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September 2019 - July 1883




March 12, 2019, Vol 321, No. 10, Pages 913-1014

In This Issue of JAMA


Abstract Full Text
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JAMA. 2019;321(10):913-915. doi:10.1001/jama.2018.15234
Original Investigation

Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial

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JAMA. 2019;321(10):946-955. doi:10.1001/jama.2019.1113

This randomized clinical trial compares the efficacy and safety of epicutaneous immunotherapy with a peanut patch vs placebo among peanut-allergic children.

Association of Midlife Diet With Subsequent Risk for Dementia

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JAMA. 2019;321(10):957-968. doi:10.1001/jama.2019.1432

This Whitehall II cohort study examines whether midlife diet assessed using the Alternate Healthy Eating Index, a food frequency questionnaire, is associated with subsequent risk for dementia in UK civil servants.

Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis

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JAMA. 2019;321(10):969-982. doi:10.1001/jama.2019.1347

This cohort study uses EHR data from the practices of UK general practitioners to examine the association between an initial prescription for tramadol and all-cause mortality relative to other commonly prescribed NSAIDs (naproxen, diclofenac, celecoxib, etoricoxib) and codeine in patients with osteoarthritis (OA).

Research Letter

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

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JAMA. 2019;321(10):1003-1005. doi:10.1001/jama.2019.0052

This long-term follow-up of a randomized trial reporting no apparent effect of high-dose vs standard-dose prenatal vitamin D supplementation on wheezing in children at the age of 3 years extends the findings an additional 3 years and describes asthma risk at the age of 6 years.

Special Communication

Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference

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JAMA. 2019;321(10):983-997. doi:10.1001/jama.2019.0554

This guideline statement describes development of evidence-based recommendations for detection and management of preoperative anemia, red blood cell (RBC) transfusion, and implementation of patient blood management programs.


Trust in Health Care

Building Trust Between Physicians, Hospitals, and Payers: A Renewed Opportunity for Transforming US Health Care

Abstract Full Text
JAMA. 2019;321(10):933-934. doi:10.1001/jama.2018.19357

As health care costs continue to rise and health system and insurance entities undergo major changes, mistrust and tension has arisen between payers vs physicians and hospitals. This Viewpoint explains the reasons for these tensions, the perspectives of both sides, and proposed and existing solutions for transforming US health care.

Optimizing the Timing of Vaccine Administration During Pregnancy

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JAMA. 2019;321(10):935-936. doi:10.1001/jama.2019.0703

This Viewpoint reviews variables influencing the optimal timing of prenatal vaccination, including difference by trimester in vaccine fetal safety, maternal disease susceptibility and immune response, and maternal access to uptake of immunization.

Firearm Policies That Work

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JAMA. 2019;321(10):937-938. doi:10.1001/jama.2019.0706

This Viewpoint reports on research that shows reductions in firearm-related homicides in states and counties that have enacted laws restricting firearm access to individuals with a history of violence, restraining orders, or convictions for violent acts including misdemeanor violence and calls for policies with taut oversight systems restricting firearm access to high-risk individuals.

Maryland Total Cost of Care Model: Transforming Health and Health Care

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JAMA. 2019;321(10):939-940. doi:10.1001/jama.2019.0895

This Viewpoint reviews the Centers for Medicare & Medicaid Services’ (CMS’) Total Cost of Care agreement with Maryland, which incentivizes the state in a demonstration project over 8-years to coordinate care among hospitals, clinics, physicians, and clinicians and ensure that upfront care reduces avoidable costly care later.

A Piece of My Mind

Wearing Two Hats

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JAMA. 2019;321(10):941-942. doi:10.1001/jama.2019.1323

In this narrative medicine essay, a palliative care physician shares the story of his 100-year-old grandmother’s last moments surrounded by family and love.


