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February 2019 - July 1883




September 4, 2018, Vol 320, No. 9, Pages 849-948

In This Issue of JAMA


Abstract Full Text
free access has audio
JAMA. 2018;320(9):849-851. doi:10.1001/jama.2017.12526

Oral Rehydration Therapy for Diarrheal Diseases: A 50-Year Perspective

Abstract Full Text
JAMA. 2018;320(9):865-866. doi:10.1001/jama.2018.10963

In this Viewpoint, Roger I. Glass traces the discovery of the oral rehydration solution during a cholera epidemic in Bangladesh in the 1960s to treat severe diarrhea by promoting electrolyte balance and attributes oral rehydration therapy with saving hundreds of thousands of lives in the last 50 years.

Real-World Evidence and Real-World Data for Evaluating Drug Safety and Effectiveness

Abstract Full Text
JAMA. 2018;320(9):867-868. doi:10.1001/jama.2018.10136

In this Viewpoint, Janet Woodcock and CDER colleagues discuss recent FDA initiatives to investigate the adequacy of electronic health record (EHR) and patient database data for research purposes and to understand if and how real-world observational data might be analyzed in ways that mimic or can be as reliable as randomized trials.

Promoting Patient Interests in Implementing the Federal Right to Try Act

Abstract Full Text
JAMA. 2018;320(9):869-870. doi:10.1001/jama.2018.9880

This Viewpoint reviews provisions of the US Right to Try Act, which allows patients with life-threatening conditions access to investigational drugs without FDA approval, and calls for clarifications around patient and drug eligibility, reporting requirements, and differences from the FDA’s Expanded Access program to minimize potential harms from the law.

Use of Palliative Care Earlier in the Disease Course in the Context of the Opioid Epidemic: Educational, Research, and Policy Issues

Abstract Full Text
JAMA. 2018;320(9):871-872. doi:10.1001/jama.2018.9739

This JAMA Viewpoint discusses trends towards implementing palliative care for patients with serious chronic illness earlier than end of life, and it highlights challenges around the use of opioids for pain control in this broader population of patients due to longer periods of use and greater likelihood of mood and substance use disorders.

National Academies of Sciences, Engineering, and Medicine Report on Sexual Harassment: Making the Case for Fundamental Institutional Change

Abstract Full Text
JAMA. 2018;320(9):873-874. doi:10.1001/jama.2018.10840

This Viewpoint summarizes the scope, perspective, and recommendations of a National Academies of Sciences, Engineering, and Medicine (NASEM) 2018 report on climate, culture, and consequences of sexual harassment of women in the academic sciences.

A Piece of My Mind

Good Documentation

Abstract Full Text
JAMA. 2018;320(9):875-876. doi:10.1001/jama.2018.11781

In this narrative medicine essay, the author, who transitioned from paper and pen to computer-generated electronic health record keeping, wonders whether self-select menu items on the EHR ultimately dehumanize both the patient and the physician.


Medicare Bundled Payment Programs for Joint Replacement: Anatomy of a Successful Payment Reform

Abstract Full Text
JAMA. 2018;320(9):877-879. doi:10.1001/jama.2018.11787
Original Investigation

Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial

Abstract Full Text
has active quiz has multimedia
JAMA. 2018;320(9):880-891. doi:10.1001/jama.2018.11473

This randomized trial compares the effects of immediate vs gradual vs no reduction in nicotine content on breath carbon monoxide (CO) measures and other biomarkers of cigarette smoke exposure.

Mandatory Medicare Bundled Payment Program for Lower Extremity Joint Replacement and Discharge to Institutional Postacute Care: Interim Analysis of the First Year of a 5-Year Randomized Trial

Abstract Full Text
has active quiz
JAMA. 2018;320(9):892-900. doi:10.1001/jama.2018.12346

This study compares patient discharges to postacute care facilities after lower extremity joint replacement and spending among hospitals mandated vs not mandated by the Centers for Medicare & Medicaid Services to participate in a bundled payment model.

Association of Hospital Participation in a Medicare Bundled Payment Program With Volume and Case Mix of Lower Extremity Joint Replacement Episodes

Abstract Full Text
JAMA. 2018;320(9):901-910. doi:10.1001/jama.2018.12345

This before-after study uses Centers for Medicare and Medicaid Services’ (CMS’s) claims data to compare changes in lower extremity joint replacement surgery volume and case mix associated with participation vs nonparticipation in CMS' Bundled Payments for Care Improvement program.

US Preventive Services Task Force

Recommendation Statement

Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement

Abstract Full Text
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JAMA. 2018;320(9):911-917. doi:10.1001/jama.2018.11785

This 2018 update to the US Preventive Services Task Force statement on screening for syphilis in pregnant women reaffirms a prior recommendation to screen for the infection early in all pregnant women (A recommendation).

