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January 2019 - July 1883

Decade

Year

Issue

September 25, 2018, Vol 320, No. 12, Pages 1213-1294

In This Issue of JAMA

Highlights

Abstract Full Text
free access has audio
JAMA. 2018;320(12):1213-1215. doi:10.1001/jama.2017.12559
Viewpoint

Genetics, Biochemistry, and “Simple” Organisms Converge to Unlock Secrets in Histone Biology: The 2018 Albert Lasker Basic Medical Research Award

Abstract Full Text
JAMA. 2018;320(12):1233-1234. doi:10.1001/jama.2018.12437

In this Viewpoint, 2018 Albert Lasker Basic Medical Research Award winners Michael Grunstein and C. David Allis discuss the discovery and influence of histones on human genetic expression.

The Discovery and Development of Propofol Anesthesia: The 2018 Lasker-DeBakey Clinical Medical Research Award

Abstract Full Text
JAMA. 2018;320(12):1235-1236. doi:10.1001/jama.2018.12756

In this Viewpoint, 2018 Lasker-DeBakey Clinical Medical Research Award winner John B. Glen discusses the discovery and development of propofol, one of the most widely used anesthetics for patient care.

Reducing Maternal Mortality in the United States

Abstract Full Text
JAMA. 2018;320(12):1237-1238. doi:10.1001/jama.2018.11652

This Viewpoint suggests strategies for reducing maternal mortality in the United States, including creation of a national maternal mortality surveillance system, use of maternal safety bundles within health systems, and improving access to quality health care for all women.

The Acute Stroke Care Revolution: Enhancing Access to Therapeutic Advances

Abstract Full Text
JAMA. 2018;320(12):1239-1240. doi:10.1001/jama.2018.11122

This Viewpoint reviews evidence of the benefits of thrombectomy for patients with ischemic stroke due to large vessel occlusion, and details the systems of care that need to be developed to ensure that all patients who might benefit from the procedure can be rapidly identified, transported, imaged, and treated under the care of qualified specialists.

A Piece of My Mind

Letting Her Be in Charge

Abstract Full Text
JAMA. 2018;320(12):1241-1242. doi:10.1001/jama.2018.13098

In this narrative medicine essay, a physician and her family struggle with their mother’s intention to continue chemotherapy when treatment will cause more harm than good.

Editorial

Treatment Algorithms for Staphylococcal Bacteremia: Improving Clinical Care and Enhancing Antimicrobial Stewardship

Abstract Full Text
JAMA. 2018;320(12):1243-1244. doi:10.1001/jama.2018.13315

Antibiotic Treatment for Uncomplicated Appendicitis Really Works: Results From 5 Years of Observation in the APPAC Trial

Abstract Full Text
JAMA. 2018;320(12):1245-1246. doi:10.1001/jama.2018.13368

Making Sense of the Genome Remains a Work in Progress

Abstract Full Text
JAMA. 2018;320(12):1247-1248. doi:10.1001/jama.2018.11784
Original Investigation

Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial

Abstract Full Text
JAMA. 2018;320(12):1249-1258. doi:10.1001/jama.2018.13155

This noninferiority trial compares the effects on clinical success and adverse events of an algorithm that defines diagnostic evaluation, antibiotic selection, and duration of therapy for staphylococcal bacteremia vs standard clinical care.

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

Abstract Full Text
has active quiz has multimedia has audio
JAMA. 2018;320(12):1259-1265. doi:10.1001/jama.2018.13201

During a 5-year follow-up of patients initially treated with antibiotics for uncomplicated acute appendicitis, this observational study assesses the rate of late recurrence.

Prevalence of Variant Reclassification Following Hereditary Cancer Genetic Testing

Abstract Full Text
has active quiz
JAMA. 2018;320(12):1266-1274. doi:10.1001/jama.2018.13152

This genetic epidemiology study uses data from a commercial genetic test laboratory to characterize the proportion of genes of uncertain clinical significance that were reclassified into more determinate benign or pathogenic categories of risk based on emerging evidence among patients undergoing hereditary cancer risk assessment between 2006 and 2016.

JAMA Insights

Clinical Update

Fractional Flow Reserve Measurement for the Physiological Assessment of Coronary Artery Stenosis Severity

Abstract Full Text
JAMA. 2018;320(12):1275-1276. doi:10.1001/jama.2018.10683

This Clinical Update explains the uses and interpretation of fractional flow reserve (FFR) measures that quantify the pressure gradient proximal and distal to intracoronary lesions and determine the clinical significance of angiographically detected coronary artery stenoses.

Clinical Update

Breast Reconstruction Following Breast Cancer Treatment—2018

Abstract Full Text
JAMA. 2018;320(12):1277-1278. doi:10.1001/jama.2018.12190

This Clinical Update summarizes contemporary prosthetic and autologous breast reconstruction options for women undergoing lumpectomy or mastectomy for breast cancer, and reviews data on indications, safety, and timing for the procedures.

