This dose-ranging phase 2b randomized trial compares the effects of neladenoson, a partial adenosine A1 receptor agonist, vs placebo on exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF).
This cohort study uses Dutch registry and population data to estimate associations between incident stroke occurring between ages 18 and 49 years and short- and long-term all-cause mortality stratified by age, sex, and stroke subtype.
This randomized clinical trial recruited healthy volunteers to assess whether the active ingredients of commercially available sunscreen products (avobenzone, oxybenzone, octocrylene, and ecamsule) are absorbed into systemic circulation under maximal use conditions.
This randomized trial compares the effect of geriatrician-delivered fall prevention care with vs without a physical therapist–delivered home-based strength and balance retraining exercise program on number of subsequent falls in older adults who were referred to a fall prevention clinic after a previous fall.
This study uses Medicare Parts A and B claims data to compare hospitalizations for and spending on traumatic injury vs heart failure, pneumonia, stroke, and acute myocardial infarction in older adults between 2008 and 2014.
This study uses National Vital Statistics System data from 2000-2016 to characterize trends in mortality from falls in the US population aged 75 years or older.
In this Viewpoint, John Ioannidis argues against abandoning the notion and language of statistical significance, which has been proposed as a means to diminish oversimplistic interpretations of clinical research. A significance filter in some form is essential for distinguishing signal from noise, he writes, and emphasizes that predefined study design choices, prespecified statistical analyses, transparent and documented deviations from either, and improvement in researchers’ statistical numeracy can minimize overly subjective interpretations of whatever significance measure is used.
In this Viewpoint, Victor Fuchs reviews the evolution of the US employer-based health insurance toward a system favoring higher-income individuals, and proposes reforms in health care financing and in accessibility of lower-cost care as a way to make the system more fair and efficient.
In this Viewpoint the president of NAM and the former CEO of AAAS emphasize the importance of approaching opioid use disorder (OUD) as a chronic brain disease and of using evidence-based FDA-approved interventions to manage it, urging clinicians to overcome any personal biases that might interfere with provision of evidence-based care to help patients with OUD recover from their addiction.
This Viewpoint reviews the global health role of development assistance for health (DAH) and financial or in-kind assistance provided by western countries via international development agencies and foundations to low- and middle-income countries (LMICs), and proposes best practices to ensure that DAH continues to be a reliable source of support for LMIC health systems and assists them to develop pandemic preparedness.
In this narrative medicine essay a physician beginning her internship recalls what she learned from her grandfather in his life as a surgical oncologist and in his final illness, recognizing that the essence of doctoring lies in being present with the patient and offering them companionship, encouragement, and a sense of being known.
This JAMA Guide to Statistics and Methods reviews the use of instrumental variable analysis in observational and randomized studies and how, under specific assumptions, they can provide unbiased estimates of treatment effects even if unobserved confounding exists.
This JAMA Clinical Insights article summarizes the diagnosis and treatment of abnormal uterine bleeding in reproductive-age women, distinguishing between heavy menstrual bleeding, ovulatory dysfunction, and other patterns and causes.
This Medical News story discusses the impact of opioid prescribing restrictions on patients with chronic pain.
This Medical News story discusses a recent study that suggests sleeping late on the weekend cannot mitigate the metabolic dysregulation associated with recurrent insufficient sleep during the week.
This JAMA Patient Page describes the use of parenteral nutrition for short-term and long-term health conditions.
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