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October 2021 - July 1883




May 7, 2019, Vol 321, No. 17, Pages 1647-1738

In This Issue of JAMA


Abstract Full Text
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JAMA. 2019;321(17):1647-1649. doi:10.1001/jama.2018.15311
Original Investigation

Caring for the Critically Ill Patient

Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest: The PRINCESS Randomized Clinical Trial

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JAMA. 2019;321(17):1677-1685. doi:10.1001/jama.2019.4149

This randomized clinical trial compares the effects of prehospital trans-nasal evaporative intra-arrest cooling vs standard systemic cooling after hospital arrival in the ICU on survival with good neurologic outcome, defined as Cerebral Performance Score of 1-2 at 90 days.

Effect of a Single Aspirin Dose Prior to Fecal Immunochemical Testing on Test Sensitivity for Detecting Advanced Colorectal Neoplasms: A Randomized Clinical Trial

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JAMA. 2019;321(17):1686-1692. doi:10.1001/jama.2019.4755

This randomized clinical trial compares the effect of a single oral dose of aspirin vs placebo prior to fecal immunochemical testing (FIT) on test sensitivity for detecting advanced colorectal neoplasms.

Effect of Aclidinium Bromide on Major Cardiovascular Events and Exacerbations in High-Risk Patients With Chronic Obstructive Pulmonary Disease: The ASCENT-COPD Randomized Clinical Trial

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JAMA. 2019;321(17):1693-1701. doi:10.1001/jama.2019.4973

This randomized clinical trial compares the effects of the long-acting muscarinic antagonist aclidinium bromide vs placebo on major adverse cardiovascular events and chronic obstructive pulmonary disease (COPD) exacerbations in patients with COPD and increased cardiovascular risk.

Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes

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JAMA. 2019;321(17):1702-1715. doi:10.1001/jama.2019.3820

This meta-analysis uses individual patient-level data from participants in 25 pregnancy and birth cohort studies to examine associations between gestational weight gain ranges and risk of adverse maternal and infant outcomes and to estimate optimal gestational weight gain ranges across prepregnancy weight ranges.

Research Letter

Prevalence of Alcoholic Fatty Liver Disease Among Adults in the United States, 2001-2016

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JAMA. 2019;321(17):1723-1725. doi:10.1001/jama.2019.2276

This national survey study uses National Health and Nutrition Examination Survey (NHANES) data to estimate the prevalence of alcoholic fatty liver disease (AFLD) overall and with stage 2 or greater and stage 3 or greater fibrosis among US adults from 2001 to 2016.


Health Policy

The Implications of “Medicare for All” for US Hospitals

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JAMA. 2019;321(17):1661-1662. doi:10.1001/jama.2019.3134

This Viewpoint discusses the interplay between the advancement of a “Medicare-for-all” US health care policy initiative and the current cost margins and management strategies of hospitals, which comprise the largest share of US health care expenditures.

Ensuring Equity and Justice in the Care and Outcomes of Patients With Cancer

Abstract Full Text
JAMA. 2019;321(17):1663-1664. doi:10.1001/jama.2019.4266

In this Viewpoint, Otis Brawley and colleagues review evidence of racial disparities in breast, prostate, and colorectal cancer survival, highlight regional programs that reduced the disparities, and call upon policy makers to institute mandates to equalize quality and access to cancer treatment nationwide.

Closing the Gender Wage Gap and Achieving Professional Equity in Medicine

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JAMA. 2019;321(17):1665-1666. doi:10.1001/jama.2019.4168

This Viewpoint discusses the persistent, widening gender wage gap among physicians and surgeons; describes some of the challenges of assessing wage equity between women and men; and calls for leaders in medicine to address unconscious gender bias, encourage women to enter a wider range of specialties, and increase provision of maternity leave.

Reimagining Health—Flourishing

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JAMA. 2019;321(17):1667-1668. doi:10.1001/jama.2019.3035

This Viewpoint argues that the concept of “flourishing”—a sense of well-being in domains of happiness, mental and physical health, meaning and purpose, character, social relationships, and financial stability—measures health more broadly than existing wellness metrics and should inform clinical and health policy trade-offs and decisions.

A Piece of My Mind

History Taking in the Anatomy Lab

Abstract Full Text
JAMA. 2019;321(17):1669. doi:10.1001/jama.2019.4741

This narrative medicine essay describes the obituary writing program at Georgetown Medical School, a writing workshop developed by the student author with the help of a Washington Post obituary writer, to reveal the lives of the cadavers they worked on, culminating in obituaries read aloud at the end-of-course celebration to thank families for their loved ones’ gift.


