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September 2019 - July 1883




July 3, 2018, Vol 320, No. 1, Pages 3-102

In This Issue of JAMA


Abstract Full Text
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JAMA. 2018;320(1):3-5. doi:10.1001/jama.2017.12438
Original Investigation

Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial

Abstract Full Text
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JAMA. 2018;320(1):43-52. doi:10.1001/jama.2018.7464

This randomized clinical trial compares the effects of cervical HPV vs cytology (Pap smear) screening on the cumulative incidence of high-grade cervical intraepithelial neoplasia (CIN3+) detected at 48 months.

Association of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes

Abstract Full Text
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JAMA. 2018;320(1):53-62. doi:10.1001/jama.2018.7993

This pharmacoepidemiology study estimates the risk of hypoglycemia-related emergency department visits or hospital admissions associated with initiation of long-acting insulin analogs vs human neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes.

Association of the US Department of Justice Investigation of Implantable Cardioverter-Defibrillators and Devices Not Meeting the Medicare National Coverage Determination, 2007-2015

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JAMA. 2018;320(1):63-71. doi:10.1001/jama.2018.8151

This cross-sectional analysis uses data from the National Cardiovascular Data Registry to examine changes in the proportion of initial primary prevention implantable cardioverter-defibrillators placed that did not meet the CMS National Coverage Determination following the announcement of the US Department of Justice investigation at hospitals that did and did not reach settlements.

Research Letter

Maternal Type 1 Diabetes and Risk of Autism in Offspring

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JAMA. 2018;320(1):89-91. doi:10.1001/jama.2018.7614

This cohort study uses electronic health record data to examine associations between maternal diabetes (preexisting type 1, type 2, and gestational) and autism spectrum disorder in children.


Resolving the Productivity Paradox of Health Information Technology: A Time for Optimism

Abstract Full Text
JAMA. 2018;320(1):25-26. doi:10.1001/jama.2018.5605

In this Viewpoint, Robert Wachter and Michael Howell from Google discuss the prospects that medicine is finally poised to realize improvements in quality, safety, and productivity from investments in health information technology and digitization, and from growing competencies in systems thinking and population health

Big Data and Predictive Analytics: Recalibrating Expectations

Abstract Full Text
JAMA. 2018;320(1):27-28. doi:10.1001/jama.2018.5602

This Viewpoint describes 4 major barriers to useful risk prediction that may not be easily overcome by new methods in machine learning and, in some instances, may be more difficult to overcome in the era of big data.

Supporting the Next Generation of Biomedical Researchers

Abstract Full Text
JAMA. 2018;320(1):29-30. doi:10.1001/jama.2018.7902

This Viewpoint summarizes a 2018 National Academies of Sciences, Engineering, and Medicine (NASEM) report that details challenges to support of biomedical scientists in the United States and proposes solutions, including public-private partnerships and a dedicated line of Congressional funding to support next-generation researchers and innovation.

Preparing Physician-Scientists for an Evolving Research Ecosystem

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JAMA. 2018;320(1):31-32. doi:10.1001/jama.2018.4478

In this Viewpoint, Insel and colleagues discuss the roles that private sector companies and foundations might play and the advantages of public-private partnerships in nurturing new and early-career physician-investigators given an always-challenging funding environment and ever-increasing hurdles young physicians must overcome to establish a research career.

A Piece of My Mind

A 30-Mile-per-Hour Headwind

Abstract Full Text
JAMA. 2018;320(1):33-34. doi:10.1001/jama.2018.8191

In this narrative medicine essay, a pediatrician returns to the hospital after riding his bicycle home against a strong headwind to evaluate a neonate with a congenital heart defect and later reflects on whether medical payment for service motivates health care clinicians.


Replacing the Pap Test With Screening Based on Human Papillomavirus Assays

Abstract Full Text
JAMA. 2018;320(1):35-37. doi:10.1001/jama.2018.7911

Revisiting NPH Insulin for Type 2 Diabetes: Is a Step Back the Path Forward?

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JAMA. 2018;320(1):38-39. doi:10.1001/jama.2018.8033

US Department of Justice Investigations of Implantable Cardioverter-Defibrillators and Quality Improvement in Health Care

Abstract Full Text
JAMA. 2018;320(1):40-42. doi:10.1001/jama.2018.8514

Management Considerations in Infective Endocarditis: A Review

Abstract Full Text
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JAMA. 2018;320(1):72-83. doi:10.1001/jama.2018.7596

This narrative review article considers the increasing numbers of patients who contract the infection from cardiac surgical implants, increased intravenous drug use, and poor dental hygiene and discusses ways to treat it prophylactically, surgically, and medically.