JAMA Diagnostic Test Interpretation

Esophageal High-Resolution Manometry in Gastroesophageal Reflux Disease

Abstract Full Text
has active quiz
JAMA. 2018;320(12):1279-1280. doi:10.1001/jama.2018.8694

A 22-year-old man with a 10-year history of gastroesophageal reflux disease (GERD)–like symptoms and taking 20 mg/d of omeprazole had a normal esophagogastroduodenoscopy (EGD) and was diagnosed with achalasia following a high-resolution manometry (HRM) study. What would you do next?

Research Letter

Temporal Trends and Characteristics of Reportable Health Data Breaches, 2010-2017

Abstract Full Text
JAMA. 2018;320(12):1282-1284. doi:10.1001/jama.2018.9222

This study uses public data to examine the nature and extent of health data confidentiality breaches from 2010 through 2017

Medical News & Perspectives

The Path to the First FDA-Approved Cannabis-Derived Treatment and What Comes Next

Abstract Full Text
JAMA. 2018;320(12):1227-1229. doi:10.1001/jama.2018.11914

This Medical News story discusses the history of Epidiolex and whether its approval to treat 2 rare epilepsy syndromes will foster the development of more cannabis-derived therapies.

News From the Centers for Disease Control and Prevention

Opioid Use Disorder During Pregnancy

Abstract Full Text
JAMA. 2018;320(12):1232. doi:10.1001/jama.2018.13546

Disability and Access to Care

Abstract Full Text
JAMA. 2018;320(12):1232. doi:10.1001/jama.2018.13336
Clinical Trials Update

Mosaic HIV Vaccine Shows Promise

Abstract Full Text
JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13249

Antipsychotics May Affect Metabolism

Abstract Full Text
JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13871

Study Lays Foundation for TB Vaccine

Abstract Full Text
JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13872

Direct-mail FIT Improves Cancer Screening Rates

Abstract Full Text
JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13874

Informing Physicians of Fatal Overdose Curbs Opioid Prescribing

Abstract Full Text
JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13875
Health Agencies Update

Obesity and Influenza A Shedding

Abstract Full Text
JAMA. 2018;320(12):1230. doi:10.1001/jama.2018.13078

Diversifying the NIH-Funded Workforce

Abstract Full Text
JAMA. 2018;320(12):1230. doi:10.1001/jama.2018.13868

Indian Health Service Launches Opioids Website

Abstract Full Text
JAMA. 2018;320(12):1230. doi:10.1001/jama.2018.13869
Comment & Response

Antibiotic Treatment for Uncomplicated Urinary Tract Infections

Abstract Full Text
JAMA. 2018;320(12):1284. doi:10.1001/jama.2018.10011

Antibiotic Treatment for Uncomplicated Urinary Tract Infections—Reply

Abstract Full Text
JAMA. 2018;320(12):1284-1285. doi:10.1001/jama.2018.10018

Use of a Wearable Activity Monitor in a Home-Based Exercise Intervention for Peripheral Artery Disease

Abstract Full Text
JAMA. 2018;320(12):1285-1286. doi:10.1001/jama.2018.10771

Use of a Wearable Activity Monitor in a Home-Based Exercise Intervention for Peripheral Artery Disease—Reply

Abstract Full Text
JAMA. 2018;320(12):1286. doi:10.1001/jama.2018.10775

Improving Health Care Value by Considering Cost-effectiveness

Abstract Full Text
JAMA. 2018;320(12):1287. doi:10.1001/jama.2018.10620

Improving Health Care Value by Considering Cost-effectiveness—Reply

Abstract Full Text
JAMA. 2018;320(12):1287-1288. doi:10.1001/jama.2018.10624
Correction

Adjusted Data for 2013 Birth Cohort in a Table

Abstract Full Text
free access
JAMA. 2018;320(12):1288. doi:10.1001/jama.2018.13235

Incorrect Values in Results Subsections

Abstract Full Text
free access
JAMA. 2018;320(12):1288. doi:10.1001/jama.2018.13590

Unit of Measure Error

Abstract Full Text
free access
JAMA. 2018;320(12):1288. doi:10.1001/jama.2018.13694

Omission of Conflicts of Interest

Abstract Full Text
free access
JAMA. 2018;320(12):1288. doi:10.1001/jama.2018.13704
The Arts and Medicine

Cystic Fibrosis in Art

Abstract Full Text
JAMA. 2018;320(12):1224-1226. doi:10.1001/jama.2018.12769

This JAMA Arts & Medicine article features work in which artists living with cystic fibrosis express their experiences.

Poetry and Medicine

Runner Heal Thyself

Abstract Full Text
JAMA. 2018;320(12):1289. doi:10.1001/jama.2018.6658
JAMA Revisited

The Daily Press and the “Futilities of Contemporary Science”

Abstract Full Text
JAMA. 2018;320(12):1290. doi:10.1001/jama.2017.12589
JAMA Patient Page

Gallbladder Cancer

Abstract Full Text
free access
JAMA. 2018;320(12):1294. doi:10.1001/jama.2018.11815

This JAMA Patient Page describes the symptoms, diagnosis, and treatment of gallbladder cancer.

JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2018;320(12):1217-1218. doi:10.1001/jama.2017.12560
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