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September 2019 - July 1883




April 9, 2019, Vol 321, No. 14, Pages 1325-1418

In This Issue of JAMA


Abstract Full Text
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JAMA. 2019;321(14):1325-1327. doi:10.1001/jama.2018.15278
Original Investigation

Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers: The AMATERASU Randomized Clinical Trial

Abstract Full Text
has active quiz has multimedia
JAMA. 2019;321(14):1361-1369. doi:10.1001/jama.2019.2210

This randomized clinical trial compares the effects of vitamin D supplementation vs placebo on 5-year relapse-free survival after surgical resection of stage I-III esophageal, gastric, small bowel, and colorectal cancers.

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial

Abstract Full Text
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JAMA. 2019;321(14):1370-1379. doi:10.1001/jama.2019.2402

This phase 2 randomized clinical trial compares the effects of high-dose vs standard-dose vitamin D3 added to standard chemotherapy on progression-free survival among patients with metastatic colorectal cancer.

Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection

Abstract Full Text
has active quiz
JAMA. 2019;321(14):1380-1390. doi:10.1001/jama.2019.2947

To evaluate the possibility that HIV preexposure prophylaxis (PrEP) might lead to behavioral changes that increase risk of non-HIV sexually transmitted infections (STIs), this cohort study investigates the incidence of chlamydia, gonorrhea, and syphilis among a population of Australian gay and bisexual men before and after initiation of HIV PrEP.

Association of Patient Characteristics and Tumor Genomics With Clinical Outcomes Among Patients With Non–Small Cell Lung Cancer Using a Clinicogenomic Database

Abstract Full Text
JAMA. 2019;321(14):1391-1399. doi:10.1001/jama.2019.3241

This cancer epidemiology study links electronic health record (EHR) data with comprehensive genomic profiling to identify patient characteristics and gene alterations associated with overall survival, response to targeted and immune therapies, and other clinical outcomes in patients non–small cell lung cancer (NSCLC).

Research Letter

Nurse Practitioner and Physician Assistant Waivers to Prescribe Buprenorphine and State Scope of Practice Restrictions

Abstract Full Text
JAMA. 2019;321(14):1407-1408. doi:10.1001/jama.2019.0834

This study uses SAMHSA data to describe the proportions of nurse practitioners and physician assistants with waivers to prescribe buprenorphine for treating opioid use disorder and associations with state regulations restricting their scope of practice.


Trust in Health Care

Physicians’ Trust in One Another

Abstract Full Text
JAMA. 2019;321(14):1345-1346. doi:10.1001/jama.2018.20569

This Viewpoint discusses the importance of trust between physicians for ensuring quality care and reducing physician burnout; shares physicians’ stories about trust and mistrust of their peers and colleagues; and proposes a set of initial principles intended to foster physician-physician trust.

Trust in Health Care

Why Physicians Should Trust in Patients

Abstract Full Text
JAMA. 2019;321(14):1347-1348. doi:10.1001/jama.2019.1500

This Viewpoint discusses the importance of reciprocal trust between patients and physicians, identifies reasons physicians may not trust their patients, and proposes ways physicians can communicate their trust directly to patients.

Obesity Treatment, Beyond the Guidelines: Practical Suggestions for Clinical Practice

Abstract Full Text
JAMA. 2019;321(14):1349-1350. doi:10.1001/jama.2019.2352

This Viewpoint proposes a guideline-based approach to weight management counseling in primary care, emphasizing the need to avoid stigmatizing overweight and obesity, and the need for physician persistence in offering patients their attention, support, and individualized treatment.

Nutrition Education in Medical School, Residency Training, and Practice

Abstract Full Text
JAMA. 2019;321(14):1351-1352. doi:10.1001/jama.2019.1581

This Viewpoint discusses the lack of nutrition education offered to medical students, despite the important role that physicians can and should play in advising patients on the topic, and proposes ways to integrate meaningful nutrition instruction into all phases of medical training.

A Piece of My Mind

Having the Conversation I Encourage Others to Have

Abstract Full Text
JAMA. 2019;321(14):1353. doi:10.1001/jama.2019.3166

In this narrative medicine essay, a palliative care physician with breast cancer talks about the end-of-life conversations she and her husband have, recalling how her priorities have changed through life stages and how she uses her experiences to inform her interactions with her own cancer patients.


Vitamin D as Cancer Therapy?Insights From 2 New Trials

Abstract Full Text
has multimedia has audio
JAMA. 2019;321(14):1354-1355. doi:10.1001/jama.2019.2589

Addressing the Sexually Transmitted Infection and HIV Syndemic

Abstract Full Text
JAMA. 2019;321(14):1356-1358. doi:10.1001/jama.2019.2945

The Evolving Uses of “Real-World” Data

Abstract Full Text
JAMA. 2019;321(14):1359-1360. doi:10.1001/jama.2019.4064
JAMA Guide to Statistics and Methods

Overview of Cost-effectiveness Analysis

Abstract Full Text
JAMA. 2019;321(14):1400-1401. doi:10.1001/jama.2019.1265

This JAMA Guide to Statistics and Methods reviews the use of cost-effectiveness analysis to quantify the tradeoffs in costs, harms, and benefits of new health care interventions compared with existing interventions.

