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May 2022 - July 1883




June 4, 2019, Vol 321, No. 21, Pages 2045-2142

In This Issue of JAMA


Abstract Full Text
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JAMA. 2019;321(21):2045-2047. doi:10.1001/jama.2018.15355
Original Investigation

Effect of Neladenoson Bialanate on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial

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JAMA. 2019;321(21):2101-2112. doi:10.1001/jama.2019.6717

This dose-ranging phase 2b randomized trial compares the effects of neladenoson, a partial adenosine A1 receptor agonist, vs placebo on exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF).

Association of Stroke Among Adults Aged 18 to 49 Years With Long-term Mortality

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JAMA. 2019;321(21):2113-2123. doi:10.1001/jama.2019.6560

This cohort study uses Dutch registry and population data to estimate associations between incident stroke occurring between ages 18 and 49 years and short- and long-term all-cause mortality stratified by age, sex, and stroke subtype.

Preliminary Communication

Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2019;321(21):2082-2091. doi:10.1001/jama.2019.5586

This randomized clinical trial recruited healthy volunteers to assess whether the active ingredients of commercially available sunscreen products (avobenzone, oxybenzone, octocrylene, and ecamsule) are absorbed into systemic circulation under maximal use conditions.

Effect of a Home-Based Exercise Program on Subsequent Falls Among Community-Dwelling High-Risk Older Adults After a Fall: A Randomized Clinical Trial

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JAMA. 2019;321(21):2092-2100. doi:10.1001/jama.2019.5795

This randomized trial compares the effect of geriatrician-delivered fall prevention care with vs without a physical therapist–delivered home-based strength and balance retraining exercise program on number of subsequent falls in older adults who were referred to a fall prevention clinic after a previous fall.

Research Letter

Prevalence and Payments for Traumatic Injury Compared With Common Acute Diseases by Episode of Care in Medicare Beneficiaries, 2008-2014

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JAMA. 2019;321(21):2129-2131. doi:10.1001/jama.2019.1146

This study uses Medicare Parts A and B claims data to compare hospitalizations for and spending on traumatic injury vs heart failure, pneumonia, stroke, and acute myocardial infarction in older adults between 2008 and 2014.

Mortality From Falls Among US Adults Aged 75 Years or Older, 2000-2016

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JAMA. 2019;321(21):2131-2133. doi:10.1001/jama.2019.4185

This study uses National Vital Statistics System data from 2000-2016 to characterize trends in mortality from falls in the US population aged 75 years or older.


The Importance of Predefined Rules and Prespecified Statistical Analyses: Do Not Abandon Significance

Abstract Full Text
JAMA. 2019;321(21):2067-2068. doi:10.1001/jama.2019.4582

In this Viewpoint, John Ioannidis argues against abandoning the notion and language of statistical significance, which has been proposed as a means to diminish oversimplistic interpretations of clinical research. A significance filter in some form is essential for distinguishing signal from noise, he writes, and emphasizes that predefined study design choices, prespecified statistical analyses, transparent and documented deviations from either, and improvement in researchers’ statistical numeracy can minimize overly subjective interpretations of whatever significance measure is used.

Health Policy

Does Employment-Based Insurance Make the US Medical Care System Unfair and Inefficient?

Abstract Full Text
JAMA. 2019;321(21):2069-2070. doi:10.1001/jama.2019.4812

In this Viewpoint, Victor Fuchs reviews the evolution of the US employer-based health insurance toward a system favoring higher-income individuals, and proposes reforms in health care financing and in accessibility of lower-cost care as a way to make the system more fair and efficient.

Medication-Based Treatment to Address Opioid Use Disorder

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JAMA. 2019;321(21):2071-2072. doi:10.1001/jama.2019.5523

In this Viewpoint the president of NAM and the former CEO of AAAS emphasize the importance of approaching opioid use disorder (OUD) as a chronic brain disease and of using evidence-based FDA-approved interventions to manage it, urging clinicians to overcome any personal biases that might interfere with provision of evidence-based care to help patients with OUD recover from their addiction.

Global Health Spending and Development Assistance for Health

Abstract Full Text
JAMA. 2019;321(21):2073-2074. doi:10.1001/jama.2019.3687

This Viewpoint reviews the global health role of development assistance for health (DAH) and financial or in-kind assistance provided by western countries via international development agencies and foundations to low- and middle-income countries (LMICs), and proposes best practices to ensure that DAH continues to be a reliable source of support for LMIC health systems and assists them to develop pandemic preparedness.

