In this Viewpoint, 2018 Albert Lasker Basic Medical Research Award winners Michael Grunstein and C. David Allis discuss the discovery and influence of histones on human genetic expression.
In this Viewpoint, 2018 Lasker-DeBakey Clinical Medical Research Award winner John B. Glen discusses the discovery and development of propofol, one of the most widely used anesthetics for patient care.
This Viewpoint suggests strategies for reducing maternal mortality in the United States, including creation of a national maternal mortality surveillance system, use of maternal safety bundles within health systems, and improving access to quality health care for all women.
This Viewpoint reviews evidence of the benefits of thrombectomy for patients with ischemic stroke due to large vessel occlusion, and details the systems of care that need to be developed to ensure that all patients who might benefit from the procedure can be rapidly identified, transported, imaged, and treated under the care of qualified specialists.
In this narrative medicine essay, a physician and her family struggle with their mother’s intention to continue chemotherapy when treatment will cause more harm than good.
This noninferiority trial compares the effects on clinical success and adverse events of an algorithm that defines diagnostic evaluation, antibiotic selection, and duration of therapy for staphylococcal bacteremia vs standard clinical care.
During a 5-year follow-up of patients initially treated with antibiotics for uncomplicated acute appendicitis, this observational study assesses the rate of late recurrence.
This genetic epidemiology study uses data from a commercial genetic test laboratory to characterize the proportion of genes of uncertain clinical significance that were reclassified into more determinate benign or pathogenic categories of risk based on emerging evidence among patients undergoing hereditary cancer risk assessment between 2006 and 2016.
This Clinical Update explains the uses and interpretation of fractional flow reserve (FFR) measures that quantify the pressure gradient proximal and distal to intracoronary lesions and determine the clinical significance of angiographically detected coronary artery stenoses.
This Clinical Update summarizes contemporary prosthetic and autologous breast reconstruction options for women undergoing lumpectomy or mastectomy for breast cancer, and reviews data on indications, safety, and timing for the procedures.
A 22-year-old man with a 10-year history of gastroesophageal reflux disease (GERD)–like symptoms and taking 20 mg/d of omeprazole had a normal esophagogastroduodenoscopy (EGD) and was diagnosed with achalasia following a high-resolution manometry (HRM) study. What would you do next?
This study uses public data to examine the nature and extent of health data confidentiality breaches from 2010 through 2017
This Medical News story discusses the history of Epidiolex and whether its approval to treat 2 rare epilepsy syndromes will foster the development of more cannabis-derived therapies.
This JAMA Arts & Medicine article features work in which artists living with cystic fibrosis express their experiences.
This JAMA Patient Page describes the symptoms, diagnosis, and treatment of gallbladder cancer.
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