This randomized noninferiority trial compares the effect of mechanically expanded vs self-expanding transcatheter aortic valve replacement (TAVR) on mortality and major adverse clinical events in patients with aortic stenosis at high or extreme risk of adverse outcomes.
This randomized clinical trial tested the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children.
This study uses Scientific Registry of Transplant Recipients registry data to compare kidney transplantation rates among white, black, Hispanic, and Asian recipient candidates in 1995-1999 vs 2010-2014.
This study estimates the current prevalence of autism spectrum disorder among US children and adolescents from 2014 to 2016 using nationally representative data from the National Health Interview Survey.
In this Viewpoint, Victor Fuchs discusses the prospects that a single-payer health system can solve the 3 principal problems that bedevil US health care: the uninsured, poor outcomes, and high costs.
In this Viewpoint, David Naylor reviews the many differences between the United States and Canada that preclude the Canadian single-payer system from being a useful exemplar for US health reform.
In this Viewpoint, Verghese and colleagues discuss the promise and challenges of integrating artificial intelligence (AI) into clinical care and argue that AI will always need guidance by physicians if it is to improve the care of patients.
This Viewpoint uses the legal dispute between Amgen and the US Food and Drug Administration (FDA) regarding the FDA’s denial of market exclusivity for cinacalcet to discuss the FDA policy granting 6 months of market exclusivity as an incentive for manufacturers to conduct efficacy and safety studies in child populations.
In this essay, the author ponders how his 70-year-old patient’s need to tell his story before talking about his own health care needs reminds him of the necessity of listening to patients to know them enough to provide precise care.
This narrative review summarizes the epidemiology and pathophysiology of sepsis, management of post-sepsis sequelae in the months following hospital discharge, and directions for future research to reduce long-term sequelae and improve patient recovery.
This commentary discusses a cohort study published in JAMA Otolaryngology–Head & Neck Surgery examining the probability, rate, and magnitude of tumor growth in patients with papillary thyroid cancer during active surveillance.
A 59-year-old African American woman had a rapidly enlarging, nonfluctuant, noninflamed nodule with central ulceration on one finger. She had no history of hand trauma, joint pain, stiffness, or lymphadenopathy; results of a recent complete blood cell count and comprehensive metabolic profile were unremarkable. What would you do next?
This Medical News story discusses recent breakthroughs in the long fight against multiple sclerosis.
This JAMA Patient Page describes common long-term health problems associated with sepsis as well as management of postsepsis care.