This randomized clinical trial compares the effects of fruquintinib, a vascular endothelial growth factor receptor (VEGFR) inhibitor, vs placebo on overall survival among patients with metastatic colorectal cancer whose disease progressed on treatment or who could not tolerate standard treatment because of toxic effects.
This study uses a national private insurance claims database data to compare abortion-related morbidity and adverse events among women undergoing induced abortions in office-based settings (including abortion clinics) vs ambulatory surgical centers.
This cohort study estimates population risk of major bleeding among community-dwelling people in New Zealand without cardiovascular disease (CVD) and not taking antiplatelet therapy in an attempt to define the harms associated with guidelines recommending aspirin for primary prevention of CVD.
This study uses National HIV Behavioral Surveillance survey data to estimate the proportion of men who have sex with men and persons who inject drugs unaware of their HIV infection who missed opportunities for testing and diagnosis in clinical settings.
This 2018 Recommendation Statement from the US Preventive Services Task Force recommends screening for osteoporosis with bone measurement testing to prevent osteoporotic fractures in women 65 years and older (B recommendation) and in postmenopausal women younger than 65 years at increased risk of osteoporosis (B recommendation), and concludes that current evidence is insufficient to assess the benefits and harms of screening to prevent osteoporotic fractures in men (I statement).
This systematic review to support the 2018 US Preventive Services Task Force Recommendation Statement on osteoporosis screening summarizes published evidence on the benefits and harms of screening and treatment to prevent osteoporotic fractures in adults 40 years and older.
This Viewpoint reviews the rationale for measuring health outcomes using quality-adjusted life-years (QALYs) and discusses the advantages and limitations of the measure and its role in attempts to define and promote the practice of high-value medicine.
This Viewpoint discusses the unique approach to health care reform implemented in Maryland, which has a diverse population served by rural, suburban, and urban hospitals including 2 major academic health centers.
This Viewpoint discusses the efforts India has been taking as it works toward establishing universal health coverage.
In this narrative medicine essay, an oncologist empathizes with a patient who upon learning that her cancer had returned asks about fertility preservation, a wish for children that mirrored the oncologists own desire for children after several miscarriages.
A Chinese woman developed fever, cervical lymphadenopathy, cytopenias, and elevated LFTs and ferritin levels, with a positive anti-dsDNA test and hemophagocytosis on bone marrow biopsy. What would you do next?
This Medical News article discusses how fears of rare adverse effects associated with osteoporosis medications are driving a treatment crisis.
This Medical News story examines why US infants continue to die because of unsafe sleep conditions.
This JAMA Patient Page describes the US Preventive Services Task Force recommendations on screening for osteoporosis to prevent fractures.
Create a personal account or sign in to: