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October 2021 - July 1883

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November 27, 2018, Vol 320, No. 20, Pages 2053-2160

In This Issue of JAMA

Highlights

Abstract Full Text
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JAMA. 2018;320(20):2053-2055. doi:10.1001/jama.2017.12647
Original Investigation

Caring for the Critically Ill Patient

Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial

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JAMA. 2018;320(20):2087-2098. doi:10.1001/jama.2018.13765

This cluster randomized trial compares associations between commonly used decontamination strategies (chlorhexidine 2% mouthwash, selective oropharyngeal decontamination, and selective digestive tract decontamination) and occurrence of intensive care unit (ICU)–acquired bloodstream infections with multidrug-resistant gram-negative bacteria in ICUs with moderate to high levels of antibiotic resistance.

Caring for the Critically Ill Patient

Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial

Abstract Full Text
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JAMA. 2018;320(20):2099-2107. doi:10.1001/jama.2018.14282

This randomized clinical trial compares the effects of high-flow nasal vs standard oxygen therapy on 28-day mortality among immunocompromised patients with acute hypoxemic respiratory failure.

Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2018;320(20):2108-2121. doi:10.1001/jama.2018.16773

This randomized clinical trial compares the ability of lanadelumab—a human monoclonal antibody that selectively inhibits active plasma kallikrein—vs placebo to prevent angioedema among patients with types I and II hereditary angioedema.

Research Letter

Trends in Telemedicine Use in a Large Commercially Insured Population, 2005-2017

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JAMA. 2018;320(20):2147-2149. doi:10.1001/jama.2018.12354

This study uses insurance claims database to describe trends in telemedicine use and its associations with physician supply and with state laws madating coverage in a large commercially insured population between 2005 and 2017.

Trends in First Gabapentin and Pregabalin Prescriptions in Primary Care in the United Kingdom, 1993-2017

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JAMA. 2018;320(20):2149-2151. doi:10.1001/jama.2018.12358

This study examined the rates of patients in the United Kingdom treated with gabapentin and pregabalin for the first time, and the rates of these patients with an off-label indication or a coprescription of opioids or benzodiazepines.

US Preventive Services Task Force

Recommendation Statement

Interventions to Prevent Child Maltreatment: US Preventive Services Task Force Recommendation Statement

Abstract Full Text
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JAMA. 2018;320(20):2122-2128. doi:10.1001/jama.2018.17772

This 2018 Recommendation Statement from the US Preventive Services Task Force concludes that the current evidence is insufficient to assess the balance of benefits and harms of primary care interventions to prevent child maltreatment (I statement).

Evidence Report

Primary Care Interventions to Prevent Child Maltreatment: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

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JAMA. 2018;320(20):2129-2140. doi:10.1001/jama.2018.17647

This systematic review to support the 2018 US Preventive Services Task Force Recommendation Statement on primary care interventions to prevent child maltreatment summarizes published evidence on the benefits and harms of interventions to prevent maltreatment among children with no signs or symptoms of current or past maltreatment.

Viewpoint

How to Make US Health Care More Equitable and Less Costly: Begin by Replacing Employment-Based Insurance

Abstract Full Text
JAMA. 2018;320(20):2071-2072. doi:10.1001/jama.2018.16475

This Viewpoint argues for reform of the US health care system, starting with the elimination of employment-based insurance.

Current and Future Landscape of Nutritional Epidemiologic Research

Abstract Full Text
JAMA. 2018;320(20):2073-2074. doi:10.1001/jama.2018.16166

In this Viewpoint, Hu and Willett survey the accomplishments and future directions of nutritional epidemiology research, arguing for a multidisciplinary approach across the lifecycle using new digital technologies as the best means to address existing uncertainties about optimal diet and nutrition.

The “Public Charge” Proposal and Public Health: Implications for Patients and Clinicians

Abstract Full Text
JAMA. 2018;320(20):2075-2076. doi:10.1001/jama.2018.16391

This Viewpoint discusses the proposed implementation of “public charge” to immigration policy that would make receipt of public assistance grounds for denying immigrants lawful permanent residence in the United States.

Increasing the Participation of Pregnant Women in Clinical Trials

Abstract Full Text
JAMA. 2018;320(20):2077-2078. doi:10.1001/jama.2018.17716

This Viewpoint discusses widespread perceptions of vulnerability and risk that discourage enrollment of pregnant women in clinical trials, and calls for actionable guidelines to overcome those perceptions and eliminate barriers to their participation.

A Piece of My Mind

Seeing the Present Through the Past: History, Empathy, and Medical Education

Abstract Full Text
JAMA. 2018;320(20):2079-2080. doi:10.1001/jama.2018.17253

In this narrative medicine essay, an MD-PhD candidate purssuing a graduate degree in the history of medicine uses her study of an early HIV/AIDS archive to reflect on the importance of history in contribution to a proper understanding of contemporary health care and policy and on its vital role in teaching students empathy and emotional intelligence.

