This randomized clinical trial compares the effects of opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and adverse effects among Veterans Affairs patients with moderate to severe chronic back pain or hip or knee osteoarthritis pain.
This cluster randomized trial evaluates the effect of a single prostate-specific antigen (PSA) screening test on 10-year prostate cancer–specific mortality among men aged 50 to 69 years treated at UK primary care practices.
This cohort study compares mortality and disease progression in patients with Gleason score 9-10 (aggressive) prostate cancer treated with external beam radiotherapy plus androgen deprivation therapy, radiotherapy plus brachytherapy boost, or radical prostatectomy.
This nested case-control study compares cumulative vaccine antigen exposure through the first 23 months of life among children with vs without non–vaccine-targeted infections between 24 and 47 months of age.
This study uses Medicare data to compare the characteristics of hospitals that did vs did not realize episodes savings under the Centers for Medicare & Medicaid Services’ Comprehensive Care for Joint Replacement program, which bundled payments for hip and knee surgery and paid bonuses to hospitals that exceeded quality and cost benchmarks.
This Viewpoint reviews the evidence supporting use of specific vitamin and mineral supplements in healthy and high-risk populations, and provides general guidance about appropriate and inappropriate use of such supplements in generally healthy people.
This Viewpoint argues that a rise in attacks on health care facilities internationally is associated with the rise of authoritarian and far-right leaders, a general deterioration in mechanisms of domestic accountability, and a retreat of the international community from holding member governments accountable for adhering to basic human rights standards.
This Viewpoint discusses the importance of using gloves and gowns when caring for patients with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci despite the current lack of a strong clinical trial evidence base to support the practice.
This Viewpoint discusses legislative efforts at the state level to monitor or regulate drug prices and reviews legal challenges raised by industry in response to these efforts.
When confronted with an infant with extreme microcephaly, the author in this essay remembers the life of a childhood friend’s older brother and idol who died overdosing inhalants at boarding school and resolves to trick the universe by adding more time for loved ones, patients, and colleagues.
This Narrative Review article reports on the clinical management of patients with thyroid nodules.
This Clinical Evidence Synopsis summarizes a 2017 Cochrane review on procalcitonin testing to guide antibiotic therapy for patients with acute upper and lower respiratory tract infections.
This JAMA Clinical Guidelines Synopsis summarizes the 2016 National Institute of Allergy and Infectious Diseases guideline on peanut allergy prevention among infants.
This Medical News story discusses clinician attitudes towards medical marijuana use in children with cancer, and gaps in knowledge that pose barriers to its use in the clinic.
This Medical News article discusses whether all patients really need β-blockers after a heart attack.
This Medical News article discusses recent research findings that disentangles opioids analgesic effects from their dangerous respiratory effects.
This Arts and Medicine reviews The American Mercy Tour, a traveling 2-act 1-man show created by Michael Milligan that dramatizes the stresses experienced by primary care physicians and patients in the US health care system.
This JAMA Patient Page discusses anaphylaxis symptoms, treatment, and avoidance measures in children.
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