This randomized clinical trial compares the effects of true vs sham acupuncture on live births among women undergoing assisted reproduction with in vitro fertilization.
This randomized clinical trial compares the effect of a monthly vs a single dose of fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide, on monthly migraine days in patients with episodic migraine.
This pharmacoepidemiology study uses 1999-2014 NHANES data to characterize trends in use of prescription medications among children and adolescents aged 0 to 19 years in the United States.
This cohort study of participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer randomized clinical trial compares long-term CRC incidence between individuals with either advanced or nonadvanced adenomas compared with those with no adenomas.
This study analyzes National Health Interview Survey data to characterize changes in electronic cigarette use among US adults in 2014-2016.
This Viewpoint reviews the growth of the Choosing Wisely campaign from its inception in 2012 into an international movement and outlines advances in evidence and implementation that will be necessary for the effort to have more widespread, durable effects on the quality, safety, and value of health care.
This Viewpoint points out that many definitions of low-value health care are based exclusively on efficacy or harm, and argues that inclusion of cost and cost-effectiveness measures is necessary to define health service value.
This Viewpoint summarizes a 2017 NASEM Roundtable on Genomics and Precision Health that shared experiences of US health systems with use of genome sequencing for clinical and research applications and that explored how the sequencing programs might advance models for data sharing and collaborative implementation research; generate evidence regarding the benefits, harms, and value of precision medicine; and reduce disparities through partnerships with diverse populations.
In this Viewpoint, John Ioannidis and colleagues discuss the challenges and potential benefits of defining what is “healthy” in an era of precision medicine, when defining normal will require that each person be assigned to an increasingly narrow and granular reference population.
In this narrative medicine essay, a pediatrician recounts his struggle to work through his family’s beliefs about marriage and children and his own commitments to science exemplified by Darwin’s theory of natural selection as he and his husband began a family using an egg donor and in vitro fertilization.
This JAMA Clinical Guidelines Synopsis summarizes the American College of Cardiology (ACC) Foundation’s 2017 consensus guideline on management of bleeding in patients taking oral anticoagulants.
A 64-year-old man with a family history of early-onset lung disease, presented with dyspnea and recurrent pneumonia, emphysema changes on CT, and a serum α1-antitrypsin concentration of 14 mg/dL. How would you interpret the result?
This Medical Letter review summarizes labeling requirements, effectiveness, and availability of new abuse-deterrent opioids approved by the US Food and Drug Administration.
This Medical News Story discusses the effectiveness of posting calories and other nutrition information on restaurant menus.
This Medical News story describes mounting evidence that shows a Mediterranean diet rich in plant-based foods may reduce older adults’ risk of becoming frail.
This JAMA Patient Page describes the causes and types of angioedema and its symptoms, prevention, and treatment.
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