This randomized trial compares the effect of 30-minute pressure support vs 2-hour T-piece ventilation strategies in spontaneous breathing trials on rate of successful extubation among patients who had been receiving mechanical ventilation for at least 24 hours.
This study examines the association of blood donor sex or previous pregnancy with mortality of transfusion recipients using data from 3 large databases in the United States and Scandinavia.
This registry-based cohort study compared mortality and stroke rates among patients with bicuspid and tricuspid aortic stenosis who had undergone TAVR to determine whether advances in technology and in valve devices improved outcomes for patients with bicuspid aortic anatomy.
This study uses US National Center for Health Statistics data to describe trends in mortality due to aortic stenosis between 2008 and 2017, when use of transcatheter aortic valve replacement (TAVR) in older adults was becoming more common.
Following CMS’ 2018 expansion of supplemental benefits available to HMO and PPO Medicare Advantage enrollees, this study assesses enrollee adoption by type of benefit (eg, caregiver support, in-home personal care, palliative nursing, and social work) and specific plan characteristics in the first year.
This 2019 Recommendation Statement from the US Preventive Services Task Force recommends offering preexposure prophylaxis (PrEP) with effective antiretroviral therapy to persons at high risk of HIV acquisition (A recommendation).
This systematic review to support the 2019 US Preventive Services Task Force guideline on preexposure prophylaxis (PrEP) for the prevention of HIV infection summarizes published evidence on the benefits and harms of preexposure antiretroviral therapy in adults without preexisting HIV infection.
This Viewpoint discusses the importance of trust between physician teachers and their students and trainees, proposing that the trust learned in early educational experiences is a foundation and model for physicians’ career-long trusting relationships with institutions, colleagues, patients, and the public.
This Viewpoint discusses how proliferation of health misinformation to the public undermines trust in science and medicine, and proposes ways the medical community and media might work together to make medical professionals better producers and consumers of accurate health information and to make the news media better at story curation and communication of uncertainty.
This Viewpoint discusses common challenges faced by dual-physician couples and proposes institutional and individual strategies to improve work-life balance.
This Viewpoint uses the commercial rise of MedMen, a US company that operates licensed cannabis facilities and uses youth-oriented media campaigns to advance unproven health claims for marijuana, to highlight the health risks for young people and to argue for evidence-based regulation of marijuana marketing and sales.
In this narrative medicine essay, a medical school dean talks about the reticence most women feel when considering leadership roles and urges women to work out of their comfort zones, seize diverse opportunities, and step into leadership roles.
This JAMA Insights Clinical Update reviews approaches to fracture prevention in older adults, including estimating fracture risk and life expectancy, selecting and managing appropriate medications, and understanding nonpharmacologic strategies.
This Medical Letter review provides a drug table comparing the 6 classes of drugs (bisphosphonates, anti-RANK ligand antibody, parathyroid hormone receptor agonists, selective estrogen receptor modulator, conjugated estrogens/selective estrogen receptor modulator, and calcitonin) used for the treatment of postmenopausal osteoporosis.
This Medical News article discusses trimethylamine N-oxide, or TMAO, a dietary metabolite that’s increasingly associated with cardiovascular disease.
This Medical News article discusses a recent meta-analysis comparing high-intensity interval training, sprint interval training, and moderate-intensity continuous training for fat loss.
This JAMA Patient Page describes the US Preventive Services Task Force’s recent recommendations on prevention of HIV infection with preexposure prophylaxis (PrEP).
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