JAMA Guide to Statistics and Methods

Odds Ratios—Current Best Practice and Use

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JAMA. 2018;320(1):84-85. doi:10.1001/jama.2018.6971

This JAMA Guide to Statistics and Methods explains the correct usage of odds ratios in the clinical literature to report the strength of the association between binary outcomes.

JAMA Clinical Guidelines Synopsis

Management of Patients With Acute Lower Gastrointestinal Tract Bleeding

Abstract Full Text
JAMA. 2018;320(1):86-87. doi:10.1001/jama.2018.5684

This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterology’s 2016 guideline on management of patients with acute lower GI tract bleeding.

Medical News & Perspectives

Adam Gazzaley, MD, PhD: Developing Prescribable Video Games

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JAMA. 2018;320(1):16-18. doi:10.1001/jama.2018.4985

This Medical News article discusses a video game-based therapy for pediatric attention-deficit/hyperactivity disorder.

Why Merkel Cell Cancer Is Garnering More Attention

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JAMA. 2018;320(1):18-20. doi:10.1001/jama.2018.7042

This Medical News story discusses the growing incidence of basal cell carcinoma and promising treatments for the disease.

News From the Food and Drug Administration

New Relief for Ulcerative Colitis

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JAMA. 2018;320(1):23. doi:10.1001/jama.2018.8554

First Artificial Iris Ok’d

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JAMA. 2018;320(1):23. doi:10.1001/jama.2018.8563

Diagnosing Fractures With AI

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JAMA. 2018;320(1):23. doi:10.1001/jama.2018.8565
The JAMA Forum

Housing as a Step to Better Health

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JAMA. 2018;320(1):21-22. doi:10.1001/jama.2018.7736
Bench to Bedside

New Genetic Links to Depression May Pave the Way for Novel Treatment Strategies

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JAMA. 2018;320(1):20-21. doi:10.1001/jama.2017.12862
The Arts and Medicine

Musical Chairs: Using Wheelchair Ballroom Dance in Disability Education

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JAMA. 2018;320(1):14-15. doi:10.1001/jama.2018.8081

This Arts and Medicine essay describes the use of wheelchair ballroom dance workshops to partner standing abled and seated disabled dancers as a means to equalize the 2 and challenge prevalent attitudes about disability.

Poetry and Medicine

The Hypnotist

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JAMA. 2018;320(1):97. doi:10.1001/jama.2018.1457
JAMA Revisited

The Sin of Treating Symptoms

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JAMA. 2018;320(1):98. doi:10.1001/jama.2017.12446
JAMA Patient Page


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JAMA. 2018;320(1):102. doi:10.1001/jama.2018.7524

This JAMA Patient Page describes the causes, symptoms, diagnosis, and treatment of infective endocarditis.

Comment & Response

Professional Football Participation and Mortality

Abstract Full Text
JAMA. 2018;320(1):91. doi:10.1001/jama.2018.6701

Professional Football Participation and Mortality

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JAMA. 2018;320(1):91-92. doi:10.1001/jama.2018.6705

Professional Football Participation and Mortality—Reply

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JAMA. 2018;320(1):92-93. doi:10.1001/jama.2018.6717

Conflicts of Interest in Nutrition Research

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JAMA. 2018;320(1):93. doi:10.1001/jama.2018.5658

Conflicts of Interest in Nutrition Research

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JAMA. 2018;320(1):93-94. doi:10.1001/jama.2018.5662

Conflict of Interest in Nutrition Research—Reply

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JAMA. 2018;320(1):94-95. doi:10.1001/jama.2018.5678

Moral Dilemmas for Physicians Treating Terminal Patients

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JAMA. 2018;320(1):95. doi:10.1001/jama.2018.6586

Moral Dilemmas for Physicians Treating Terminal Patients—Reply

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JAMA. 2018;320(1):95-96. doi:10.1001/jama.2018.6590

Incorrect Name and Degrees Listed for an Author

Abstract Full Text
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JAMA. 2018;320(1):96. doi:10.1001/jama.2018.8334
JAMA Masthead


Abstract Full Text
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JAMA. 2018;320(1):7-8. doi:10.1001/jama.2017.12439