This randomized clinical trial compares the effects of a multimodal program involving education and role-play in simulated patient care sequences vs no intervention on work-related stress and work-related outcomes among nurses working at adult intensive care units (ICUs) in France.
This randomized clinical trial determines the optimal therapeutic dose, effect on kidney function, and adverse effects of human recombinant alkaline phosphatase in patients who are critically ill with sepsis-associated acute kidney injury.
This randomized clinical trial compares the effect of adding the somatostatin analogue lanreotide to standard care vs standard care alone on change in estimated glomerular filtration rate (eGFR) in patients with autosomal dominant polycystic kidney disease (PCKD).
This before-after study investigates changes in concussion among Ivy League football players after implementation of a 2016 rule change intended to land more kickoffs in the end zone and reduce player injury.
This study uses 2015-2016 National Health and Nutrition Examination Survey data to assess prevalence of daily sitting time and weekly leisure-time physical activity among US adults.
This Special Communication from the US Department of Health and Human Services summarizes key guidelines and recommendations in the Physical Activity Guidelines for Americans, 2nd edition.
This Viewpoint from the US Assistant Secretary for Health discusses the Physical Activity Guidelines for Americans, 2nd edition, and proposes ways in which the medical care system, new technologies, workplace initiatives, and enhanced youth participation in sports can promote physical activity.
This Viewpoint discusses the changing role of physicians in an era when patients are self-educated about their conditions and can order tests online, evolving from physician paternalism to a role of patient consultant, procedural expert, and gatekeeper to second-line follow-up services.
This Viewpoint discusses ways in which health apps can be improved and regulated by the US Food and Drug Administration to improve health in patients and confidence in the apps by physicians.
This Viewpoint discusses a “Netflix” subscription model of drug payment being investigated by Louisiana for hepatitis C (HCV) drugs, in which a statewide coalition of payers would pay subscription fees over a fixed number of years for HCV drugs to treat all state residents and for efforts by the manufacturers to enhance treatment rates through patient outreach.
In this narrative medicine essay, 2 female physicians recount uncomfortable moments during their training when patients made inappropriate comments, and they challenge teaching physicians to address such comments in real time to educate patients and defend an equitable learning environment for trainees.
A 25-year-old Bangladeshi immigrant presented with a hyperpigmented, hypoesthetic macule on her palm and an enlarged ulnar nerve. A previous biopsy of the palm lesion had revealed perineural granulomas with inflammatory cells that stained negative for acid-fast bacilli and fungi. What would you do next?
A 68-year-old man has an undetectable hepatitis C (HCV) viral load, normal liver function tests, and an elevated vibration-controlled transient elastography (VCTE) measure after 12 weeks of antiviral treatment for HCV with stage 2 fibrosis by biopsy. How do you interpret the results?
This Medical News article discusses the discovery of RNAi and developments in its use as a therapeutic tool to treat genetic diseases.
This JAMA Patient Page describes the endoscopic retrograde cholangiopancreatography procedure and its purposes.
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