This cohort study uses Swedish national registry data to investigate associations between PTSD, stress reactions, and adjustment disorders and subsequent autoimmune disease.
This case-control study uses Mayo Clinic registry data to assess associations between inherited germline mutations in 21 cancer predisposition genes and risk of pancreatic cancer.
This national survey study uses NHANES data to examine trends in obesity and severe obesity among US youth aged 2 to 19 years by sex, age, race and ethnicity, education level, and urbanization from 2013 to 2016.
This national survey study uses National Health and Nutrition Examination Survey data to examine trends in obesity and severe obesity among adults aged 20 years or older by age, sex, race, ethnicity, education level and urbanization level between 2001 and 2016.
This study characterizes the exclusion of patients with chronic kidney disease (CKD) in randomized clinical trials of drug treatment for bladder, breast, colorectal, lung, and prostate cancer.
This Viewpoint discusses missed opportunities in the 2018 White House blueprint to reduce prescription drug prices, including a proposal that would require CMS to negotiate prices with manufacturers and that would ban unfair practices companies use to extend brand exclusivity.
This Viewpoint discusses legal and ethical issues raised by the 2017 Ohio law prohibiting physicians from performing abortions if the pregnant woman’s decision was influenced by her belief that the fetus has Down syndrome.
This Viewpoint discusses the implications of the US FDA’s 2018 marketing authorization permitting 23and Me to market BRCA mutation testing to the general public, including concern about overtesting, false assurance, and the ability of accessible testing to improve population health outcomes.
This Viewpoint discusses a 2018 Centers for Medicare & Medicaid Services national coverage determination on next-generation sequencing tests for patients with advanced cancer and suggests ways to ensure appropriate and equitable access to testing, resource efficiency, and improvement in patient and societal outcomes.
This Viewpoint discusses the role the human gut microbiome may play in the development and progression of atherosclerosis, both by influencing risk factors and by direct effects on the inflammation and vulnerability of endovascular plaques.
In this narrative medicine essay, an internist speculates about the perfect specialty in moments of confusion over nonspecified illnesses and concludes that all specialties involve scientific imprecision.
This JAMA Clinical Guidelines Synopsis summarizes the American College of Physicians’ (ACP’s) 2018 guidance statement on hemoglobin A1c goals in nonpregnant adults with type 2 diabetes.
A healthy young adult presented to the emergency department reporting 6 months of fatigue, dry cough, dyspnea, and weight loss. A chest x-ray showed opacification of the right lung field and a CT revealed a centrally necrotic mass in the right anterior mediastinum, right pleural effusion, and compression of the superior vena cava. What would you do next?
This Medical Letter review summarizes clinical study data, adverse effects, drug interactions, and dosage and administration of the sodium-glucose co-transporter 2 inhibitor ertugliflozin alone and in fixed-dose combinations with metformin for the treatment of adults with type 2 diabetes.
This Medical News story describes a day in the life of an infectious disease specialist caring for incarcerated individuals living with HIV.
This Medical News article discusses new clinical guidance for blood glucose targets.
This Arts and Medicine essay reviews Pathogenesis, a deck-building card game in which players accumulate cards that represent the battle between microbial pathogens and the body’s physical defense barriers and adaptive and innate immune responses.
This JAMA Patient Page describes the vasectomy procedure and follow-up practices.