Safeguarding the Patient’s Own Blood Supply

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JAMA. 2019;321(10):943-945. doi:10.1001/jama.2019.0553
JAMA Clinical Challenge

Abdominal Pain and Vomiting in a Pregnant Woman Who Has Had a Gastric Bypass Procedure

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JAMA. 2019;321(10):998-999. doi:10.1001/jama.2017.18946

A 31-year-old G2P1 woman who had undergone gastric bypass 4 years prior and is 36 weeks pregnant presents with acute abdominal signs and symptoms that persist after an uncomplicated delivery; a CT scan reveals mesenteric vascular compromise. What is the diagnosis and what would you do next?

From The Medical Letter on Drugs and Therapeutics

Dupilumab (Dupixent) for Asthma

Abstract Full Text
JAMA. 2019;321(10):1000-1001. doi:10.1001/jama.2019.0080

This Medical Letter review summarizes doses and formulations of dupilumab (Dupixent), a subcutaneously injected monoclonal antibody add-on maintenance treatment approved for patients aged 12 years or older with moderate to severe asthma with an eosinophilic phenotype or with oral corticosteroid-dependent asthma.

Editor's Note

Epicutaneous Immunotherapy vs Placebo for Peanut Protein Ingestion Among Peanut-Allergic Children

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JAMA. 2019;321(10):956. doi:10.1001/jama.2019.1133
Medical News & Perspectives

Addressing Medicine’s Bias Against Patients Who Are Overweight

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JAMA. 2019;321(10):925-927. doi:10.1001/jama.2019.0048

This Medical News story examines the roots of and potential corrective measures for weight bias in health care settings.

Quick Uptakes: No Compelling Evidence of Health Benefits From Nonsugar Sweeteners

Abstract Full Text
JAMA. 2019;321(10):927-928. doi:10.1001/jama.2019.0430

This Medical News article discusses a recent systematic review of evidence on health outcomes associated with nonsugar sweeteners.

The JAMA Forum

Immigrant Health, Value-Based Care, and Emergency Medicaid Reform

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JAMA. 2019;321(10):928-929. doi:10.1001/jama.2019.0839
News From the Centers for Disease Control and Prevention

School-Associated Youth Homicides

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JAMA. 2019;321(10):931. doi:10.1001/jama.2019.1318

Transgender Youth Victimization

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JAMA. 2019;321(10):931. doi:10.1001/jama.2019.1463
Biotech Innovations

Fit-Testing Transcatheter Aortic Valve Replacements With 3-D Printing

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JAMA. 2019;321(10):930. doi:10.1001/jama.2019.1352

Liver and Lung Transplant Advances

Abstract Full Text
JAMA. 2019;321(10):930. doi:10.1001/jama.2017.7155
Poetry and Medicine

All Hands

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JAMA. 2019;321(10):1009. doi:10.1001/jama.2018.17851
JAMA Revisited

Saccharin—After the War

Abstract Full Text
JAMA. 2019;321(10):1010. doi:10.1001/jama.2018.15242
JAMA Patient Page

Meningococcal Meningitis

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JAMA. 2019;321(10):1014. doi:10.1001/jama.2019.0772

This JAMA Patient Page describes meningococcal meningitis, its causes, risk factors, and prevention measures.

Comment & Response

Excess Deaths After Hurricane Maria in Puerto Rico

Abstract Full Text
JAMA. 2019;321(10):1005. doi:10.1001/jama.2018.20861

Excess Deaths After Hurricane Maria in Puerto Rico—Reply

Abstract Full Text
JAMA. 2019;321(10):1005-1006. doi:10.1001/jama.2018.20878

Inferior Vena Cava Filters in the Management of Venous Thromboembolism

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JAMA. 2019;321(10):1006. doi:10.1001/jama.2018.21123

Inferior Vena Cava Filters in the Management of Venous Thromboembolism—Reply

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JAMA. 2019;321(10):1007. doi:10.1001/jama.2018.21127

Errors in Analysis of Mean Deviations in Study of Photocoagulation vs Ranibizumab for Diabetic Retinopathy

Abstract Full Text
JAMA. 2019;321(10):1007-1008. doi:10.1001/jama.2019.0374
JAMA Masthead


Abstract Full Text
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JAMA. 2019;321(10):917-918. doi:10.1001/jama.2018.15235