Evidence Report

Screening for Syphilis Infection in Pregnant Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Abstract Full Text
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JAMA. 2018;320(9):918-925. doi:10.1001/jama.2018.7769

This systematic review to support the 2018 updated US Preventive Services Task Force Recommendation Statement on screening for syphilis infection in pregnant women summarizes published evidence on the effectiveness and harms of screening for syphilis, and the harms of penicillin treatment for syphilis, during pregnancy.

From The Medical Letter on Drugs and Therapeutics

Drugs for Tobacco Dependence

Abstract Full Text
JAMA. 2018;320(9):926-927. doi:10.1001/jama.2018.12463

This Medical Letter review summarizes information regarding the effectiveness, adverse effects, and potential drug interactions of transdermal, oral, and nasal spray formulations of nicotine replacement therapies and of smoking cessation drugs bupropion and varenicline.

Research Letter

Uptake of the Biologic Filgrastim and Its Biosimilar Product Among the Medicare Population

Abstract Full Text
JAMA. 2018;320(9):929-931. doi:10.1001/jama.2018.9014

This study uses Medicare part B billing data to compare trends in the use of filgrastim and its biosimilars among beneficiaries between 2014 and 2016.

Out-of-Pocket Costs for Infliximab and Its Biosimilar for Rheumatoid Arthritis Under Medicare Part D

Abstract Full Text
JAMA. 2018;320(9):931-933. doi:10.1001/jama.2018.7316

This study estimates mean 2017 total and out-of-pocket costs for infliximab and its biosimilar infliximab-dyyb under Medicare Part D.

Medical News & Perspectives

Pursuing an Effective Ovarian Cancer Vaccine

Abstract Full Text
JAMA. 2018;320(9):858-860. doi:10.1001/jama.2018.10822

In this Medical News article, researchers discuss the outlook for developing effective therapeutic vaccines to treat ovarian cancer.

A Day in the Life: Navy Flight Surgeon Handles Helicopters and Sailors’ Ills

Abstract Full Text
JAMA. 2018;320(9):860-861. doi:10.1001/jama.2018.11451

In this Medical News & Perspectives article, a US Navy flight surgeon talks about caring for sailors, heading out to sea, and learning to fly. The story is part of an ongoing JAMA News series profiling the daily routine of health care professionals making a difference in their communities.

News From the Food and Drug Administration

New Endometriosis Drug Approved

Abstract Full Text
JAMA. 2018;320(9):864. doi:10.1001/jama.2018.12146

When Is Milk Really Milk?

Abstract Full Text
JAMA. 2018;320(9):864. doi:10.1001/jama.2018.12148

Magnetic Tracer System Identifies Sentinel Lymph Nodes

Abstract Full Text
JAMA. 2018;320(9):864. doi:10.1001/jama.2018.12152
Bench to Bedside

Research Reveals Mechanism That May Drive Alcohol Use Disorder

Abstract Full Text
JAMA. 2018;320(9):862-863. doi:10.1001/jama.2017.12864
Comment & Response

SMART in the Management of Patients With Persistent Asthma

Abstract Full Text
JAMA. 2018;320(9):933-934. doi:10.1001/jama.2018.8573

SMART in the Management of Patients With Persistent Asthma—Reply

Abstract Full Text
JAMA. 2018;320(9):934. doi:10.1001/jama.2018.8577

Lowering the P Value Threshold

Abstract Full Text
JAMA. 2018;320(9):934-935. doi:10.1001/jama.2018.8721

Lowering the P Value Threshold

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JAMA. 2018;320(9):935-936. doi:10.1001/jama.2018.8729

Lowering the P Value Threshold

Abstract Full Text
JAMA. 2018;320(9):935. doi:10.1001/jama.2018.8733

Lowering the P Value Threshold

Abstract Full Text
JAMA. 2018;320(9):936. doi:10.1001/jama.2018.8717

Lowering the P Value Threshold

Abstract Full Text
JAMA. 2018;320(9):936-937. doi:10.1001/jama.2018.8725

Lowering the P Value Threshold—Reply

Abstract Full Text
JAMA. 2018;320(9):937-938. doi:10.1001/jama.2018.8743

Incorrect Medication Reported

Abstract Full Text
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JAMA. 2018;320(9):938. doi:10.1001/jama.2018.11607

Error in Figure

Abstract Full Text
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JAMA. 2018;320(9):938. doi:10.1001/jama.2018.11635
Poetry and Medicine


Abstract Full Text
JAMA. 2018;320(9):939. doi:10.1001/jama.2018.5075
JAMA Revisited

The Dietary Habits of American College Girls

Abstract Full Text
JAMA. 2018;320(9):940. doi:10.1001/jama.2017.12556
JAMA Patient Page

Screening for Syphilis in Pregnant Women

Abstract Full Text
free access
JAMA. 2018;320(9):948. doi:10.1001/jama.2018.12119

This JAMA Patient Page describes the US Preventive Services Task Force’s recent recommendations on screening for syphilis infection in pregnant women.

JAMA Masthead


Abstract Full Text
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JAMA. 2018;320(9):853-854. doi:10.1001/jama.2017.12527