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September 2020 - July 1883




March 6, 2018, Vol 319, No. 9, Pages 843-943

In This Issue of JAMA


Abstract Full Text
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JAMA. 2018;319(9):843-845. doi:10.1001/jama.2017.12262
Original Investigation

Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial

Abstract Full Text
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JAMA. 2018;319(9):872-882. doi:10.1001/jama.2018.0899

This randomized clinical trial compares the effects of opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and adverse effects among Veterans Affairs patients with moderate to severe chronic back pain or hip or knee osteoarthritis pain.

Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial

Abstract Full Text
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JAMA. 2018;319(9):883-895. doi:10.1001/jama.2018.0154

This cluster randomized trial evaluates the effect of a single prostate-specific antigen (PSA) screening test on 10-year prostate cancer–specific mortality among men aged 50 to 69 years treated at UK primary care practices.

Radical Prostatectomy, External Beam Radiotherapy, or External Beam Radiotherapy With Brachytherapy Boost and Disease Progression and Mortality in Patients With Gleason Score 9-10 Prostate Cancer

Abstract Full Text
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JAMA. 2018;319(9):896-905. doi:10.1001/jama.2018.0587

This cohort study compares mortality and disease progression in patients with Gleason score 9-10 (aggressive) prostate cancer treated with external beam radiotherapy plus androgen deprivation therapy, radiotherapy plus brachytherapy boost, or radical prostatectomy.

Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non–Vaccine-Targeted Infections From 24 Through 47 Months of Age

Abstract Full Text
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JAMA. 2018;319(9):906-913. doi:10.1001/jama.2018.0708

This nested case-control study compares cumulative vaccine antigen exposure through the first 23 months of life among children with vs without non–vaccine-targeted infections between 24 and 47 months of age.

Research Letter

Characteristics of Hospitals Earning Savings in the First Year of Mandatory Bundled Payment for Hip and Knee Surgery

Abstract Full Text
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JAMA. 2018;319(9):930-932. doi:10.1001/jama.2018.0678

This study uses Medicare data to compare the characteristics of hospitals that did vs did not realize episodes savings under the Centers for Medicare & Medicaid Services’ Comprehensive Care for Joint Replacement program, which bundled payments for hip and knee surgery and paid bonuses to hospitals that exceeded quality and cost benchmarks.


Vitamin and Mineral Supplements: What Clinicians Need to Know

Abstract Full Text
JAMA. 2018;319(9):859-860. doi:10.1001/jama.2017.21012

This Viewpoint reviews the evidence supporting use of specific vitamin and mineral supplements in healthy and high-risk populations, and provides general guidance about appropriate and inappropriate use of such supplements in generally healthy people.

Retreat From Human Rights and Adverse Consequences for Health

Abstract Full Text
JAMA. 2018;319(9):861-862. doi:10.1001/jama.2018.0271

This Viewpoint argues that a rise in attacks on health care facilities internationally is associated with the rise of authoritarian and far-right leaders, a general deterioration in mechanisms of domestic accountability, and a retreat of the international community from holding member governments accountable for adhering to basic human rights standards.

The Importance of Contact Precautions for Endemic Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci

Abstract Full Text
JAMA. 2018;319(9):863-864. doi:10.1001/jama.2017.21122

This Viewpoint discusses the importance of using gloves and gowns when caring for patients with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci despite the current lack of a strong clinical trial evidence base to support the practice.

Legal Challenges to State Drug Pricing Laws

Abstract Full Text
JAMA. 2018;319(9):865-866. doi:10.1001/jama.2017.20952

This Viewpoint discusses legislative efforts at the state level to monitor or regulate drug prices and reviews legal challenges raised by industry in response to these efforts.

A Piece of My Mind

A Ruse on Eternity

Abstract Full Text
JAMA. 2018;319(9):867. doi:10.1001/jama.2018.1106

When confronted with an infant with extreme microcephaly, the author in this essay remembers the life of a childhood friend’s older brother and idol who died overdosing inhalants at boarding school and resolves to trick the universe by adding more time for loved ones, patients, and colleagues.


Screening for Prostate Cancer: Is the Third Trial the Charm?

Abstract Full Text
JAMA. 2018;319(9):868-869. doi:10.1001/jama.2018.0153

Safety of Multiple Antigen Exposure in the Childhood Immunization Schedule

Abstract Full Text
JAMA. 2018;319(9):870-871. doi:10.1001/jama.2018.0891

The Diagnosis and Management of Thyroid Nodules: A Review

Abstract Full Text
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JAMA. 2018;319(9):914-924. doi:10.1001/jama.2018.0898

This Narrative Review article reports on the clinical management of patients with thyroid nodules.

