This randomized trial compares the effects of 1 month of dual antiplatelet therapy (DAPT) followed by clopidogrel monotherapy vs 12 months of DAPT with aspirin and clopidogrel on cardiovascular and bleeding events in patients in Japan who underwent percutaneous coronary intervention (PCI).
This randomized noninferiority trial compares the effect of P2Y12 inhibitor monotherapy vs dual antiplatelet therapy (DAPT) on cardiac and cerebrovascular events in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents.
This study used harmonized and pooled data from 4 US general population–based cohorts to determine the discriminative accuracy of various FEV1:FVC fixed thresholds for predicting COPD-related hospitalization and mortality.
This study describes the credentials and scope of training of physician and nonphysician practitioners working for US companies marketing unproven stem cell procedures.
This cohort study investigates the association between reducing the number of opioid tablets prescribed after anterior cruciate ligament (ACL) reconstruction and postoperative opioid consumption and between preoperative opioid use education about nonopioid pain strategies and duration and quantity of opioid use.
In this Viewpoint, Woolhandler and Himmelstein review the potential benefits of single-payer health care reform, including savings on administrative costs and lower drug prices, and argue against partial solutions that might expand coverage without reducing costs and waste.
This Viewpoint discusses recent evidence documenting benefits of nonpharmacological and drug therapies for major depressive disorder including exercise, Mediterranean diet and structured dietary support, ketamine and esketamine, brexanolone, and psilocybin.
This Viewpoint reviews the recent growth and potential benefits and harms of hybrid models of genetic testing, in which testing services retain the low costs of direct-to-consumer testing and send results to patients but clinicians order the tests and also receive results that they can interpret for patients.
This Viewpoint charts the rise in publications describing risk prediction tools, such as the FRAX, CHADS2, and SOFA scores, and discusses the implications of using algorithms for clinical decisions in the absence of evidence about the effects of the tools on patient care and outcomes.
In this narrative medicine essay, a physician at Boston’s Health Care for the Homeless program describes the experience of responding to frequent injection drug overdoses in the clinic’s restrooms, sees the phenomenon as a result of society’s abandonment of substance users, and argues for clearner, safer spaces where people can use drugs and be connected to others for help.
This Rational Clinical Examination systematic review summarizes the accuracy of the clinical examination and electrocardiogram for distinguishing patients with vs without cardiac causes of syncope.
This JAMA Insights Clinical Update reviews the use of hormonal therapy to manage menopausal vasomotor symptoms and proposes an algorithm for deciding if therapy should be initiated or continued based on a woman’s age, duration since onset of menopause, and risk factors for adverse outcomes.
A 61-year-old man with 1 day of dyspnea and weakness was febrile (38.4°C), hypotensive, tachycardic, diaphoretic, and had poor dentition, a soft S1, and basilar bilateral crackles on examination and aortic regurgitation on transesophageal echocardiography. What is the diagnosis and what would you do next?
This Medical News article describes research proposals the US military is weighing to evaluate sufentanil sublingual tablets, an opioid that gained a controversial FDA approval last year, for battlefield use.
This Medical News article discusses the recent discovery of a gene variant strongly associated with menthol cigarette use.
This JAMA Patient Page describes sigmoid volvulus, its symptoms, and its treatment.
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