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January 2023 - July 1883




January 2, 2018, Vol 319, No. 1, Pages 1-91

In This Issue of JAMA


Abstract Full Text
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JAMA. 2018;319(1):1-3. doi:10.1001/jama.2017.12174
Original Investigation

Effect of Mechanically Expanded vs Self-Expanding Transcatheter Aortic Valve Replacement on Mortality and Major Adverse Clinical Events in High-Risk Patients With Aortic Stenosis: The REPRISE III Randomized Clinical Trial

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JAMA. 2018;319(1):27-37. doi:10.1001/jama.2017.19132

This randomized noninferiority trial compares the effect of mechanically expanded vs self-expanding transcatheter aortic valve replacement (TAVR) on mortality and major adverse clinical events in patients with aortic stenosis at high or extreme risk of adverse outcomes.

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial

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JAMA. 2018;319(1):38-48. doi:10.1001/jama.2017.19826

This randomized clinical trial tested the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children.

Association of Race and Ethnicity With Live Donor Kidney Transplantation in the United States From 1995 to 2014

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JAMA. 2018;319(1):49-61. doi:10.1001/jama.2017.19152

This study uses Scientific Registry of Transplant Recipients registry data to compare kidney transplantation rates among white, black, Hispanic, and Asian recipient candidates in 1995-1999 vs 2010-2014.

Research Letter

Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016

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JAMA. 2018;319(1):81-82. doi:10.1001/jama.2017.17812

This study estimates the current prevalence of autism spectrum disorder among US children and adolescents from 2014 to 2016 using nationally representative data from the National Health Interview Survey.


Is Single Payer the Answer for the US Health Care System?

Abstract Full Text
JAMA. 2018;319(1):15-16. doi:10.1001/jama.2017.18739

In this Viewpoint, Victor Fuchs discusses the prospects that a single-payer health system can solve the 3 principal problems that bedevil US health care: the uninsured, poor outcomes, and high costs.

Canada as Single-Payer Exemplar for Universal Health Care in the United States: A Borderline Option

Abstract Full Text
JAMA. 2018;319(1):17-18. doi:10.1001/jama.2017.19668

In this Viewpoint, David Naylor reviews the many differences between the United States and Canada that preclude the Canadian single-payer system from being a useful exemplar for US health reform.

What This Computer Needs Is a Physician: Humanism and Artificial Intelligence

Abstract Full Text
JAMA. 2018;319(1):19-20. doi:10.1001/jama.2017.19198

In this Viewpoint, Verghese and colleagues discuss the promise and challenges of integrating artificial intelligence (AI) into clinical care and argue that AI will always need guidance by physicians if it is to improve the care of patients.

Pediatric Exclusivity and Regulatory Authority: Implications of Amgen v HHS

Abstract Full Text
JAMA. 2018;319(1):21-22. doi:10.1001/jama.2017.16477

This Viewpoint uses the legal dispute between Amgen and the US Food and Drug Administration (FDA) regarding the FDA’s denial of market exclusivity for cinacalcet to discuss the FDA policy granting 6 months of market exclusivity as an incentive for manufacturers to conduct efficacy and safety studies in child populations.

A Piece of My Mind

The Envelope

Abstract Full Text
JAMA. 2018;319(1):23. doi:10.1001/jama.2017.19273

In this essay, the author ponders how his 70-year-old patient’s need to tell his story before talking about his own health care needs reminds him of the necessity of listening to patients to know them enough to provide precise care.


Disparities in Live Donor Kidney Transplantation: Related to Poverty, Race, or Ethnicity?

Abstract Full Text
JAMA. 2018;319(1):24-26. doi:10.1001/jama.2017.19617

Enhancing Recovery From Sepsis: A Review

Abstract Full Text
JAMA. 2018;319(1):62-75. doi:10.1001/jama.2017.17687

This narrative review summarizes the epidemiology and pathophysiology of sepsis, management of post-sepsis sequelae in the months following hospital discharge, and directions for future research to reduce long-term sequelae and improve patient recovery.

From the JAMA Network

Expanding the Options for Patient-Guided Decision Making in Papillary Thyroid Cancer

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JAMA. 2018;319(1):76-77. doi:10.1001/jama.2017.18608

This commentary discusses a cohort study published in JAMA Otolaryngology–Head & Neck Surgery examining the probability, rate, and magnitude of tumor growth in patients with papillary thyroid cancer during active surveillance.

JAMA Clinical Challenge

A Woman With a Large Ulcerated Nodule on the Finger

Abstract Full Text
JAMA. 2018;319(1):78-79. doi:10.1001/jama.2017.19282

A 59-year-old African American woman had a rapidly enlarging, nonfluctuant, noninflamed nodule with central ulceration on one finger. She had no history of hand trauma, joint pain, stiffness, or lymphadenopathy; results of a recent complete blood cell count and comprehensive metabolic profile were unremarkable. What would you do next?

Medical News & Perspectives

New Inroads Against Multiple Sclerosis

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JAMA. 2018;319(1):9-11. doi:10.1001/jama.2017.14033

This Medical News story discusses recent breakthroughs in the long fight against multiple sclerosis.

News From the Food and Drug Administration

Digital Pill Gains Approval

Abstract Full Text
JAMA. 2018;319(1):14. doi:10.1001/jama.2017.19309

Opioid Withdrawal Symptoms Subside With Cranial Nerve Stimulation

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JAMA. 2018;319(1):14. doi:10.1001/jama.2017.19313

Treatment for Rare Enzyme Disorder

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JAMA. 2018;319(1):14. doi:10.1001/jama.2017.20058
The JAMA Forum

Housing as Health

Abstract Full Text
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JAMA. 2018;319(1):12-13. doi:10.1001/jama.2017.20081
Bench to Bedside

Smart Artificial Beta Cells May Help Treat Diabetes

Abstract Full Text
JAMA. 2018;319(1):11-12. doi:10.1001/jama.2017.12856
Poetry and Medicine

Love’s Muse

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JAMA. 2018;319(1):87. doi:10.1001/jama.2017.10501
JAMA Revisited

Hamstringing the Army

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JAMA. 2018;319(1):88. doi:10.1001/jama.2017.12182
JAMA Patient Page

Postsepsis Morbidity

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JAMA. 2018;319(1):91. doi:10.1001/jama.2017.19809

This JAMA Patient Page describes common long-term health problems associated with sepsis as well as management of postsepsis care.

Comment & Response

Recurrence of Reflux After Laparoscopic Antireflux Surgery

Abstract Full Text
JAMA. 2018;319(1):82-83. doi:10.1001/jama.2017.17712

Self-regulation of the Medical Profession and Maintenance of Certification

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JAMA. 2018;319(1):83-84. doi:10.1001/jama.2017.17699

Recurrence of Reflux After Laparoscopic Antireflux Surgery—Reply

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JAMA. 2018;319(1):83. doi:10.1001/jama.2017.17728

Self-regulation of the Medical Profession and Maintenance of Certification

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JAMA. 2018;319(1):84. doi:10.1001/jama.2017.17708

Self-regulation of the Medical Profession and Maintenance of Certification—Reply

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JAMA. 2018;319(1):84-85. doi:10.1001/jama.2017.17720

The Nuremberg Code and Informed Consent for Research

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JAMA. 2018;319(1):85-86. doi:10.1001/jama.2017.17704

The Nuremberg Code and Informed Consent for Research—Reply

Abstract Full Text
JAMA. 2018;319(1):86. doi:10.1001/jama.2017.17724
JAMA Masthead


Abstract Full Text
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JAMA. 2018;319(1):5-6. doi:10.1001/jama.2017.12175