JAMA Clinical Evidence Synopsis

Procalcitonin Testing to Guide Antibiotic Therapy in Acute Upper and Lower Respiratory Tract Infections

Abstract Full Text
JAMA. 2018;319(9):925-926. doi:10.1001/jama.2018.0852

This Clinical Evidence Synopsis summarizes a 2017 Cochrane review on procalcitonin testing to guide antibiotic therapy for patients with acute upper and lower respiratory tract infections.

JAMA Clinical Guidelines Synopsis

Peanut Allergy Prevention

Abstract Full Text
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JAMA. 2018;319(9):927-928. doi:10.1001/jama.2018.0449

This JAMA Clinical Guidelines Synopsis summarizes the 2016 National Institute of Allergy and Infectious Diseases guideline on peanut allergy prevention among infants.

Medical News & Perspectives

Clinicians Support Medical Marijuana Use in Children With Cancer, but Lack Knowledge

Abstract Full Text
JAMA. 2018;319(9):852-853. doi:10.1001/jama.2018.0089

This Medical News story discusses clinician attitudes towards medical marijuana use in children with cancer, and gaps in knowledge that pose barriers to its use in the clinic.

Do All Patients Need β-Blockers After a Heart Attack?

Abstract Full Text
JAMA. 2018;319(9):853-855. doi:10.1001/jama.2018.0107

This Medical News article discusses whether all patients really need β-blockers after a heart attack.

News From the Food and Drug Administration

First Radioactive Drug for Adults With Rare Cancer

Abstract Full Text
JAMA. 2018;319(9):857. doi:10.1001/jama.2018.1249

Scrutiny on Animal Research

Abstract Full Text
JAMA. 2018;319(9):857. doi:10.1001/jama.2018.1250

Crackdown on False Claims to Ease Opioid Withdrawal Symptoms

Abstract Full Text
JAMA. 2018;319(9):857. doi:10.1001/jama.2018.1252
Bench to Bedside

Scientists Separate Opioids’ Analgesic Effects From Their Dangerous Respiratory Effects

Abstract Full Text
JAMA. 2018;319(9):855-856. doi:10.1001/jama.2017.12858

This Medical News article discusses recent research findings that disentangles opioids analgesic effects from their dangerous respiratory effects.

The Arts and Medicine

The Humans in Health Care—A Review of The American Mercy Tour

Abstract Full Text
JAMA. 2018;319(9):850-851. doi:10.1001/jama.2018.0315

This Arts and Medicine reviews The American Mercy Tour, a traveling 2-act 1-man show created by Michael Milligan that dramatizes the stresses experienced by primary care physicians and patients in the US health care system.

Poetry and Medicine

Umbria Shook Today

Abstract Full Text
JAMA. 2018;319(9):937. doi:10.1001/jama.2017.13830
JAMA Revisited

The Health of Women Wage Earners

Abstract Full Text
JAMA. 2018;319(9):938. doi:10.1001/jama.2017.12270
JAMA Patient Page

Anaphylaxis in Children

Abstract Full Text
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JAMA. 2018;319(9):943. doi:10.1001/jama.2018.0447

This JAMA Patient Page discusses anaphylaxis symptoms, treatment, and avoidance measures in children.

Comment & Response

Lung Recruitment and Positive End-Expiratory Pressure Titration in Patients With Acute Respiratory Distress Syndrome

Abstract Full Text
JAMA. 2018;319(9):932-933. doi:10.1001/jama.2017.21856

Lung Recruitment and Positive End-Expiratory Pressure Titration in Patients With Acute Respiratory Distress Syndrome

Abstract Full Text
JAMA. 2018;319(9):933. doi:10.1001/jama.2017.21840

Lung Recruitment and Positive End-Expiratory Pressure Titration in Patients With Acute Respiratory Distress Syndrome

Abstract Full Text
JAMA. 2018;319(9):933-934. doi:10.1001/jama.2017.21844

Lung Recruitment and Positive End-Expiratory Pressure Titration in Patients With Acute Respiratory Distress Syndrome—Reply

Abstract Full Text
JAMA. 2018;319(9):934-935. doi:10.1001/jama.2017.21864

Patient Data Ownership

Abstract Full Text
JAMA. 2018;319(9):935. doi:10.1001/jama.2017.21672

Patient Data Ownership—Reply

Abstract Full Text
JAMA. 2018;319(9):935-936. doi:10.1001/jama.2017.21688
JAMA Masthead


Abstract Full Text
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JAMA. 2018;319(9):847-848. doi:10.1001/jama.2017.12263