[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]

July 2019 - July 1883




December 11, 2018, Vol 320, No. 22, Pages 2283-2387

In This Issue of JAMA


Abstract Full Text
free access has audio
JAMA. 2018;320(22):2283-2285. doi:10.1001/jama.2017.12669
Original Investigation

Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial

Abstract Full Text
free access has active quiz
JAMA. 2018;320(22):2325-2334. doi:10.1001/jama.2018.17749

This randomized, open-label, blinded end point randomized clinical trial examined the effect of oral alfacalcidol, a vitamin D receptor activator, on cardiovascular events in patients with cardiovascular kidney disease receiving hemodialysis.

Effect of a Program Combining Transitional Care and Long-term Self-management Support on Outcomes of Hospitalized Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA. 2018;320(22):2335-2343. doi:10.1001/jama.2018.17933

This randomized clinical trial compares the effects of a program combining transition and long-term self-management support vs transition support alone on 6-month hospitalizations and emergency department visits among patients with chronic obstructive pulmonary disease (COPD).

Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia Evaluated Using Aggregated N-of-1 Trials

Abstract Full Text
free access has audio
JAMA. 2018;320(22):2344-2353. doi:10.1001/jama.2018.18020

This study uses a series of aggregated N-of-1 trials to investigate the effectiveness of mexiletine for treatment of muscle stiffness in adult patients with nondystrophic myotonia and compares results from this series with those from a previously conducted randomized clinical trial.

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

Abstract Full Text
free access
JAMA. 2018;320(22):2354-2364. doi:10.1001/jama.2018.18179

This nested case-control study of patients with early-onset atrial fibrillation (AF) used large-scale, deep-coverage whole-genome sequencing to identify a loss-of-function variant in TTN, the gene encoding the rare nerve protein titin, as a genetic risk factor for early AF.

Research Letter

Childbearing and Family Leave Policies for Resident Physicians at Top Training Institutions

Abstract Full Text
free access
JAMA. 2018;320(22):2372-2374. doi:10.1001/jama.2018.14414

This study describes childbearing and family leave at 15 graduate medical education (GME)–sponsoring institutions affiliated with 12 US medical schools on top 10 lists for funding or ranking.

Specialty Board Leave Policies for Resident Physicians Requesting Parental Leave

Abstract Full Text
free access
JAMA. 2018;320(22):2374-2377. doi:10.1001/jama.2018.15889

This study compares family and childbearing leave policies for resident physicians among American Board of Medical Specialty (ABMS) member organizations that set training duration requirements for US residency programs.


Institutional Conflicts of Interest and Public Trust

Abstract Full Text
JAMA. 2018;320(22):2305-2306. doi:10.1001/jama.2018.18482

This Viewpoint discusses recent problems with undisclosed conflicts of interest and proposes broadening disclosure requirements beyond individuals to include the institutions funding the research.

Should Failure to Disclose Significant Financial Conflicts of Interest Be Considered Research Misconduct?

Abstract Full Text
JAMA. 2018;320(22):2307-2308. doi:10.1001/jama.2018.17525

This Viewpoint proposes that failure of authors to completely disclose conflicts of interest (COIs) should be considered a form of research misconduct subject to institutional review and sanctions if appropriate to establish a basic standard of consistent COI reporting.

Monitoring Jet Engines and the Health of People

Abstract Full Text
JAMA. 2018;320(22):2309-2310. doi:10.1001/jama.2018.16558

In this Viewpoint, Eric Topol and Lionel Tarrasenko, a biomedical engineer known for developing early-warning systems in critical care settings, contrast the precision monitoring of jet engines with existing monitoring systems in patients, and discuss how sensors, artificial intelligence, and other contemporary digital technologies used to monitor the maintenance needs of engines can be used to personalize treatment and improve outcomes for patients without generating false alarms.

Expansion of the Medicare 340B Payment Program: Hospital Participation, Prescribing Patterns and Reimbursement, and Legal Challenges

Abstract Full Text
JAMA. 2018;320(22):2311-2312. doi:10.1001/jama.2018.15667

In this Viewpoint, the authors review Medicare & Medicaid Services 340B Payment program and recent rules to curtail expansion of drug discounts beyond serving poor patients.

A Piece of My Mind

Against the Odds

Abstract Full Text
JAMA. 2018;320(22):2313-2314. doi:10.1001/jama.2018.17821

In this narrative medicine essay, a pediatrician and PhD-trained epidemiologist considers the personal significance of the statistically rare event that has happened to her and the implications for how she cares for patients and communicates risks to families confronting medical decisions.


Conflicts of Interests, Authors, and Journals: New Challenges for a Persistent Problem

Abstract Full Text
free access
JAMA. 2018;320(22):2315-2318. doi:10.1001/jama.2018.17593

Vitamin D Receptor Agonists for Patients Undergoing Hemodialysis

Abstract Full Text
JAMA. 2018;320(22):2319-2321. doi:10.1001/jama.2018.17477

Intensive Intervention to Improve Outcomes for Patients With COPD

Abstract Full Text
JAMA. 2018;320(22):2322-2324. doi:10.1001/jama.2018.17508
JAMA Guide to Statistics and Methods

Bayesian Hierarchical Models

Abstract Full Text
has audio
JAMA. 2018;320(22):2365-2366. doi:10.1001/jama.2018.17977

This JAMA Guide to Statistics and Methods discusses the use, limitations, and interpretation of Bayesian hierarchical modeling, a statistical procedure that integrates information across multiple levels and uses prior information about likely treatment effects and their variability to estimate true vs random treatment effects.

