In this Viewpoint, Roger I. Glass traces the discovery of the oral rehydration solution during a cholera epidemic in Bangladesh in the 1960s to treat severe diarrhea by promoting electrolyte balance and attributes oral rehydration therapy with saving hundreds of thousands of lives in the last 50 years.
In this Viewpoint, Janet Woodcock and CDER colleagues discuss recent FDA initiatives to investigate the adequacy of electronic health record (EHR) and patient database data for research purposes and to understand if and how real-world observational data might be analyzed in ways that mimic or can be as reliable as randomized trials.
This Viewpoint reviews provisions of the US Right to Try Act, which allows patients with life-threatening conditions access to investigational drugs without FDA approval, and calls for clarifications around patient and drug eligibility, reporting requirements, and differences from the FDA’s Expanded Access program to minimize potential harms from the law.
This JAMA Viewpoint discusses trends towards implementing palliative care for patients with serious chronic illness earlier than end of life, and it highlights challenges around the use of opioids for pain control in this broader population of patients due to longer periods of use and greater likelihood of mood and substance use disorders.
This Viewpoint summarizes the scope, perspective, and recommendations of a National Academies of Sciences, Engineering, and Medicine (NASEM) 2018 report on climate, culture, and consequences of sexual harassment of women in the academic sciences.
In this narrative medicine essay, the author, who transitioned from paper and pen to computer-generated electronic health record keeping, wonders whether self-select menu items on the EHR ultimately dehumanize both the patient and the physician.
This randomized trial compares the effects of immediate vs gradual vs no reduction in nicotine content on breath carbon monoxide (CO) measures and other biomarkers of cigarette smoke exposure.
This study compares patient discharges to postacute care facilities after lower extremity joint replacement and spending among hospitals mandated vs not mandated by the Centers for Medicare & Medicaid Services to participate in a bundled payment model.
This before-after study uses Centers for Medicare and Medicaid Services’ (CMS’s) claims data to compare changes in lower extremity joint replacement surgery volume and case mix associated with participation vs nonparticipation in CMS' Bundled Payments for Care Improvement program.
This 2018 update to the US Preventive Services Task Force statement on screening for syphilis in pregnant women reaffirms a prior recommendation to screen for the infection early in all pregnant women (A recommendation).
This systematic review to support the 2018 updated US Preventive Services Task Force Recommendation Statement on screening for syphilis infection in pregnant women summarizes published evidence on the effectiveness and harms of screening for syphilis, and the harms of penicillin treatment for syphilis, during pregnancy.
This Medical Letter review summarizes information regarding the effectiveness, adverse effects, and potential drug interactions of transdermal, oral, and nasal spray formulations of nicotine replacement therapies and of smoking cessation drugs bupropion and varenicline.
This study uses Medicare part B billing data to compare trends in the use of filgrastim and its biosimilars among beneficiaries between 2014 and 2016.
This study estimates mean 2017 total and out-of-pocket costs for infliximab and its biosimilar infliximab-dyyb under Medicare Part D.
In this Medical News article, researchers discuss the outlook for developing effective therapeutic vaccines to treat ovarian cancer.
In this Medical News & Perspectives article, a US Navy flight surgeon talks about caring for sailors, heading out to sea, and learning to fly. The story is part of an ongoing JAMA News series profiling the daily routine of health care professionals making a difference in their communities.
This JAMA Patient Page describes the US Preventive Services Task Force’s recent recommendations on screening for syphilis infection in pregnant women.
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