Editorial

Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit

Abstract Full Text
JAMA. 2018;320(20):2081-2083. doi:10.1001/jama.2018.13764

High-Flow Nasal Oxygen—The Pendulum Continues to Swing in the Assessment of Critical Care Technology

Abstract Full Text
JAMA. 2018;320(20):2083-2084. doi:10.1001/jama.2018.14287

Preventing Maltreatment of Children

Abstract Full Text
JAMA. 2018;320(20):2085-2086. doi:10.1001/jama.2018.18704
JAMA Clinical Challenge

Multiple Lung Masses in a Young Woman

Abstract Full Text
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JAMA. 2018;320(20):2141-2142. doi:10.1001/jama.2018.14770

A 38-year-old woman with a history of gastric bypass surgery and hysterectomy had acute abdominal pain. Results of routine blood testing were unremarkable; a lung biopsy revealed spindle-cell fascicles with entrapped benign alveolar tissue but no necrosis, atypia, or mitotic activity. What would you do next?

From The Medical Letter on Drugs and Therapeutics

Influenza Vaccine for 2018-2019

Abstract Full Text
JAMA. 2018;320(20):2143-2144. doi:10.1001/jama.2018.17725

This Medical Letter review summarizes information on the timing, composition, effectiveness, and adverse effects of the 2018-2019 influenza vaccine.

Medical News & Perspectives

Have Tent, Will Do Pop-up HIV Screening

Abstract Full Text
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JAMA. 2018;320(20):2063-2065. doi:10.1001/jama.2018.16245

This Medical News article is an interview with the founders of One Tent Health, a nonprofit free HIV screening initiative that serves high-risk neighborhoods in Washington, DC.

The JAMA Forum

Curbing Surprise Medical Bills Can Be a Window Into Cost Control

Abstract Full Text
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JAMA. 2018;320(20):2065-2066. doi:10.1001/jama.2018.17418
News From the Centers for Disease Control and Prevention

Mystery Myelitis in Children

Abstract Full Text
JAMA. 2018;320(20):2069. doi:10.1001/jama.2018.17696

Unvaccinated Children

Abstract Full Text
JAMA. 2018;320(20):2069. doi:10.1001/jama.2018.17829
Clinical Trials Update

Vaccine Prevents Active Tuberculosis

Abstract Full Text
JAMA. 2018;320(20):2068. doi:10.1001/jama.2018.17808

Behavior Therapy for Cognitive Decline

Abstract Full Text
JAMA. 2018;320(20):2068. doi:10.1001/jama.2018.18510

High-Dose Folic Acid Does Not Prevent Preeclampsia

Abstract Full Text
JAMA. 2018;320(20):2068. doi:10.1001/jama.2018.18511

Artificial Pancreas Improves Glycemic Control

Abstract Full Text
JAMA. 2018;320(20):2068. doi:10.1001/jama.2018.18512

Hypertension Drug Fails to Slow Cognitive Decline

Abstract Full Text
JAMA. 2018;320(20):2068. doi:10.1001/jama.2018.18513
Health Agencies Update

Opioid-Related Problems Increasing Among Older Adults

Abstract Full Text
JAMA. 2018;320(20):2067. doi:10.1001/jama.2018.17630

Declining Numbers of Rural US Hospitals

Abstract Full Text
JAMA. 2018;320(20):2067. doi:10.1001/jama.2018.18506

New NIH-DoD Limb Loss Registry

Abstract Full Text
JAMA. 2018;320(20):2067. doi:10.1001/jama.2018.18508
Poetry and Medicine

The Art of Suffering

Abstract Full Text
JAMA. 2018;320(20):2155. doi:10.1001/jama.2018.11600
JAMA Revisited

The Production of Drug Plants in the United States

Abstract Full Text
JAMA. 2018;320(20):2156. doi:10.1001/jama.2017.12677
JAMA Patient Page

Interventions to Prevent Child Maltreatment

Abstract Full Text
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JAMA. 2018;320(20):2160. doi:10.1001/jama.2018.17741

This JAMA Patient Page describes the US Preventive Services Task Force’s recommendations on interventions to prevent child maltreatment.

Comment & Response

Cardiac Outcomes After Treatment for Depression in Patients With Acute Coronary Syndrome

Abstract Full Text
JAMA. 2018;320(20):2151. doi:10.1001/jama.2018.15922

Cardiac Outcomes After Treatment for Depression in Patients With Acute Coronary Syndrome

Abstract Full Text
JAMA. 2018;320(20):2151-2152. doi:10.1001/jama.2018.15930

Cardiac Outcomes After Treatment for Depression in Patients With Acute Coronary Syndrome

Abstract Full Text
JAMA. 2018;320(20):2152. doi:10.1001/jama.2018.15934

Cardiac Outcomes After Treatment for Depression in Patients With Acute Coronary Syndrome—Reply

Abstract Full Text
JAMA. 2018;320(20):2152-2153. doi:10.1001/jama.2018.15950

Baseline Genotype Testing to Assess Drug Resistance Before Beginning HIV Treatment

Abstract Full Text
JAMA. 2018;320(20):2153-2154. doi:10.1001/jama.2018.15926

Baseline Genotype Testing to Assess Drug Resistance Before Beginning HIV Treatment—Reply

Abstract Full Text
JAMA. 2018;320(20):2154. doi:10.1001/jama.2018.15946
Correction

Incorrect Data in Figures

Abstract Full Text
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JAMA. 2018;320(20):2154. doi:10.1001/jama.2018.15103

Unclear Sentence and Incorrect Number in Figure

Abstract Full Text
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JAMA. 2018;320(20):2154. doi:10.1001/jama.2018.18424
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2018;320(20):2057-2058. doi:10.1001/jama.2017.12648
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