This randomized clinical trial compares the effect of escitalopram vs placebo on long-term major adverse cardiovascular events among patients in Korea with depression following acute coronary syndrome.
This cohort study determines the risk-adjusted association between completing a 1-hour pediatric sepsis bundle and individual bundle elements with in-hospital mortality following statewide mandated care for pediatric sepsis in New York.
This randomized clinical trial investigates whether early in-bed leg cycling plus electrical stimulation of the quadriceps muscles added to standardized early rehabilitation would result in greater muscle strength at discharge from the intensive care unit compared with standardized early rehabilitation alone in critically ill adult patients treated at one 1100-bed hospital in France.
This study characterizes participation of skilled nursing facilities in Medicare’s Model 3 Bundled Payments for Care Improvement (BPCI) initiative and the factors associated with that participation.
This statement from the International Antiviral Society–USA updates recommendations for the use of antiretroviral drugs to treat adults with established HIV infection and to prevent HIV infection among persons at risk.
This Viewpoint discusses the ethical challenge of defining death in persons with irreversible coma, legalization of the definition of brain death in the 1981 Uniform Determination of Death Act, and current implications of the definition for decisions about life support, organ transplantation, and newer genetic technologies.
This Viewpoint describes the FDA’s guidance on digital tools that seeks to balance technological innovation with assurances that medical mobile apps and other devices that fall within the agency’s regulatory purview are safe and effective.
This Viewpoint discusses the importance of oral medicine to overall patient health, and argues for dedicated screening and assessment of oral and dental health among nondentist health practitioners.
This Viewpoint discusses policy-oriented strategies to help promote a healthier food supply and improve the quality of US diets to help prevent disease.
In this narrative medicine essay, the author considers the words used to describe the tension between shouldering the complex and painful realities of patients while simultaneously facing equally complex and painful family matters—burnout, balance, self-care—inadequate in helping physicians regain equilibrium.
This JAMA Clinical Update reviews the features of commercially available intrauterine devices (IUDs) and progestin implants, misunderstanding about their safety, noncontraceptive benefits, and how to select the form of long-acting reversible contraception (LARC) best for an individual patient.
This Medical Letter review discusses the mechanism of action, adverse effects, and cost associated with coagulation factor Xa that was approved by the US Food and Drug Administration for reversal of the anticoagulant effect of the direct factor Xa inhibitors apixaban and rivaroxaban.
This Medical News article discusses progress and future goals for eliminating the disease.
This JAMA Patient Page describes shingles, the shingles vaccine, and who should be vaccinated against shingles.