMA. 2017;318(8):699-700. doi:10.1001/jama.2017.10159

This Viewpoint discusses the gene-editing technique CRISPR, explaining how it works, its discovery, its limitations, and how it could potentially be used in biological research and medical practice.

Time for Transparent Standards in Quality Reporting by Health Care Organizations

Abstract Full Text
JAMA. 2017;318(8):701-702. doi:10.1001/jama.2017.10124

This Viewpoint calls for truthful, timely, and transparent public reports on quality measures and suggests that such reports be linked to those developed by the Centers for Medicare & Medicaid Services or the LeapFrog Group.

Multidimensional Evidence Generation and FDA Regulatory Decision Making: Defining and Using “Real-World” Data

Abstract Full Text
JAMA. 2017;318(8):703-704. doi:10.1001/jama.2017.9991

This Viewpoint discusses the potential to expand the application of “real-world evidence” from pragmatically designed studies in US Food and Drug Administration regulatory efforts.

A Piece of My Mind

Underprivilege as Privilege

Abstract Full Text
JAMA. 2017;318(8):705-706. doi:10.1001/jama.2017.9425

Biomarker-Guided vs Guideline-Directed Titration of Medical Therapy for Heart Failure

Abstract Full Text
JAMA. 2017;318(8):707-708. doi:10.1001/jama.2017.10540

Time to Consider Cytomegalovirus Prevention in Critically Ill Patients?

Abstract Full Text
JAMA. 2017;318(8):709-710. doi:10.1001/jama.2017.10132

PCSK9 Inhibitors and the Choice Between Innovation, Efficiency, and Affordability

Abstract Full Text
JAMA. 2017;318(8):711-712. doi:10.1001/jama.2017.8907
From the JAMA Network

Endogenous Fungal Endophthalmitis: An Increasing Problem Among Intravenous Drug Users

Abstract Full Text
JAMA. 2017;318(8):741-742. doi:10.1001/jama.2017.10585

This commentary discusses a case series published in JAMA Ophthalmology describing 10 patients with intravenous drug use who developed and underwent treatment for endogenous fungal endophthalmitis.

JAMA Clinical Guidelines Synopsis

Treatment of Low Back Pain

Abstract Full Text
JAMA. 2017;318(8):743-744. doi:10.1001/jama.2017.9386

This JAMA Clinical Guidelines Synopsis summarizes the 2017 American College of Physicians’ guideline on noninvasive treatments for acute, subacute, and chronic low back pain.

JAMA Diagnostic Test Interpretation

Screening for Depression

Abstract Full Text
JAMA. 2017;318(8):745-746. doi:10.1001/jama.2017.9820

A 57-year-old man presented with a history of HIV, hyperlipidemia, and major depressive disorder reporting depression and insomnia. He was taking bupropion but recent life events led to increased depressive symptoms. How would you proceed?

Medical News & Perspectives

An International Human Cell Atlas Consortium Takes Shape

Abstract Full Text
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JAMA. 2017;318(8):685-686. doi:10.1001/jama.2017.5640

This Medical News article discusses a project to map all cell types and states in the human body.

The JAMA Forum

Why It’s So Hard for Insurers to Compete Over Technology

Abstract Full Text
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JAMA. 2017;318(8):687-688. doi:10.1001/jama.2017.9971
News From the Centers for Disease Control and Prevention

Racial Disparities Remain in Breastfeeding Rates

Abstract Full Text
JAMA. 2017;318(8):691. doi:10.1001/jama.2017.10454

Professional Jobs Linked With ALS and Parkinson Disease Deaths

Abstract Full Text
JAMA. 2017;318(8):691. doi:10.1001/jama.2017.10459
Clinical Trials Update

Home Monitoring Fails to Improve Glycemic Control

Abstract Full Text
JAMA. 2017;318(8):690. doi:10.1001/jama.2017.10991

Exercise Therapy Offers Modest Benefits for Chronic Fatigue

Abstract Full Text
JAMA. 2017;318(8):690. doi:10.1001/jama.2017.10993

Stereotactic Radiotherapy Is Superior for Benign Brain Tumors

Abstract Full Text
JAMA. 2017;318(8):690. doi:10.1001/jama.2017.10995

Recombinant Influenza Vaccine More Effective in Older Adults

Abstract Full Text
JAMA. 2017;318(8):690. doi:10.1001/jama.2017.10997

Olaparib Increased Survival in Metastatic Breast Cancer

Abstract Full Text
JAMA. 2017;318(8):690. doi:10.1001/jama.2017.9824
Health Agencies Update

Even the Eye Has a Microbiome

Abstract Full Text
JAMA. 2017;318(8):689. doi:10.1001/jama.2017.10599

Vaccines Protect Fetus From Zika

Abstract Full Text
JAMA. 2017;318(8):689. doi:10.1001/jama.2017.11200

Open Access Data Tool for Cancer Research

Abstract Full Text
JAMA. 2017;318(8):689. doi:10.1001/jama.2017.11202
Poetry and Medicine

Listen to Your Body

Abstract Full Text
JAMA. 2017;318(8):757. doi:10.1001/jama.2017.2926
JAMA Revisited

Vaccine Treatment Again

Abstract Full Text
JAMA. 2017;318(8):758. doi:10.1001/jama.2017.9460
JAMA Patient Page

Groin Hernia Repair by Open Surgery

Abstract Full Text
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JAMA. 2017;318(8):764. doi:10.1001/jama.2017.9868
Comment & Response

Dexamethasone Without Antibiotics for Sore Throat

Abstract Full Text
JAMA. 2017;318(8):752-753. doi:10.1001/jama.2017.8663

Dexamethasone Without Antibiotics for Sore Throat

Abstract Full Text
JAMA. 2017;318(8):753. doi:10.1001/jama.2017.8667

Dexamethasone Without Antibiotics for Sore Throat—Reply

Abstract Full Text
JAMA. 2017;318(8):753-754. doi:10.1001/jama.2017.8671

Water Exchange to Facilitate Unsedated Colonoscopy

Abstract Full Text
JAMA. 2017;318(8):754. doi:10.1001/jama.2017.9987

Water Exchange to Facilitate Unsedated Colonoscopy—Reply

Abstract Full Text
JAMA. 2017;318(8):754-755. doi:10.1001/jama.2017.9994

Bias Among Peer Reviewers

Abstract Full Text
JAMA. 2017;318(8):755. doi:10.1001/jama.2017.9186

Bias Among Peer Reviewers

Abstract Full Text
JAMA. 2017;318(8):755-756. doi:10.1001/jama.2017.9201
JAMA Masthead


Abstract Full Text
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JAMA. 2017;318(8):681-682. doi:10.1001/jama.2016.13279