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November 2021 - July 1883

Decade

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Issue

January 15, 2019, Vol 321, No. 2, Pages 119-216

In This Issue of JAMA

Highlights

Abstract Full Text
free access has audio
JAMA. 2019;321(2):119-121. doi:10.1001/jama.2018.15146
Original Investigation

Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis

Abstract Full Text
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JAMA. 2019;321(2):175-187. doi:10.1001/jama.2018.20588

In this cohort study, initial treatment of patients with relapsing-remitting multiple sclerosis (MS) with disease-modifying therapies (fingolimod, natalizumab, or alemtuzumab) was associated with a lower risk of conversion to secondary progressive MS compared with interferon beta or glatiramer acetate therapy.

Preliminary Communication

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2019;321(2):156-164. doi:10.1001/jama.2018.20046

This randomized clinical trial compares the ability of anaerobically prepared pooled donor vs autologous fecal microbiota transplantation to induce remission in patients with ulcerative colitis (UC).

Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2019;321(2):165-174. doi:10.1001/jama.2018.18743

In this randomized trial, nonmyeloablative hematopoietic stem cell transplantation (HSCT) resulted in longer time to disease progression among patients with relapsing-remitting multiple sclerosis compared with continued disease-modifying therapy.

Research Letter

Serum Creatinine Levels Before, During, and After Pregnancy

Abstract Full Text
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JAMA. 2019;321(2):205-207. doi:10.1001/jama.2018.17948

This study uses Canadian administrative health databases to estimate gestational age–specific serum creatinine levels before, during, and after pregnancy among women without antecedent kidney disease.

Viewpoint

Rethinking How Antibiotics Are Prescribed: Incorporating the 4 Moments of Antibiotic Decision Making Into Clinical Practice

Abstract Full Text
JAMA. 2019;321(2):139-140. doi:10.1001/jama.2018.19509

This Viewpoint summarizes recommendations from the Agency for Healthcare Research and Quality for improving antibiotic use and safety that encourages clinicians to ask if antibiotics are necessary, and to use testing and deliberate judgment to decide which ones, for how long, and if coverage can be narrowed or the drugs stopped altogether.

Physicians’ Voices on Gun Violence and Other Important Public Health Issues

Abstract Full Text
JAMA. 2019;321(2):141-142. doi:10.1001/jama.2018.20754

In this Viewpoint, Sandro Galea acknowledges reasons physicians have traditionally been hesitant to speak out publicly on matters of politics and public health, and reviews how shifting roles and means of communication are forcing practitioners to reconsider that hesitancy and engage in controversies of public health concern, such as gun violence.

Free Medical School Tuition: Will It Accomplish Its Goals?

Abstract Full Text
JAMA. 2019;321(2):143-144. doi:10.1001/jama.2018.19457

This Viewpoint discusses free or reduced tuition programs for medical students and the implications for diversifying the health care workforce, filling shortages in primary care specialties, improving patient access, closing the health disparities gap, and improving population health.

Challenges of Non–Intention-to-Treat Analyses

Abstract Full Text
JAMA. 2019;321(2):145-146. doi:10.1001/jama.2018.19192

This Viewpoint reviews the rationale for intention-to-treat (ITT) analyses of randomized trials, explains how commonly used alternatives reintroduce confounding that randomization is intended to eliminate, and emphasizes that even an ITT analysis is no substitute for informed scientific and clinical judgement when interpreting trial results.

Medicare’s Approach to Paying for Services That Promote Coordinated Care

Abstract Full Text
JAMA. 2019;321(2):147-148. doi:10.1001/jama.2018.19315

This Viewpoint discusses new fee-for-service billing codes introduced by CMS for reimbursement of virtual care including e-consults, remote physiologic monitoring, and video and image review, and proposes strategies to incentivize the activities to promote coordinated care.

A Piece of My Mind

The Unicorn

Abstract Full Text
JAMA. 2019;321(2):149-150. doi:10.1001/jama.2018.21048

In this narrative medicine essay, a black physician relates the surprise and joy a black patient has when a he meets a black doctor in the examination room and comments on the need for medical schools to step up recruitment and training of a diverse physician workforce.

Editorial

Manipulating the Microbiome With Fecal Transplantation to Treat Ulcerative Colitis

Abstract Full Text
JAMA. 2019;321(2):151-152. doi:10.1001/jama.2018.20397

Stem Cell Transplantation to Treat Multiple Sclerosis

Abstract Full Text
JAMA. 2019;321(2):153-155. doi:10.1001/jama.2018.20777
Review

Evaluation and Management of Penicillin Allergy: A Review

Abstract Full Text
has active quiz has multimedia has audio
JAMA. 2019;321(2):188-199. doi:10.1001/jama.2018.19283

This narrative review summarizes the epidemiology of penicillin allergy and the clinical consequences of misattributing adverse drug events to β-lactam allergy, including development of antimicrobial resistance and adverse events associated with alternative antibiotics, and proposes an algorithm to facilitate evaluation of true penicillin allergy.

