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March 2023 - July 1883




November 20, 2018, Vol 320, No. 19, Pages 1955-2050

In This Issue of JAMA


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JAMA. 2018;320(19):1955-1957. doi:10.1001/jama.2017.12636
Original Investigation

Caring for the Critically Ill Patient

Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in Intensive Care Units: A Randomized Clinical Trial

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JAMA. 2018;320(19):1988-1997. doi:10.1001/jama.2018.14284

This randomized clinical trial compares the effects of a multimodal program involving education and role-play in simulated patient care sequences vs no intervention on work-related stress and work-related outcomes among nurses working at adult intensive care units (ICUs) in France.

Caring for the Critically Ill Patient

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial

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JAMA. 2018;320(19):1998-2009. doi:10.1001/jama.2018.14283

This randomized clinical trial determines the optimal therapeutic dose, effect on kidney function, and adverse effects of human recombinant alkaline phosphatase in patients who are critically ill with sepsis-associated acute kidney injury.

Effect of Lanreotide on Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease: The DIPAK 1 Randomized Clinical Trial

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JAMA. 2018;320(19):2010-2019. doi:10.1001/jama.2018.15870

This randomized clinical trial compares the effect of adding the somatostatin analogue lanreotide to standard care vs standard care alone on change in estimated glomerular filtration rate (eGFR) in patients with autosomal dominant polycystic kidney disease (PCKD).

Research Letter

Association Between the Experimental Kickoff Rule and Concussion Rates in Ivy League Football

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JAMA. 2018;320(19):2035-2036. doi:10.1001/jama.2018.14165

This before-after study investigates changes in concussion among Ivy League football players after implementation of a 2016 rule change intended to land more kickoffs in the end zone and reduce player injury.

Joint Prevalence of Sitting Time and Leisure-Time Physical Activity Among US Adults, 2015-2016

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JAMA. 2018;320(19):2036-2038. doi:10.1001/jama.2018.17797

This study uses 2015-2016 National Health and Nutrition Examination Survey data to assess prevalence of daily sitting time and weekly leisure-time physical activity among US adults.

Special Communication

The Physical Activity Guidelines for Americans

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JAMA. 2018;320(19):2020-2028. doi:10.1001/jama.2018.14854

This Special Communication from the US Department of Health and Human Services summarizes key guidelines and recommendations in the Physical Activity Guidelines for Americans, 2nd edition.


Physical Activity Guidelines for Health and Prosperity in the United States

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JAMA. 2018;320(19):1971-1972. doi:10.1001/jama.2018.16998

This Viewpoint from the US Assistant Secretary for Health discusses the Physical Activity Guidelines for Americans, 2nd edition, and proposes ways in which the medical care system, new technologies, workplace initiatives, and enhanced youth participation in sports can promote physical activity.

The New Age of Patient Autonomy: Implications for the Patient-Physician Relationship

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JAMA. 2018;320(19):1973-1974. doi:10.1001/jama.2018.14382

This Viewpoint discusses the changing role of physicians in an era when patients are self-educated about their conditions and can order tests online, evolving from physician paternalism to a role of patient consultant, procedural expert, and gatekeeper to second-line follow-up services.

Health Apps and Health Policy: What Is Needed?

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JAMA. 2018;320(19):1975-1976. doi:10.1001/jama.2018.14378

This Viewpoint discusses ways in which health apps can be improved and regulated by the US Food and Drug Administration to improve health in patients and confidence in the apps by physicians.

Alternative State-Level Financing for Hepatitis C Treatment—The “Netflix Model”

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JAMA. 2018;320(19):1977-1978. doi:10.1001/jama.2018.15782

This Viewpoint discusses a “Netflix” subscription model of drug payment being investigated by Louisiana for hepatitis C (HCV) drugs, in which a statewide coalition of payers would pay subscription fees over a fixed number of years for HCV drugs to treat all state residents and for efforts by the manufacturers to enhance treatment rates through patient outreach.

A Piece of My Mind

Solving the Silence

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JAMA. 2018;320(19):1979-1980. doi:10.1001/jama.2018.15686

In this narrative medicine essay, 2 female physicians recount uncomfortable moments during their training when patients made inappropriate comments, and they challenge teaching physicians to address such comments in real time to educate patients and defend an equitable learning environment for trainees.


