This randomized trial compares the effects of 2 15-second sustained inflations vs standard intermittent positive pressure ventilation on the risk of bronchopulmonary dysplasia or death at 36 weeks’ postmenstrual age in extremely preterm infants.
This phase 2 clinical trial investigates whether injecting the myocardium of patients with heart failure with a high dose of mesenchymal precursor cells derived from bone marrow stem cells, compared with a sham injection, repairs myocardial damage enough to facilitate weaning from left ventricular assist devices (LVADs).
This population epidemiology study uses Swedish national registry data to compare 1-year survival of extremely preterm infants born at 22-26 weeks’ gestational age during 2004-2007 vs those born during 2014-2016 after the release of a national consensus guideline on perinatal management.
This study reviews protocols for treating convulsive status epilepticus from 33 emergency medical services systems in California to determine if they had incorporated updated evidence-based guidelines.
In this Viewpoint, Ezekiel Emanuel and colleagues make policy recommendations to control continued growth in health care spending, including national US drug price negotiation, linking benchmarks for cost growth to economic growth and population aging, expansion of alternative payment models to private health care markets, and federal antitrust legislation to address market consolidation that reduces competition and increases prices.
This Viewpoint discusses 3 challenges that need to be overcome to meet the new US goal of reducing HIV transmissions to zero by 2030: prevention in high-risk communities, reducing infected individuals’ viral loads to undetectable levels, and addressing socioeconomic, racial, and geographic HIV-associated disparities.
This Viewpoint reviews measles outbreaks in the United States since the year 2000 attributable to vaccine hesitancy, refusal, and exemption, and specifies the costs to individuals, society, and health systems as a result.
This Viewpoint discusses the Merit-Based Incentive Payment System (MIPS), a CMS pay-for-performance (P4P) initiative that rewards clinicians for quality care and for promoting EHR interoperability, and it reviews the shortcomings and complexity of the measures and proposes alternative mechanisms to incentivize quality.
In this narrative medicine essay, a pediatric psychiatrist describes his experience arranging psychotherapy, his fear of what his peers or patients might say, and his surprise that his willingness to share his emotional vulnerabilities in the proces has given him deeper and more rewarding relationships personally and professionally.
This narrative review examines (1) the epidemiology, causes, and management of in-hospital cardiac arrest and (2) strategies and quality-improvement initiatives proposed to prevent its occurrence and improve outcomes.
This Guide to Statistics and Methods discusses analytical approaches to accounting for differences in treatment effect by study center when randomized trials enroll patients and administer interventions at multiple sites.
A 22-year-old man had an 8-year history of painful, asymmetrically grouped lesions on his right flank. The cluster contained verrucous papules and plaques in the center and vesicles filled with clear and milky-white fluid in the periphery, with partial crusting of some lesions. What is the diagnosis and what would you do next?
This Medical News article is a physician’s first-person account of last November’s Camp Fire.
This Medical News feature discusses findings from a recent study on the prevalence of adult-onset food allergies and the potential reasons behind them.
This JAMA Patient Page explains the use of thyroglobulin measurement to monitor for recurrence in patients who have had thyroid cancer.
Notice of Retraction and Replacement. Dyrbye et al. Association of clinical specialty with symptoms of burnout and career choice regret among US resident physicians. JAMA. 2018;320(11):1114-1130