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March 2023 - July 1883




March 27, 2018, Vol 319, No. 12, Pages 1177-1290

In This Issue of JAMA


Abstract Full Text
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JAMA. 2018;319(12):1177-1179. doi:10.1001/jama.2017.12295
Original Investigation

Estimated 24-Hour Urinary Sodium and Potassium Excretion in US Adults

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JAMA. 2018;319(12):1209-1220. doi:10.1001/jama.2018.1156

This study uses NHANES data to estimate the mean population sodium intake and describe urinary potassium excretion among US adults aged 20 to 69 years.

Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis

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JAMA. 2018;319(12):1221-1238. doi:10.1001/jama.2018.1896

This network meta-analysis of randomized trials compares the efficacy and safety of indomethacin, ibuprofen, and acetaminophen for closure of clinically or echocardiographically diagnosed hemodynamically significant patent ductus arteriosus (PDA) in preterm infants.

Association Between Loss of Hospital-Based Obstetric Services and Birth Outcomes in Rural Counties in the United States

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JAMA. 2018;319(12):1239-1247. doi:10.1001/jama.2018.1830

This cohort study investigates the association between loss of hospital-based obstetric services between 2004 and 2014 and changes in location of childbirth and preterm births in rural counties in the United States.

Trends and Patterns of Differences in Infectious Disease Mortality Among US Counties, 1980-2014

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JAMA. 2018;319(12):1248-1260. doi:10.1001/jama.2018.2089

This population epidemiology study estimates county-level patterns in mortality rates from infectious diseases in the United States between 1980 and 2014.

Research Letter

Three-Year Follow-up of a Trial of Close Contact Casting vs Surgery for Initial Treatment of Unstable Ankle Fractures in Older Adults

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JAMA. 2018;319(12):1274-1276. doi:10.1001/jama.2018.0811

This study reports 3-year outcomes of a randomized trial that compared close contact casting vs the usual surgery for unstable ankle fractures in older adults and that found equivalent ankle function outcomes at 6 months.

Electronic Health Record Usability Issues and Potential Contribution to Patient Harm

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JAMA. 2018;319(12):1276-1278. doi:10.1001/jama.2018.1171

This study analyzed patient safety reports in and near Pennsylvania from 2013 through 2016 to identify those that contained explicit language associating possible patient harm with an electronic health record usability issue.


A Path to Sustain Rural Hospitals

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JAMA. 2018;319(12):1193-1194. doi:10.1001/jama.2018.2967

This Viewpoint discusses the rationale and policy objectives of the Pennsylvania Rural Health Model, a program launched by CMS and the Commonwealth of Pennsylvania in 2017 to transition rural hospitals from fee-for-service reimbursement to a multipayer global budget payment method intended to improve population health outcomes and quality of care while lowering costs.

Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States

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JAMA. 2018;319(12):1195-1196. doi:10.1001/jama.2018.0126

This Viewpoint summarizes findings from a population-based birth defect surveillance report from the Centers for Disease Control and Prevention estimating the prevalence of birth defects potentially related to Zika virus infection in US areas with documented local Zika virus transmission in 2016.

Preventing the Malignant Transformation of Bipolar Disorder

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JAMA. 2018;319(12):1197-1198. doi:10.1001/jama.2018.0322

This Viewpoint argues that the therapeutic approach to bipolar disorder should mimic that for cancer, with immediate aggressive treatment and vigilant monitoring and follow-up to prevent long-term sequelae of disability, cognitive deficits, and suicide.

A Piece of My Mind

Mentoring in the Era of #MeToo

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JAMA. 2018;319(12):1199-1200. doi:10.1001/jama.2018.2128

In this narrative essay, the author wonders what effect the #metoo phenomenon will have on mentoring between male mentors and junior female trainees and faculty and recalls male mentors who were supportive of her and other women colleagues’ professional development in a plea for diversity and inclusion among leaders in medicine that supports the entire academic medical community.


Measurements of 24-Hour Urinary Sodium and Potassium Excretion: Importance and Implications

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JAMA. 2018;319(12):1201-1202. doi:10.1001/jama.2018.1153

Eroding Access and Quality of Childbirth Care in Rural US Counties

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JAMA. 2018;319(12):1203-1204. doi:10.1001/jama.2018.1646

Infectious Diseases Mortality in the United States: Ongoing Investment Needed for Continued Progress

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JAMA. 2018;319(12):1205-1206. doi:10.1001/jama.2018.1525

From Guideline to Order Set to Patient Harm

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JAMA. 2018;319(12):1207-1208. doi:10.1001/jama.2018.1666

HIV Preexposure Prophylaxis: A Review

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JAMA. 2018;319(12):1261-1268. doi:10.1001/jama.2018.1917

This narrative review summarizes evidence on the use of tenofovir disoproxil fumarate (TDF)/emtricitabine for HIV preexposure prophylaxis (PrEP) and calls for increased prescribing of PrEP and research on measures to identify individuals at high risk for HIV to ensure their access to PrEP and maximize medication adherence.