JAMA Clinical Evidence Synopsis

Treatment of Lower Extremity Superficial Thrombophlebitis

Abstract Full Text
JAMA. 2018;320(22):2367-2368. doi:10.1001/jama.2018.16623

This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of treatment of lower extremity superficial thrombophlebitis on venous thromboembolism and major bleeding.

JAMA Diagnostic Test Interpretation

Serum Creatinine in the Critically Ill Patient With Sepsis

Abstract Full Text
has active quiz
JAMA. 2018;320(22):2369-2370. doi:10.1001/jama.2018.16627

Following esophageal resection for cancer, a 73-year-old man was admitted to the ICU with pneumonia and progressive acute respiratory failure, and he was placed on mechanical ventilation. At day 5, his creatinine level continued to increase. How would you proceed?

Medical News & Perspectives

Is It Possible to Get a Flu Shot Too Early?

Abstract Full Text
JAMA. 2018;320(22):2299-2301. doi:10.1001/jama.2018.18373

This Medical News article examines the ongoing debate about whether people should begin getting immunized against influenza as soon as the vaccine becomes available.

The JAMA Forum

A Smarter War on Drugs

Abstract Full Text
free access
JAMA. 2018;320(22):2301-2302. doi:10.1001/jama.2018.18397
News From the Centers for Disease Control and Prevention

Mumps Outbreak Near Denver

Abstract Full Text
JAMA. 2018;320(22):2304. doi:10.1001/jama.2018.19205

PrEP Disparities

Abstract Full Text
JAMA. 2018;320(22):2304. doi:10.1001/jama.2018.18947
Biotech Innovations

Real-Time Visualization of Bacteria in Lungs

Abstract Full Text
JAMA. 2018;320(22):2303. doi:10.1001/jama.2018.18986

Artificial Intelligence Tools for Sepsis and Cancer

Abstract Full Text
JAMA. 2018;320(22):2303. doi:10.1001/jama.2018.19383
The Arts and Medicine

The Alzheimer’s Poetry Project

Abstract Full Text
JAMA. 2018;320(22):2294-2295. doi:10.1001/jama.2018.16340

This Arts and Medicine essay describes the Alzheimer’s Poetry Project, a program that brings poets and facilitators to dementia care settings to reduce social isolation and nurture creative expression among older adults with cognitive deficits.

Poetry and Medicine


Abstract Full Text
JAMA. 2018;320(22):2382. doi:10.1001/jama.2018.11167
JAMA Revisited

The Progress of Preventive Medicine

Abstract Full Text
JAMA. 2018;320(22):2383. doi:10.1001/jama.2017.12699
JAMA Patient Page

Rhytidectomy (Face-Lift Surgery)

Abstract Full Text
free access
JAMA. 2018;320(22):2387. doi:10.1001/jama.2018.17292

This JAMA Patient Page describes the rhytidectomy procedure.

Comment & Response

Third Molar Extraction and Persistent Use of Opioids

Abstract Full Text
JAMA. 2018;320(22):2377. doi:10.1001/jama.2018.17187

Third Molar Extraction and Persistent Use of Opioids—Reply

Abstract Full Text
JAMA. 2018;320(22):2377-2378. doi:10.1001/jama.2018.17203

Potential Harms of HIPAA

Abstract Full Text
JAMA. 2018;320(22):2378-2379. doi:10.1001/jama.2018.17183

Potential Harms of HIPAA

Abstract Full Text
JAMA. 2018;320(22):2379. doi:10.1001/jama.2018.17179

Potential Harms of HIPAA—Reply

Abstract Full Text
JAMA. 2018;320(22):2379-2380. doi:10.1001/jama.2018.17199

Failure to Disclose Conflict of Interest in Article Published in JAMA on Detection of Cancer-Related Genes

Abstract Full Text
JAMA. 2018;320(22):2380. doi:10.1001/jama.2018.16961

Missing Conflict of Interest Disclosure

Abstract Full Text
free access
JAMA. 2018;320(22):2381. doi:10.1001/jama.2018.17511

Incorrect Grant Number

Abstract Full Text
free access
JAMA. 2018;320(22):2381. doi:10.1001/jama.2018.18972

Error in Data Presentation in Text and Table

Abstract Full Text
free access
JAMA. 2018;320(22):2381. doi:10.1001/jama.2018.17985

Incorrect Affiliation and Text Deletion

Abstract Full Text
free access
JAMA. 2018;320(22):2381. doi:10.1001/jama.2018.19038
JAMA Masthead


Abstract Full Text
free access
JAMA. 2018;320(22):2287-2288. doi:10.1001/jama.2017.12670