A Piece of My Mind

Going Home

Abstract Full Text
JAMA. 2019;321(21):2075-2076. doi:10.1001/jama.2019.6924

In this narrative medicine essay a physician beginning her internship recalls what she learned from her grandfather in his life as a surgical oncologist and in his final illness, recognizing that the essence of doctoring lies in being present with the patient and offering them companionship, encouragement, and a sense of being known.


Filling in the Evidence About Sunscreen

Abstract Full Text
JAMA. 2019;321(21):2077-2079. doi:10.1001/jama.2019.5528

Falls in Older Adults: Prevention, Mortality, and Costs

Abstract Full Text
JAMA. 2019;321(21):2080-2081. doi:10.1001/jama.2019.6569
JAMA Guide to Statistics and Methods

Using Instrumental Variables to Address Bias From Unobserved Confounders

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JAMA. 2019;321(21):2124-2125. doi:10.1001/jama.2019.5646

This JAMA Guide to Statistics and Methods reviews the use of instrumental variable analysis in observational and randomized studies and how, under specific assumptions, they can provide unbiased estimates of treatment effects even if unobserved confounding exists.

JAMA Insights

Women's Health

Abnormal Uterine Bleeding in Reproductive-Age Women

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JAMA. 2019;321(21):2126-2127. doi:10.1001/jama.2019.5248

This JAMA Clinical Insights article summarizes the diagnosis and treatment of abnormal uterine bleeding in reproductive-age women, distinguishing between heavy menstrual bleeding, ovulatory dysfunction, and other patterns and causes.

Medical News & Perspectives

Limits on Opioid Prescribing Leave Patients With Chronic Pain Vulnerable

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JAMA. 2019;321(21):2059-2062. doi:10.1001/jama.2019.5188

This Medical News story discusses the impact of opioid prescribing restrictions on patients with chronic pain.

Quick Uptakes

Sleeping In Doesn’t Mitigate Metabolic Changes Linked to Sleep Deficit

Abstract Full Text
JAMA. 2019;321(21):2062-2063. doi:10.1001/jama.2019.4701

This Medical News story discusses a recent study that suggests sleeping late on the weekend cannot mitigate the metabolic dysregulation associated with recurrent insufficient sleep during the week.

News From the Food and Drug Administration

Dengue Vaccine Gets the Nod

Abstract Full Text
JAMA. 2019;321(21):2066. doi:10.1001/jama.2019.6886

New Warnings for Insomnia Drugs

Abstract Full Text
JAMA. 2019;321(21):2066. doi:10.1001/jama.2019.6889

Trigeminal Nerve Stimulator for ADHD

Abstract Full Text
JAMA. 2019;321(21):2066. doi:10.1001/jama.2019.6992
The JAMA Forum

How an Expanded Vision of Managed Care Organizations Could Tackle Inequities

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JAMA. 2019;321(21):2063-2064. doi:10.1001/jama.2019.6494
Bench to Bedside

Noninvasive Ultrasound May Help Treat Inflammation and Other Conditions

Abstract Full Text
JAMA. 2019;321(21):2064-2065. doi:10.1001/jama.2019.6653
Poetry and Medicine

Trypan Blue

Abstract Full Text
JAMA. 2019;321(21):2137. doi:10.1001/jama.2019.2489
JAMA Revisited

Deficient Instruction in Biology in High Schools

Abstract Full Text
JAMA. 2019;321(21):2138. doi:10.1001/jama.2018.15363
JAMA Patient Page

Parenteral Nutrition

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JAMA. 2019;321(21):2142. doi:10.1001/jama.2019.4410

This JAMA Patient Page describes the use of parenteral nutrition for short-term and long-term health conditions.

Comment & Response

Business Strategies to Promote Health

Abstract Full Text
JAMA. 2019;321(21):2133-2134. doi:10.1001/jama.2019.2799

Business Strategies to Promote Health—Reply

Abstract Full Text
JAMA. 2019;321(21):2134. doi:10.1001/jama.2019.2803

Alternatives to Intention-to-Treat Analyses

Abstract Full Text
JAMA. 2019;321(21):2134-2135. doi:10.1001/jama.2019.3092

Alternatives to Intention-to-Treat Analyses—Reply

Abstract Full Text
JAMA. 2019;321(21):2135. doi:10.1001/jama.2019.3096

Estimating Renal Function in Pregnancy

Abstract Full Text
JAMA. 2019;321(21):2136. doi:10.1001/jama.2019.3614

Estimating Renal Function in Pregnancy—Reply

Abstract Full Text
JAMA. 2019;321(21):2136. doi:10.1001/jama.2019.3618
JAMA Masthead


Abstract Full Text
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JAMA. 2019;321(21):2049-2050. doi:10.1001/jama.2018.15356