This randomized clinical trial investigates whether reducing natriuretic peptide levels by titrating medication to reach the target of less than 1000 pg/mL in patients with heart failure and reduced ejection fraction improves clinical outcomes.
This randomized trial compares the effect of prednisolone vs placebo on duration of moderately bad or worse cough and severity of symptoms in nonasthmatic adults with acute lower respiratory infections.
This randomized clinical trial examines whether ganciclovir prophylaxis reduces plasma interleukin 6 levels in cytomegalovirus-seropositive adults who are critically ill.
This study uses the results of the FOURIER trial to assess the current cost-effectiveness of PCSK9 inhibitors over the lifetime analytic horizon for patients with atherosclerotic cardiovascular disease in the United States.
This study uses Medicaid data to compare prescription opioid use, duration of opioid use, and rates of medication-assisted treatment (buprenorphine, methadone, or naltrexone) among enrollees before and after an overdose event.
This Viewpoint summarizes the main features of the Medicaid program and how proposed legislation might affect it.
This Viewpoint discusses Texas’ 2017 Senate Bill 1148, which restricts the use of maintenance of board certification as a credential for hospital privileging, and implications of the legislation for physician self-regulation.
This Viewpoint discusses the gene-editing technique CRISPR, explaining how it works, its discovery, its limitations, and how it could potentially be used in biological research and medical practice.
This Viewpoint calls for truthful, timely, and transparent public reports on quality measures and suggests that such reports be linked to those developed by the Centers for Medicare & Medicaid Services or the LeapFrog Group.
This Viewpoint discusses the potential to expand the application of “real-world evidence” from pragmatically designed studies in US Food and Drug Administration regulatory efforts.
This commentary discusses a case series published in JAMA Ophthalmology describing 10 patients with intravenous drug use who developed and underwent treatment for endogenous fungal endophthalmitis.
This JAMA Clinical Guidelines Synopsis summarizes the 2017 American College of Physicians’ guideline on noninvasive treatments for acute, subacute, and chronic low back pain.
A 57-year-old man presented with a history of HIV, hyperlipidemia, and major depressive disorder reporting depression and insomnia. He was taking bupropion but recent life events led to increased depressive symptoms. How would you proceed?
This Medical News article discusses a project to map all cell types and states in the human body.