This randomized clinical trial compares the effects of prehospital trans-nasal evaporative intra-arrest cooling vs standard systemic cooling after hospital arrival in the ICU on survival with good neurologic outcome, defined as Cerebral Performance Score of 1-2 at 90 days.
This randomized clinical trial compares the effect of a single oral dose of aspirin vs placebo prior to fecal immunochemical testing (FIT) on test sensitivity for detecting advanced colorectal neoplasms.
This randomized clinical trial compares the effects of the long-acting muscarinic antagonist aclidinium bromide vs placebo on major adverse cardiovascular events and chronic obstructive pulmonary disease (COPD) exacerbations in patients with COPD and increased cardiovascular risk.
This meta-analysis uses individual patient-level data from participants in 25 pregnancy and birth cohort studies to examine associations between gestational weight gain ranges and risk of adverse maternal and infant outcomes and to estimate optimal gestational weight gain ranges across prepregnancy weight ranges.
This national survey study uses National Health and Nutrition Examination Survey (NHANES) data to estimate the prevalence of alcoholic fatty liver disease (AFLD) overall and with stage 2 or greater and stage 3 or greater fibrosis among US adults from 2001 to 2016.
This Viewpoint discusses the interplay between the advancement of a “Medicare-for-all” US health care policy initiative and the current cost margins and management strategies of hospitals, which comprise the largest share of US health care expenditures.
In this Viewpoint, Otis Brawley and colleagues review evidence of racial disparities in breast, prostate, and colorectal cancer survival, highlight regional programs that reduced the disparities, and call upon policy makers to institute mandates to equalize quality and access to cancer treatment nationwide.
This Viewpoint discusses the persistent, widening gender wage gap among physicians and surgeons; describes some of the challenges of assessing wage equity between women and men; and calls for leaders in medicine to address unconscious gender bias, encourage women to enter a wider range of specialties, and increase provision of maternity leave.
This Viewpoint argues that the concept of “flourishing”—a sense of well-being in domains of happiness, mental and physical health, meaning and purpose, character, social relationships, and financial stability—measures health more broadly than existing wellness metrics and should inform clinical and health policy trade-offs and decisions.
This narrative medicine essay describes the obituary writing program at Georgetown Medical School, a writing workshop developed by the student author with the help of a Washington Post obituary writer, to reveal the lives of the cadavers they worked on, culminating in obituaries read aloud at the end-of-course celebration to thank families for their loved ones’ gift.
This JAMA Insights: Women’s Health review summarizes the current standard of care for the diagnosis and management of nonmetastatic breast cancer by disease subtype and patient characteristics, including surveillance for recurrence after treatment and for long-term adverse treatment effects.
A 71-year-old healthy woman has an enlarging, immobile, painless mass in her right gluteal area, with no neurovascular deficits; computed tomography reveals an 11-cm heterogeneous lipomatous tumor involving the right gluteal musculature. What is the diagnosis and what would you do next?
This Medical Letter review summarizes the cardiovascular benefits and adverse effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors (empagliflozin, canagliflozin) and glucagon-like peptide 1 (GLP-1) receptor agonists (liraglutide, semaglutide) in patients with type 2 diabetes at risk for cardiovascular disease.
This Medical News story discusses the increasing evidence that foods naturally high in fiber reduce the risks of a host of medical conditions.
This Medical News article offers highlights from a study describing how the burden of multiple symptoms affects older adults’ functional abilities.
This JAMA Patient Page describes the symptoms, diagnosis, and treatment of necrotizing soft tissue infections.
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