US Health Policy—2020 and Beyond: Introducing a New JAMA Series

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JAMA. 2019;321(17):1670-1672. doi:10.1001/jama.2019.3451

Translating Protective Hypothermia During Cardiac Arrest Into Clinical Practice

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JAMA. 2019;321(17):1673-1675. doi:10.1001/jama.2019.4253

Women’s Health: A New JAMA Clinical Insights Series

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JAMA. 2019;321(17):1676. doi:10.1001/jama.2019.3957
JAMA Insights

Women's Health

Treatment of Nonmetastatic Breast Cancer

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JAMA. 2019;321(17):1716-1717. doi:10.1001/jama.2019.3927

This JAMA Insights: Women’s Health review summarizes the current standard of care for the diagnosis and management of nonmetastatic breast cancer by disease subtype and patient characteristics, including surveillance for recurrence after treatment and for long-term adverse treatment effects.

JAMA Clinical Challenge

Irregular Lipomatous Extremity Tumor

Abstract Full Text
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JAMA. 2019;321(17):1718-1719. doi:10.1001/jama.2019.3719

A 71-year-old healthy woman has an enlarging, immobile, painless mass in her right gluteal area, with no neurovascular deficits; computed tomography reveals an 11-cm heterogeneous lipomatous tumor involving the right gluteal musculature. What is the diagnosis and what would you do next?

From The Medical Letter on Drugs and Therapeutics

Cardiovascular Benefits of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes

Abstract Full Text
JAMA. 2019;321(17):1720-1721. doi:10.1001/jama.2019.2702

This Medical Letter review summarizes the cardiovascular benefits and adverse effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors (empagliflozin, canagliflozin) and glucagon-like peptide 1 (GLP-1) receptor agonists (liraglutide, semaglutide) in patients with type 2 diabetes at risk for cardiovascular disease.

Editor's Note

Prepregnancy Body Mass Index, Weight Gain During Pregnancy, and Health Outcomes

Abstract Full Text
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JAMA. 2019;321(17):1715. doi:10.1001/jama.2019.3821
Medical News & Perspectives

High-Fiber Diet Might Protect Against Range of Conditions

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JAMA. 2019;321(17):1653-1655. doi:10.1001/jama.2019.2539

This Medical News story discusses the increasing evidence that foods naturally high in fiber reduce the risks of a host of medical conditions.

Quick Uptakes

How Do Multiple Symptoms Really Affect Older Adults?

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JAMA. 2019;321(17):1655-1656. doi:10.1001/jama.2019.1470

This Medical News article offers highlights from a study describing how the burden of multiple symptoms affects older adults’ functional abilities.

News From the Food and Drug Administration

Efforts to Improve Mammography Highlight Breast Density

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JAMA. 2019;321(17):1659. doi:10.1001/jama.2019.5360

New Device for Patients With Heart Failure

Abstract Full Text
JAMA. 2019;321(17):1659. doi:10.1001/jama.2019.5022

Caution Accompanies New MS Drug

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JAMA. 2019;321(17):1659. doi:10.1001/jama.2019.5361
The JAMA Forum

Doing Health Reform Better: Listening to the Public

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JAMA. 2019;321(17):1656-1657. doi:10.1001/jama.2019.4342
Bench to Bedside

Fever Induces a Molecular Homing Response in Immune Cells During Infection

Abstract Full Text
JAMA. 2019;321(17):1657-1658. doi:10.1001/jama.2019.4475
Poetry and Medicine


Abstract Full Text
JAMA. 2019;321(17):1731. doi:10.1001/jama.2019.1497
JAMA Revisited

To Seek, per Chance to Find

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JAMA. 2019;321(17):1732. doi:10.1001/jama.2018.15319
JAMA Patient Page

Necrotizing Soft Tissue Infections

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JAMA. 2019;321(17):1738. doi:10.1001/jama.2019.2007

This JAMA Patient Page describes the symptoms, diagnosis, and treatment of necrotizing soft tissue infections.

Comment & Response

Prophylactic Hypothermia for Severe Traumatic Brain Injury

Abstract Full Text
JAMA. 2019;321(17):1725. doi:10.1001/jama.2019.1534

Prophylactic Hypothermia for Severe Traumatic Brain Injury—Reply

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JAMA. 2019;321(17):1726. doi:10.1001/jama.2019.1538

Racial Disparities in Low-Risk Prostate Cancer

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JAMA. 2019;321(17):1726-1727. doi:10.1001/jama.2019.2060

Racial Disparities in Low-Risk Prostate Cancer—Reply

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JAMA. 2019;321(17):1727-1728. doi:10.1001/jama.2019.2088

Transparent Disclosure of Conflicts of Interest

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JAMA. 2019;321(17):1728. doi:10.1001/jama.2019.1530

Transparent Disclosure of Conflicts Of Interest—Reply

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JAMA. 2019;321(17):1728-1729. doi:10.1001/jama.2019.1545

Group Purchasing Organizations and Costs

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JAMA. 2019;321(17):1729. doi:10.1001/jama.2019.1099

Group Purchasing Organizations and Costs—Reply

Abstract Full Text
JAMA. 2019;321(17):1729-1730. doi:10.1001/jama.2019.1103
JAMA Masthead


Abstract Full Text
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JAMA. 2019;321(17):1651-1652. doi:10.1001/jama.2018.15312