JAMA Clinical Guidelines Synopsis

Management of Posttraumatic Stress Disorder

Abstract Full Text
JAMA. 2019;321(2):200-201. doi:10.1001/jama.2018.19290

This JAMA Clinical Guidelines Synopsis summarizes the 2017 clinical practice guidance from the US Department of Veterans Affairs/US Department of Defense on management of posttraumatic stress disorder and acute stress disorder.

JAMA Diagnostic Test Interpretation

Immunoglobulin G4 Levels

Abstract Full Text
has active quiz
JAMA. 2019;321(2):202-203. doi:10.1001/jama.2018.16665

A 67-year-old man with type 2 diabetes, unintentional weight loss, and increasing fasting blood glucose levels showed diffuse enlargement of the pancreas with peripheral hypoenhancement but no discrete mass on CT scan and soft tissue surrounding the abdominal arteries and left ureter causing hydronephrosis. Testing showed no pancreatic malignancy, no abnormal findings on colonoscopy, and lab results showed elevated IgG4. How would you interpret the test results?

Medical News & Perspectives

Immunotherapy 2.0: Improving the Response to Checkpoint Inhibitors

Abstract Full Text
JAMA. 2019;321(2):131-133. doi:10.1001/jama.2018.18306

This Medical News article discusses the evolution of checkpoint inhibitor immunotherapies to improve efficacy and predict which patients will benefit the most.

Physicians Are Steering the Conversation About Gun Violence

Abstract Full Text
has audio
JAMA. 2019;321(2):133-135. doi:10.1001/jama.2018.20385

This Medical News story is an interview with Megan Ranney, MD, MPH, one of the leading voices in the “This Is Our Lane” movement, which discusses the role of physicians and other health-care professionals in addressing firearm violence as a public health issue.

The JAMA Forum

Medicaid as a Safeguard for Financial Health

Abstract Full Text
free access
JAMA. 2019;321(2):135-136. doi:10.1001/jama.2018.20427
News From the Centers for Disease Control and Prevention

Tickborne Diseases Increasing

Abstract Full Text
JAMA. 2019;321(2):138. doi:10.1001/jama.2018.20464

Youth e-Cigarette Use

Abstract Full Text
JAMA. 2019;321(2):138. doi:10.1001/jama.2018.20655
Biotech Innovations

IDWeek Fosters Innovation in Infectious Disease Care

Abstract Full Text
has audio
JAMA. 2019;321(2):137. doi:10.1001/jama.2018.20548
Poetry and Medicine

At the Line in the Sand, On the Bridge in the Rain, On the Borders That Do Not Exist

Abstract Full Text
JAMA. 2019;321(2):210. doi:10.1001/jama.2018.11164
JAMA Revisited

“Aspirin”—A Common Name

Abstract Full Text
JAMA. 2019;321(2):211. doi:10.1001/jama.2018.15154
JAMA Patient Page

Am I Allergic to Penicillin?

Abstract Full Text
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JAMA. 2019;321(2):216. doi:10.1001/jama.2018.20470

This JAMA Patient Page describes evaluation for and diagnosis of penicillin allergy.

Comment & Response

Advantages and Disadvantages of Direct Primary Care

Abstract Full Text
JAMA. 2019;321(2):207. doi:10.1001/jama.2018.18143

Advantages and Disadvantages of Direct Primary Care

Abstract Full Text
JAMA. 2019;321(2):207-208. doi:10.1001/jama.2018.18147

Advantages and Disadvantages of Direct Primary Care—Reply

Abstract Full Text
JAMA. 2019;321(2):208. doi:10.1001/jama.2018.18154

Clinical Practice Guidelines and the Need for Systematic Reviews

Abstract Full Text
JAMA. 2019;321(2):208-209. doi:10.1001/jama.2018.18790

Clinical Practice Guidelines and the Need for Systematic Reviews—Reply

Abstract Full Text
JAMA. 2019;321(2):209. doi:10.1001/jama.2018.18795
Correction

Data Errors in Figure

Abstract Full Text
free access
JAMA. 2019;321(2):209. doi:10.1001/jama.2018.21022
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2019;321(2):123-124. doi:10.1001/jama.2018.15147
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