In this study, Global Burden of Disease investigators characterize trends in mortality, life expectancy, and prevalence associated with most common diseases and disease and mortality risk factors in the United States between 1990 and 2016.
This systematic review and meta-analysis assesses the effects of long-acting muscarinic antagonist vs placebo or vs other controllers as an add-on therapy to inhaled corticosteroids and the use of triple therapy vs inhaled corticosteroids and long-acting β-agonists in patients with uncontrolled, persistent asthma.
This systematic review and meta-analysis of randomized trials compares the efficacy of combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as the controller and the quick relief therapy (SMART) vs the same or higher doses of inhaled corticosteroids with or without a LABA used as the controller therapy and short-acting β-agonists as the relief therapy in patients with persistent asthma.
This survey study assesses the health and nutritional status of Rohingya children aged 6 to 59 months in the Kutupalong refugee camp in Bangladesh.
In this Viewpoint, John Ioannidis discusses the potential effects on clinical research of a 2017 proposal to lower the default P value threshold for statistical significance from .05 to .005 as a means to reduce false-positive findings and reviews alternative solutions for improving the accuracy and relevance of statistical inference.
In this Viewpoint, Anthony Fauci and colleagues review modern technological advances that facilitate acceleration of vaccine development in response to new and emerging viral disease threats, and argue for investment in surveillance in developing countries to expedite pathogen identification and jump-start the vaccine development process.
This Viewpoint reviews evidence that cannabis use impairs driving performance and emphasizes the importance of developing policies and legislation to address the resulting safety risks.
This Viewpoint describes the 2018 rescission of federal limits on enforcement of medical marijuana and discusses its possible consequences on state laws, medical research, and legal risks for physicians prescribing and patients using medical marijuana.
In this narrative medical essay, the author recounts a patient’s brave decision to refuse a face mask and mechanical ventilation while deoxygenating from spontaenous pneumothorax and interstitial lung disease, a care choice none of the physicians considered.
This Genomics and Precision Health article reviews clinical applications of tumor DNA sequencing to direct treatment of melanoma and of myeloid, lung, and colorectal cancers.
An African American man presented with a 5-year history of a pruritic and painful rash of the right lateral area of the neck and right axilla that worsened in the summer and sometimes blistered. A sister had a similar rash. What would you do next?
This Medical Letter review summarizes the mechanism of action, results from clinical studies, and adverse effects of benralizumab, a humanized monoclonal antibody selective for the interleukin-5 receptor, for add-on maintenance treatment of severe asthma among patients aged 12 years or older with an eosinophilic phenotype .
This Medical News article profiles Beth Toppins, an emergency physician on the front lines of the opioid epidemic in Huntington, West Virginia. It is part of an ongoing JAMA News series profiling the daily routine of health care professionals making a difference in their communities.
This Medical News article discusses whether trehalose, a sugar manufactured from cornstarch used to sweeten and texturize foods, has contributed to the emergence of epidemic strains of Clostridium difficile infection (CDI).
This JAMA Patient Page describes the medications used to treat asthma.