JAMA Performance Improvement

Reducing Emergency Department Length of Stay

Abstract Full Text
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JAMA. 2019;321(14):1402-1403. doi:10.1001/jama.2018.21812

This JAMA Performance Improvement article uses the case of a patient who presented to the emergency department but left after waiting 4 hours without being seen to discuss interdisciplinary improvement efforts for reducing system inefficiencies and improving access to care in emergency departments.

JAMA Diagnostic Test Interpretation

Evaluating the Erythrocyte Sedimentation Rate

Abstract Full Text
has active quiz
JAMA. 2019;321(14):1404-1405. doi:10.1001/jama.2019.1178

A 65-year-old woman presented with 2 days of throbbing, bilateral temporal headache and bilateral blurred vision, an erythrocyte sedimentation rate (ESR) of 110 mm/h, and total protein of 10.4 g/dL. Results of a temporal artery biopsy showed a normal caliber lumen without infiltrating inflammatory cells. What is the diagnosis, and what would you do next?

Medical News & Perspectives

Mesh Implants for Women: Scandal or Standard of Care?

Abstract Full Text
JAMA. 2019;321(14):1338-1340. doi:10.1001/jama.2019.0940

This Medical News story examines the controversy over the safety and effectiveness of mesh implants used to treat pelvic organ prolapse and stress urinary incontinence.

Quick Uptakes: Taking the Uncertainty Out of Interpreting BRCA Variants

Abstract Full Text
JAMA. 2019;321(14):1340-1341. doi:10.1001/jama.2019.0967

This Medical News feature provides highlights of a comprehensive international database that can help clinicians and patients clarify the meaning of BRCA1 and BRCA2 genetic variants.

The JAMA Forum

Deprescribing Policies: Time for a Fresh Approach

Abstract Full Text
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JAMA. 2019;321(14):1341-1342. doi:10.1001/jama.2019.2939
News From the Centers for Disease Control and Prevention

Measles Vaccine Exemptions

Abstract Full Text
JAMA. 2019;321(14):1344. doi:10.1001/jama.2019.3063

Vaping and Pregnancy

Abstract Full Text
JAMA. 2019;321(14):1344. doi:10.1001/jama.2019.3424
Biotech Innovations

Better Cholera Counts Through Machine Learning Models

Abstract Full Text
JAMA. 2019;321(14):1343. doi:10.1001/jama.2019.3459

Wireless Vital Signs Monitoring for the NICU

Abstract Full Text
JAMA. 2019;321(14):1343. doi:10.1001/jama.2019.3243

HIV Remission After Hematopoietic Stem Cell Transplant

Abstract Full Text
JAMA. 2019;321(14):1343. doi:10.1001/jama.2019.3460
The Arts and Medicine

Clinical Role-Play in Autonomous Sensory Meridian Response (ASMR) Videos: Performance and Placebo in the Digital Era

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JAMA. 2019;321(14):1336-1337. doi:10.1001/jama.2019.2302

This Arts and Medicine essay describes the growth of clinical role-play ASMR videos online, reviews what little is known about the ASMR phenomenon, and discusses it in the context of placebo response research.

Poetry and Medicine


Abstract Full Text
JAMA. 2019;321(14):1413. doi:10.1001/jama.2018.20560
JAMA Revisited

Green Foods and Vitamins

Abstract Full Text
JAMA. 2019;321(14):1414. doi:10.1001/jama.2018.15286
JAMA Patient Page

Eosinophilic Esophagitis

Abstract Full Text
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JAMA. 2019;321(14):1418. doi:10.1001/jama.2019.1992

This JAMA Patient Page describes the symptoms, diagnosis, and treatment of eosinophilic esophagitis.

Comment & Response

Decontamination Strategies for Critically Ill Patients

Abstract Full Text
JAMA. 2019;321(14):1408-1409. doi:10.1001/jama.2019.0452

Decontamination Strategies for Critically Ill Patients

Abstract Full Text
JAMA. 2019;321(14):1409. doi:10.1001/jama.2019.0448

Decontamination Strategies for Critically Ill Patients

Abstract Full Text
JAMA. 2019;321(14):1409-1410. doi:10.1001/jama.2019.0444

Decontamination Strategies for Critically Ill Patients—Reply

Abstract Full Text
JAMA. 2019;321(14):1410. doi:10.1001/jama.2019.0456

Multifaceted Program to Reduce Job Strain in ICU Nurses

Abstract Full Text
JAMA. 2019;321(14):1410-1411. doi:10.1001/jama.2019.0570

Multifaceted Program to Reduce Job Strain in ICU Nurses—Reply

Abstract Full Text
JAMA. 2019;321(14):1411-1412. doi:10.1001/jama.2019.0580

Incorrect Data in Figure

Abstract Full Text
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JAMA. 2019;321(14):1412. doi:10.1001/jama.2019.3124

Incorrect Word Used

Abstract Full Text
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JAMA. 2019;321(14):1412. doi:10.1001/jama.2019.3270
JAMA Masthead


Abstract Full Text
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JAMA. 2019;321(14):1329-1330. doi:10.1001/jama.2018.15279