Reducing the Stress on Clinicians Working in the ICU

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JAMA. 2018;320(19):1981-1982. doi:10.1001/jama.2018.14285

New Physical Activity Guidelines: A Call to Activity for Clinicians and Patients

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JAMA. 2018;320(19):1983-1984. doi:10.1001/jama.2018.16070

Scientific Misconduct and Medical Journals

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JAMA. 2018;320(19):1985-1987. doi:10.1001/jama.2018.14350
JAMA Clinical Challenge

Hyperpigmented Macule on the Palm and Diminished Sensation

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JAMA. 2018;320(19):2029-2030. doi:10.1001/jama.2018.14701

A 25-year-old Bangladeshi immigrant presented with a hyperpigmented, hypoesthetic macule on her palm and an enlarged ulnar nerve. A previous biopsy of the palm lesion had revealed perineural granulomas with inflammatory cells that stained negative for acid-fast bacilli and fungi. What would you do next?

JAMA Diagnostic Test Interpretation

Vibration-Controlled Transient Elastography for Diagnosing Cirrhosis and Staging Hepatic Fibrosis

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JAMA. 2018;320(19):2031-2032. doi:10.1001/jama.2018.13073

A 68-year-old man has an undetectable hepatitis C (HCV) viral load, normal liver function tests, and an elevated vibration-controlled transient elastography (VCTE) measure after 12 weeks of antiviral treatment for HCV with stage 2 fibrosis by biopsy. How do you interpret the results?

Medical News & Perspectives

RNAi Rollercoaster Begins to Reap Therapies

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JAMA. 2018;320(19):1963-1965. doi:10.1001/jama.2018.14898

This Medical News article discusses the discovery of RNAi and developments in its use as a therapeutic tool to treat genetic diseases.

News From the Food and Drug Administration

FDA Joins New Effort to Strengthen Medical Device Cybersecurity

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JAMA. 2018;320(19):1970. doi:10.1001/jama.2018.17834

Will Naloxone Become Available OTC?

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JAMA. 2018;320(19):1970. doi:10.1001/jama.2018.17836

Blood Group Genotyping Test Goes Beyond A, B, and O

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JAMA. 2018;320(19):1970. doi:10.1001/jama.2018.17838
The JAMA Forum

Progress in Primary Care—From Alma-Ata to Astana

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JAMA. 2018;320(19):1965-1966. doi:10.1001/jama.2018.16957
Bench to Bedside

For Difficult-to-Model Brain Diseases, Brain Organoids Come to the Rescue

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JAMA. 2018;320(19):1966-1968. doi:10.1001/jama.2018.15972
Global Health

Mapping Yellow Fever Virus in Brazil

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JAMA. 2018;320(19):1969. doi:10.1001/jama.2018.17155

Global Hunger on the Rise as Climate Extremes Increase

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JAMA. 2018;320(19):1969. doi:10.1001/jama.2018.17909

Guidelines for Ending Childhood and Adolescent Tuberculosis

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JAMA. 2018;320(19):1969. doi:10.1001/jama.2018.17910
Poetry and Medicine

I Pray

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JAMA. 2018;320(19):2044. doi:10.1001/jama.2018.7869
JAMA Revisited

Current Comment

Abstract Full Text
JAMA. 2018;320(19):2045. doi:10.1001/jama.2017.12666
JAMA Patient Page

Endoscopic Retrograde Cholangiopancreatography

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JAMA. 2018;320(19):2050. doi:10.1001/jama.2018.14481

This JAMA Patient Page describes the endoscopic retrograde cholangiopancreatography procedure and its purposes.

Comment & Response

Validity of the qSOFA Score in Low- and Middle-Income Countries

Abstract Full Text
JAMA. 2018;320(19):2038-2039. doi:10.1001/jama.2018.14473

Validity of the qSOFA Score in Low- and Middle-Income Countries—Reply

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JAMA. 2018;320(19):2039-2040. doi:10.1001/jama.2018.14477

Maryland’s Hospital Global Budget Program

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JAMA. 2018;320(19):2040. doi:10.1001/jama.2018.14370

Maryland’s Hospital Global Budget Program—Reply

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JAMA. 2018;320(19):2040-2041. doi:10.1001/jama.2018.14374

Odds Ratios vs Risk Ratios

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JAMA. 2018;320(19):2041. doi:10.1001/jama.2018.14417

Odds Ratios vs Risk Ratios—Reply

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JAMA. 2018;320(19):2041-2042. doi:10.1001/jama.2018.14421

Breakthrough Therapy Designation for New Drugs

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JAMA. 2018;320(19):2042. doi:10.1001/jama.2018.15938

Breakthrough Therapy Designation for New Drugs—Reply

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JAMA. 2018;320(19):2042-2043. doi:10.1001/jama.2018.15942
JAMA Masthead


Abstract Full Text
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JAMA. 2018;320(19):1959-1960. doi:10.1001/jama.2017.12637