This report describes findings from 3 randomized trials comparing the cognitive effects of 10, 30, or 60 mg/d of idalopirdine added to stable cholinesterase inhibitor treatment or placebo for symptomatic treatment of mild to moderate Alzheimer disease.
This cohort study uses Canadian administrative health care data to investigate associations between handover of intraoperative anesthesia care between one physician and another and risk of adverse postoperative outcomes among patients undergoing major surgery.
This simulation study estimates reductions in breast cancer mortality associated with screening and treatment by estrogen-receptor and human epidermal growth factor receptor 2 (ERBB2) status.
This study describes hospital participation and dropout in the Centers for Medicare & Medicaid Innovation’s Bundled Payments for Care Improvement Initiative, which allows hospitals and practices to retain savings if they meet quality targets.
This Recommendation Statement from the US Preventive Services Task Force concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for adolescent idiopathic scoliosis in children and adolescents aged 10 to 18 years (I statement).
This systematic review to support the 2018 update of the US Preventive Services Task Force Recommendation Statement on screening for adolescent idiopathic scoliosis (AIS) summarizes published evidence on the benefits and harms of AIS screening and treatment for children and adolescents aged 10 to 18 years.
In this Viewpoint, John Ioannidis discusses implications of the 2017 hypertension guidelines for real-world management of blood pressure (BP), including labeling healthy people as having disease and possible adverse treatment effects at lower BP treatment targets..
This Viewpoint discusses practical applications of the recent 2017 ACC?AHA guidelines on hypertension management and the importance of emphasizing healthier lifestyles in the United States.
This Viewpoint discusses reforms to federal funding strategies and systems that might incentivize health care delivery innovation and create learning health care systems focused on improving health more than financial outcomes.
In this humanities essay, a former combat medic recalls an encounter with a patient whose smile and calm demeanor belied acute physical signs of torture.
This Medical Letter review summarizes the mechanism of action and adverse effects of combination lesinurad, an uric acid transporter 1, and allopurinol, a xanthine oxidase inhibitor, for treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels with allopurinol alone.
This Medical News article discusses data on American Indian and Alaska Native premature mortality and its causes.
This JAMA Patient Page discusses the US Preventive Services Task Force’s recommendations on screening for adolescent idiopathic scoliosis.
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