This randomized noninferiority trial compares the effect of laparoscopic distal gastrectomy with open distal gastrectomy for locally advanced gastric cancer.
This randomized trial compares the effect of recombinant human soluble thrombomodulin vs placebo in patients with sepsis-associated coagulopathy on 28-day all-cause mortality.
In this study, Sepsis-3 investigators use electronic health record and trial data from patients with sepsis within 6 hours of hospital presentation to define clinical phenotypes that correlate with host-response patterns, sepsis biomarkers, mortality, and treatment effects.
This study describes point-of-sale prices for orally administered anticancer drugs offered through Medicare Part D and out-of-pocket changes in spending as a result of decreasing coinsurance and price changes between 2010 and 2019.
This study compared monetary penalties and rewards among safety net vs non–safety net hospitals under Medicare’s Comprehensive Care for Joint Replacement (CJR) model, a bundled payment plan for hip and knee replacements intended to incentivize health care quality and savings, in 2016 and 2017.
This Viewpoint describes the neurological disorder known as psychogenic nonepileptic attacks (PNEA)—including the symptoms, appropriate diagnostic testing, and treatment with cognitive behavioral therapy—and how it can be distinguished from epilepsy to avoid treating patients with PNEA with potentially harmful epileptic medications or surgery.
This Viewpoint discusses public distrust of vaccinations fueled by false information on vaccine safety spread through social media, and discusses the ways in which physicians, public health authorities, states, and social media platforms can help curb the spread of misinformation and instead provide information on the safety and importance of vaccines.
This Viewpoint discusses the increasing use of robotic-assisted surgery and the issues, including potential harm, surgeon credentialing, and transparency in informed patient consent, that should be considered by payers, health care organizations, and surgeons to ensure that safeguards remain in place until stronger evidence for or against the use of this technology is available.
In this Viewpoint, authors from the International Center for Diarrheal Disease Research in Bangladesh discuss rapid urbanization in low- and middle-income countries and the associated challenges of meeting the basic health care needs of growing urban slum populations.
This Viewpoint discusses the realities that keep integrated health systems (IHSs) from providing a full range of patient care services from primary through quaternary care, and outlines strategic considerations important for IHS stakeholders to account for if they are to effectively serve their patient communities in a shifting technological and regulatory environment.
In this narrative medicine essay, the tension stirred when a barista urges a homeless man out of an upscale coffee shop reminds an emergency department physician to consider the daily or weekly life cycles of homeless men and women who seek shelter and care in emergency departments.
This JAMA Clinical Insights review summarizes recent cervical cancer screening guidelines from the USPSTF, ACOG, and ACS, and proposes an algorithm for responding to abnormal screening results in women at average risk in age group 25 to 29 and older than 30.
This JAMA Insights Clinical Update reviews use of active ultrasonography surveillance of patients with thyroid cancer as a way to postpone or avoid thyroidectomy in patients with lower-risk tumors for whom surgery is more likely to be harmful than beneficial.
This JAMA Clinical Guidelines Synopsis summarizes the 2017 US Multi-Society Task Force on Colorectal Cancer recommendations for colorectal cancer screening.
This Medical News article is a discussion with the author of a recent study in JAMA that looked at the association of dietary cholesterol with cardiovascular disease.
This Quick Uptakes article explains that some inactive ingredients in medications can cause adverse events.
This JAMA Patient Page describes use of enteral nutrition for short-term and long-term health conditions.
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