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May 2023 - July 1883




June 19, 2018, Vol 319, No. 23, Pages 2349-2450

In This Issue of JAMA


Abstract Full Text
free access has audio
JAMA. 2018;319(23):2349-2351. doi:10.1001/jama.2017.12416
Original Investigation

Association of Stress-Related Disorders With Subsequent Autoimmune Disease

Abstract Full Text
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JAMA. 2018;319(23):2388-2400. doi:10.1001/jama.2018.7028

This cohort study uses Swedish national registry data to investigate associations between PTSD, stress reactions, and adjustment disorders and subsequent autoimmune disease.

Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer

Abstract Full Text
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JAMA. 2018;319(23):2401-2409. doi:10.1001/jama.2018.6228

This case-control study uses Mayo Clinic registry data to assess associations between inherited germline mutations in 21 cancer predisposition genes and risk of pancreatic cancer.

Differences in Obesity Prevalence by Demographics and Urbanization in US Children and Adolescents, 2013-2016

Abstract Full Text
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JAMA. 2018;319(23):2410-2418. doi:10.1001/jama.2018.5158

This national survey study uses NHANES data to examine trends in obesity and severe obesity among US youth aged 2 to 19 years by sex, age, race and ethnicity, education level, and urbanization from 2013 to 2016.

Differences in Obesity Prevalence by Demographic Characteristics and Urbanization Level Among Adults in the United States, 2013-2016

Abstract Full Text
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JAMA. 2018;319(23):2419-2429. doi:10.1001/jama.2018.7270

This national survey study uses National Health and Nutrition Examination Survey data to examine trends in obesity and severe obesity among adults aged 20 years or older by age, sex, race, ethnicity, education level and urbanization level between 2001 and 2016.

Research Letter

Representation of Patients With Chronic Kidney Disease in Trials of Cancer Therapy

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JAMA. 2018;319(23):2437-2439. doi:10.1001/jama.2018.7260

This study characterizes the exclusion of patients with chronic kidney disease (CKD) in randomized clinical trials of drug treatment for bladder, breast, colorectal, lung, and prostate cancer.


An Incomplete Prescription: President Trump’s Plan to Address High Drug Prices

Abstract Full Text
JAMA. 2018;319(23):2373-2374. doi:10.1001/jama.2018.7424

This Viewpoint discusses missed opportunities in the 2018 White House blueprint to reduce prescription drug prices, including a proposal that would require CMS to negotiate prices with manufacturers and that would ban unfair practices companies use to extend brand exclusivity.

Banning Abortion in Cases of Down Syndrome: Important Lessons for Advances in Genetic Diagnosis

Abstract Full Text
JAMA. 2018;319(23):2375-2376. doi:10.1001/jama.2018.6118

This Viewpoint discusses legal and ethical issues raised by the 2017 Ohio law prohibiting physicians from performing abortions if the pregnant woman’s decision was influenced by her belief that the fetus has Down syndrome.

Direct-to-Consumer Genetic Testing: The Implications of the US FDA’s First Marketing Authorization for BRCA Mutation Testing

Abstract Full Text
JAMA. 2018;319(23):2377-2378. doi:10.1001/jama.2018.5330

This Viewpoint discusses the implications of the US FDA’s 2018 marketing authorization permitting 23and Me to market BRCA mutation testing to the general public, including concern about overtesting, false assurance, and the ability of accessible testing to improve population health outcomes.

Evolving Payer Coverage Policies on Genomic Sequencing Tests: Beginning of the End or End of the Beginning?

Abstract Full Text
JAMA. 2018;319(23):2379-2380. doi:10.1001/jama.2018.4863

This Viewpoint discusses a 2018 Centers for Medicare & Medicaid Services national coverage determination on next-generation sequencing tests for patients with advanced cancer and suggests ways to ensure appropriate and equitable access to testing, resource efficiency, and improvement in patient and societal outcomes.

The Microbiome and Risk for Atherosclerosis

Abstract Full Text
JAMA. 2018;319(23):2381-2382. doi:10.1001/jama.2018.5240

This Viewpoint discusses the role the human gut microbiome may play in the development and progression of atherosclerosis, both by influencing risk factors and by direct effects on the inflammation and vulnerability of endovascular plaques.

A Piece of My Mind

The Perfect Specialty

Abstract Full Text
JAMA. 2018;319(23):2386-2387. doi:10.1001/jama.2018.7132

In this narrative medicine essay, an internist speculates about the perfect specialty in moments of confusion over nonspecified illnesses and concludes that all specialties involve scientific imprecision.


Germline Genetic Testing for Pancreatic Ductal Adenocarcinoma at Time of Diagnosis

Abstract Full Text
JAMA. 2018;319(23):2383-2385. doi:10.1001/jama.2018.6227
JAMA Clinical Guidelines Synopsis

Glycemic Control in Nonpregnant Adults With Type 2 Diabetes

Abstract Full Text
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JAMA. 2018;319(23):2430-2431. doi:10.1001/jama.2018.6798

This JAMA Clinical Guidelines Synopsis summarizes the American College of Physicians’ (ACP’s) 2018 guidance statement on hemoglobin A1c goals in nonpregnant adults with type 2 diabetes.