JAMA Performance Improvement

β-Blockers in Myocardial Infarction: Issues With Standard Admission Order Sets

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JAMA. 2018;319(12):1269-1270. doi:10.1001/jama.2018.0845

This JAMA Performance Improvement article uses the case of a patient with acute myocardial infarction and heart failure who developed cardiogenic shock after being given carvedilol as part of a standard STEMI admission order set to discuss the limits of orders sets and of guideline-based care and the need to optimize each for individual patient circumstances.

JAMA Diagnostic Test Interpretation

Gastroesophageal Reflux Monitoring

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JAMA. 2018;319(12):1271-1272. doi:10.1001/jama.2018.1144

A 56-year-old woman with persistent GERD symptoms on 40 mg esomeprazole had a normal EGD and 24-hour ambulatory reflux monitoring results. What would you do next?

Medical News & Perspectives

Postmenopausal Women With a “Normal” BMI Might Be Overweight or Even Obese

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JAMA. 2018;319(12):1185-1187. doi:10.1001/jama.2018.0423

This Medical News article examines why BMI-based definitions of overweight and obese might misclassify postmenopausal women as normal weight.

The JAMA Forum

How the Economy Affects Health

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JAMA. 2018;319(12):1187-1188. doi:10.1001/jama.2018.1739
News From the Centers for Disease Control and Prevention

Drug-Resistant Infections from Raw Milk

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JAMA. 2018;319(12):1191. doi:10.1001/jama.2018.2363

Global Outbreaks Threaten US Economy

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JAMA. 2018;319(12):1191. doi:10.1001/jama.2018.2595
Clinical Trials Update

Similar IVF Birth Rates for Frozen and Fresh Embryos

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JAMA. 2018;319(12):1190. doi:10.1001/jama.2018.2150

Exercise Remodels Heart in Middle Age

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JAMA. 2018;319(12):1190. doi:10.1001/jama.2018.2786

Benefits of Moderate Physical Activity Despite Frailty

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JAMA. 2018;319(12):1190. doi:10.1001/jama.2018.2789

Brief Psychotherapy for PTSD

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JAMA. 2018;319(12):1190. doi:10.1001/jama.2018.2791
Health Agencies Update

NIH Releases Data from Large Adolescent Brain Study

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JAMA. 2018;319(12):1189. doi:10.1001/jama.2018.2352

VA Announces Plan to Improve Worst-Performing Medical Centers

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JAMA. 2018;319(12):1189. doi:10.1001/jama.2018.2784

CMS to Improve Drug Programs and Opioid Overuse Oversight

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JAMA. 2018;319(12):1189. doi:10.1001/jama.2018.2785
Poetry and Medicine

Total Eclipse

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JAMA. 2018;319(12):1282. doi:10.1001/jama.2017.14331
JAMA Revisited

Legislation for Increased Rank for Medical Officers

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JAMA. 2018;319(12):1283. doi:10.1001/jama.2017.12303
JAMA Patient Page


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JAMA. 2018;319(12):1290. doi:10.1001/jama.2018.0749

This JAMA Patient Page describes hypothermia, its prevention, and treatment strategies.

Comment & Response

Genotype vs Clinically Guided Dosing of Warfarin to Prevent Adverse Events

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JAMA. 2018;319(12):1278-1279. doi:10.1001/jama.2018.0189

Genotype vs Clinically Guided Dosing of Warfarin to Prevent Adverse Events—Reply

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JAMA. 2018;319(12):1279-1280. doi:10.1001/jama.2018.0195

Vaccination Strategies During Shortages of Yellow Fever Vaccine

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JAMA. 2018;319(12):1280. doi:10.1001/jama.2018.0200

Vaccination Strategies During Shortages of Yellow Fever Vaccine—Reply

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JAMA. 2018;319(12):1280-1281. doi:10.1001/jama.2018.0232

Table and Figure Errors

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JAMA. 2018;319(12):1281. doi:10.1001/jama.2018.2301
JAMA Masthead


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JAMA. 2018;319(12):1181-1182. doi:10.1001/jama.2017.12296