This randomized clinical trial compares the effects of vitamin D supplementation vs placebo on 5-year relapse-free survival after surgical resection of stage I-III esophageal, gastric, small bowel, and colorectal cancers.
This phase 2 randomized clinical trial compares the effects of high-dose vs standard-dose vitamin D3 added to standard chemotherapy on progression-free survival among patients with metastatic colorectal cancer.
To evaluate the possibility that HIV preexposure prophylaxis (PrEP) might lead to behavioral changes that increase risk of non-HIV sexually transmitted infections (STIs), this cohort study investigates the incidence of chlamydia, gonorrhea, and syphilis among a population of Australian gay and bisexual men before and after initiation of HIV PrEP.
This cancer epidemiology study links electronic health record (EHR) data with comprehensive genomic profiling to identify patient characteristics and gene alterations associated with overall survival, response to targeted and immune therapies, and other clinical outcomes in patients non–small cell lung cancer (NSCLC).
This study uses SAMHSA data to describe the proportions of nurse practitioners and physician assistants with waivers to prescribe buprenorphine for treating opioid use disorder and associations with state regulations restricting their scope of practice.
This Viewpoint discusses the importance of trust between physicians for ensuring quality care and reducing physician burnout; shares physicians’ stories about trust and mistrust of their peers and colleagues; and proposes a set of initial principles intended to foster physician-physician trust.
This Viewpoint discusses the importance of reciprocal trust between patients and physicians, identifies reasons physicians may not trust their patients, and proposes ways physicians can communicate their trust directly to patients.
This Viewpoint proposes a guideline-based approach to weight management counseling in primary care, emphasizing the need to avoid stigmatizing overweight and obesity, and the need for physician persistence in offering patients their attention, support, and individualized treatment.
This Viewpoint discusses the lack of nutrition education offered to medical students, despite the important role that physicians can and should play in advising patients on the topic, and proposes ways to integrate meaningful nutrition instruction into all phases of medical training.
In this narrative medicine essay, a palliative care physician with breast cancer talks about the end-of-life conversations she and her husband have, recalling how her priorities have changed through life stages and how she uses her experiences to inform her interactions with her own cancer patients.
This JAMA Guide to Statistics and Methods reviews the use of cost-effectiveness analysis to quantify the tradeoffs in costs, harms, and benefits of new health care interventions compared with existing interventions.
This JAMA Performance Improvement article uses the case of a patient who presented to the emergency department but left after waiting 4 hours without being seen to discuss interdisciplinary improvement efforts for reducing system inefficiencies and improving access to care in emergency departments.
A 65-year-old woman presented with 2 days of throbbing, bilateral temporal headache and bilateral blurred vision, an erythrocyte sedimentation rate (ESR) of 110 mm/h, and total protein of 10.4 g/dL. Results of a temporal artery biopsy showed a normal caliber lumen without infiltrating inflammatory cells. What is the diagnosis, and what would you do next?
This Medical News story examines the controversy over the safety and effectiveness of mesh implants used to treat pelvic organ prolapse and stress urinary incontinence.
This Medical News feature provides highlights of a comprehensive international database that can help clinicians and patients clarify the meaning of BRCA1 and BRCA2 genetic variants.
This Arts and Medicine essay describes the growth of clinical role-play ASMR videos online, reviews what little is known about the ASMR phenomenon, and discusses it in the context of placebo response research.
This JAMA Patient Page describes the symptoms, diagnosis, and treatment of eosinophilic esophagitis.
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