JAMA Clinical Challenge

A Mediastinal Mass in a Young Man

Abstract Full Text
JAMA. 2018;319(23):2432-2433. doi:10.1001/jama.2018.7107

A healthy young adult presented to the emergency department reporting 6 months of fatigue, dry cough, dyspnea, and weight loss. A chest x-ray showed opacification of the right lung field and a CT revealed a centrally necrotic mass in the right anterior mediastinum, right pleural effusion, and compression of the superior vena cava. What would you do next?

From The Medical Letter on Drugs and Therapeutics

Ertugliflozin for Type 2 Diabetes

Abstract Full Text
JAMA. 2018;319(23):2434-2435. doi:10.1001/jama.2018.5840

This Medical Letter review summarizes clinical study data, adverse effects, drug interactions, and dosage and administration of the sodium-glucose co-transporter 2 inhibitor ertugliflozin alone and in fixed-dose combinations with metformin for the treatment of adults with type 2 diabetes.

Medical News & Perspectives

A Day in the Life: Physician Cares for HIV-Positive Patients in Jail

Abstract Full Text
JAMA. 2018;319(23):2365-2367. doi:10.1001/jama.2018.5315

This Medical News story describes a day in the life of an infectious disease specialist caring for incarcerated individuals living with HIV.

For Patients With Type 2 Diabetes, What’s the Best Target Hemoglobin A1C?

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JAMA. 2018;319(23):2367-2369. doi:10.1001/jama.2018.5420

This Medical News article discusses new clinical guidance for blood glucose targets.

News From the Food and Drug Administration

New Relief for Opioid Withdrawal

Abstract Full Text
JAMA. 2018;319(23):2372. doi:10.1001/jama.2018.7719

Neurovascular Stent Caution

Abstract Full Text
JAMA. 2018;319(23):2372. doi:10.1001/jama.2018.7721

Biosimilar Approved for Anemia

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JAMA. 2018;319(23):2372. doi:10.1001/jama.2018.7764
The JAMA Forum

The Need to Simplify Measuring Quality in Health Care

Abstract Full Text
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JAMA. 2018;319(23):2369-2370. doi:10.1001/jama.2018.6858
Global Health

Ethical Guidelines for Genomic Research in Africa

Abstract Full Text
JAMA. 2018;319(23):2371. doi:10.1001/jama.2018.7241

New Platform Showcases Scientific Research From Africa

Abstract Full Text
JAMA. 2018;319(23):2371. doi:10.1001/jama.2018.7853

Preemptive Antibiotic Use Reduces Childhood Deaths

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JAMA. 2018;319(23):2371. doi:10.1001/jama.2018.7854
The Arts and Medicine

Pathogenesis: A New Deck-Building Game

Abstract Full Text
JAMA. 2018;319(23):2364. doi:10.1001/jama.2018.1770

This Arts and Medicine essay reviews Pathogenesis, a deck-building card game in which players accumulate cards that represent the battle between microbial pathogens and the body’s physical defense barriers and adaptive and innate immune responses.

Poetry and Medicine


Abstract Full Text
JAMA. 2018;319(23):2444. doi:10.1001/jama.2017.21352
JAMA Revisited

The Early History of Bacteriology in the United States

Abstract Full Text
JAMA. 2018;319(23):2445. doi:10.1001/jama.2017.12424
JAMA Patient Page


Abstract Full Text
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JAMA. 2018;319(23):2450. doi:10.1001/jama.2018.6514

This JAMA Patient Page describes the vasectomy procedure and follow-up practices.

Comment & Response

Motivation to Participate in PTSD Research

Abstract Full Text
JAMA. 2018;319(23):2439-2440. doi:10.1001/jama.2018.4326

Motivation to Participate in PTSD Research—Reply

Abstract Full Text
JAMA. 2018;319(23):2440-2441. doi:10.1001/jama.2018.4330

Bariatric Surgery and Hypertension

Abstract Full Text
JAMA. 2018;319(23):2441. doi:10.1001/jama.2018.4446

Bariatric Surgery and Hypertension—Reply

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JAMA. 2018;319(23):2441-2442. doi:10.1001/jama.2018.4470

Strategies to Prevent Obesity-Related Cancer

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JAMA. 2018;319(23):2442. doi:10.1001/jama.2018.4942

Strategies to Prevent Obesity-Related Cancer—Reply

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JAMA. 2018;319(23):2442-2443. doi:10.1001/jama.2018.4952

Incorrect Data in Abstract and Text

Abstract Full Text
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JAMA. 2018;319(23):2443. doi:10.1001/jama.2018.7453

Incorrect Data in Table Footnote and Text

Abstract Full Text
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JAMA. 2018;319(23):2443. doi:10.1001/jama.2018.7574
JAMA Masthead


Abstract Full Text
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JAMA. 2018;319(23):2353-2354. doi:10.1001/jama.2017.12417