In this Viewpoint, Anthony Fauci summarizes the National Institute of Allergy and Infectious Diseases’ (NIAID’s) 2018 Strategic Plan for Tuberculosis (TB), which comprises investments in development of point-of-care diagnostics, vaccines, shorter-duration therapeutics, and infrastructure for systems biology and “omics” approaches to the infection.
In this Viewpoint, Don Berwick and colleagues summarize a 2018 National Academies of Sciences, Engineering, and Medicine (NASEM) report on global health care quality emphasizing that universal access will yield improvements in population health only when paired with quality reforms characterized by systems design, transparency, collaboration, anticipatory care, evidence-based decisions, and continuous feedback and learning.
This Viewpoint describes the processes by which aging of cells contributes to age-related decline, chronic disease, and multimorbidity, and describes current animal research and clinical trials investigating the effects of senolytic drugs and vaccines that target senescent cell antiapoptotic pathways and remove senescent cells.
This Viewpoint discusses targeting fundamental biological aging processes through nutritional, genetic, and pharmacologic interventions to delay or prevent the onset or progression of multiple chronic diseases and debilities typically observed in older humans to enhance and extend both health and longevity.
This viewpoint discusses increased life expectancy and the initiatives to address the risks and unintended consequences of living longer.
In this narrative medicine essay, a geriatric and palliative care physician shares his understanding that the patience, flexibility, humility, and presence required to grow a garden are entirely appropriate for end-of-life patient care.
This noninferiority trial compares the effects of arthroscopic partial meniscectomy vs physical therapy on patient-reported knee function in patients with meniscal tears.
This cohort study of black and white adults investigates demographic, physical, and lifestyle factors that might account for differences in incidence of hypertension in black vs white US adults.
This meta-analysis of randomized trials assesses the association of thyroid hormone therapy with quality of life (QOL) and thyroid-related symptoms in nonpregnant adults with subclinical hypothyroidism.
This narrative review summarizes current evidence regarding the pathophysiology, diagnosis, and treatment of rheumatoid arthritis.
An asymptomatic 66-year-old man had a 3.1-cm left adrenal mass detected on CT scan with normal vital signs, BMI of 37, normal physical examination, and an elevated cortisol level after an overnight 1-mg dexamethasone suppression test. What would you do next?
This Medical Letter review summarizes clinical studies, adverse effects, dosage, and administration for a 6% otic suspension formulation of the fluoroquinolone antibiotic ciprofloxacin (Otiprio), approved by the US Food and Drug Administration in 2018 for single-dose treatment of acute otitis externa.
This study uses e-cigarette retail sales data to estimate estimate e-cigarette sales and market share of e-cigarette sales by manufacturer in the United States during 2013-2017.
This Research Letter evaluates the amount of sugars found in cigarillos by brand.
Beef and poultry grown from animal cells rather than sourced from whole animals could be the future of meat production, a cardiologist-turned-biotech entrepreneur says in this Medical News article.
This JAMA Patient Page describes tinea versicolor and its symptoms, diagnosis, and treatment.
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