This randomized clinical trial compares the effects of a 36-month multicomponent behavioral intervention for obesity prevention vs a school-readiness control on body mass index (BMI) trajectories in underserved preschool-age children at risk for obesity but not yet obese.
This randomized clinical trial compares the effects of a responsive parenting intervention designed to promote developmentally appropriate, prompt, and contingent responses to an infant’s needs vs a home safety intervention on child weight outcomes at 3 years.
This cohort study examines associations between use of broad-based genomic screening vs routine testing (for EGFR and ALK alterations only) to target treatment of advanced non–small cell lung cancer and mortality at 1 year and overall survival.
This pharmacoepidemiology study uses commercial claims database data to describe the rate of opioid overdose 1 to 3 months after surgical discharge by dose and procedure from 2004 to 2015.
This pharmacoepidemiology study uses commercial claims database data to describe the rate of persistent opioid use among patients aged 13 to 30 years prescribed perioperative opioids for wisdom tooth extraction.
This 2018 Recommendation Statement from the US Preventive Services Task Force concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for atrial fibrillation (AF) with ECG (I statement).
This systematic review to support the 2018 US Preventive Services Task Force Recommendation Statement on screening for atrial fibrillation (AF) with electrocardiography (ECG) summarizes published evidence on the benefits and harms of screening and treatment of nonvalvular AF in asymptomatic adults 65 years and older.
This Viewpoint reviews what is known about myocardial infarction (MI) caused by oxygen supply-and-demand mismatch (type 2 MI) and differences from MI caused by coronary artery disease, as well as proposes areas for further investigation to identify optimal management strategies.
This Viewpoint encourages the development of approaches to share the results of research with study participants to reinforce the value of patient participation, to incentivize engagement in research, and to honor the belief that individuals have a right to their own data.
This Viewpoint discusses progress in the recognition and management of acute kidney injury (AKI) since publication in 2012 of KDIGO clinical practice guidelines to improve AKI outcomes, and proposes next steps in management, including use of biomarkers, risk alerts, and care bundles, to improve AKI prevention and outcomes.
This Viewpoint uses the case of an NIH trial funded by alcohol manufacturers and designed to determine the effects of moderate alcohol consumption on health outcomes to discuss the need for transparency in NIH-private partnerships and ways the NIH can administer those partnerships to preserve its integrity and trustworthiness.
In this narrative medicine essay, a medical student is reminded of Communion service at her New England Protestant church when she sees the beauty of the human anatomy in a cadaver, a former teacher who offered her body as the ultimate teaching moment, in an echo of Jesus’ words at the Last Supper: “This is my body, broken for you. Do this in memory of me.”
This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of co-administration of an antibiotic and a probiotic vs placebo or no treatment in adults and children diagnosed with Clostridium difficile infection.
This Medical News story examines the controversy surrounding crisis pregnancy centers.
This JAMA Patient Page describes the US Preventive Services Task Force’s recommendations on screening for atrial fibrillation using electrocardiography.
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