This randomized clinical trial compares the effect of a magnetic resonance imaging (MRI)–guided vs a conventional clinical treat-to-remission-target strategy on improving disease activity scores and radiographic progression in patients with rheumatoid arthritis (RA) in clinical remission.
This pragmatic randomized trial compares the effects of EEG-guided anesthetic administration vs usual anesthetic care on incident postoperative delirium among older adults undergoing major surgery.
This population-based cohort study compares standardized reading and mathematics test scores of Danish public schoolchildren with vs without type 1 diabetes to assess the association between diabetes and school performance.
This before-after study examines the association between value-based incentive programs that link financial rewards and penalties to hospital performance on quality indicators and catheter-associated urinary tract infection outcomes in intensive care units (ICUs).
In this Viewpoint, directors at the National Cancer Institute (NCI) review reforms to the NCI clinical trials program, including use of historical controls and aggregating data from existing trials to improve trial efficiency, focusing on rare cancers that industry may overlook, enrolling patients based on molecular alterations instead of disease type, and establishing research facilities in underserved communities.
This Viewpoint discusses the increasing proportion of US surgeons 55 years or older and surgical competence issues related to aging, highlights efforts to assess competence and balance patient safety with maintenance of an effective workforce, and maintains that assessment of surgical competence should be based on functional age and abilities rather than age.
In this Viewpoint, Fauci and colleagues from NIAID review the evidence underlying the 2016 Prevention Access Campaign’s “Undetectable = Untransmittable (U = U)” HIV public health initiative, arguing that the science now supports elimination of the stigma associated with HIV infection.
This Viewpoint discusses the bias experts can introduce to pharmacy and therapeutics committees tasked with evaluating the value of adding new drugs to practice formularies and proposes strategies to reduce bias including anonymous voting; allowing members time for thoughtful review; and training members in study design, critical appraisal, and cost-benefit analysis.
In this narrative medicine essay, a researcher diagnosed with degenerative retinal disease discusses the challenge of being a scientist with a disability and describes how she worked through institutional barriers, depression, and fear with help from peers and mentors to bring insights and energy to a career focusing on vision loss in patients.
This Rational Clinical Examination systematic review characterizes the accuracy of clinical features and bedside tests for predicting difficult endotracheal intubation.
This JAMA Performance Improvement article uses the case of a patient with end-stage renal disease admitted for septic shock, peritonitis, and calciphylaxis who erroneously underwent tunneled central catheter placement after he elected to pursue only hospice care to discuss unintended errors introduced by computerized order entry and opportunities for health information technology system improvements.
This Medical Letter review summarizes doses and formulations of Imvexxy, an estradiol softgel vaginal insert that was recently approved to treat moderate to severe dyspareunia due to vulvovaginal atrophy in postmenopausal women.
This Medical News article is an interview with the coauthor of a new policy statement on corporal punishment for children.
In this Medical News & Perspectives article, researchers discuss insects’ potential as nutrition sources that put less stress on the environment than traditional livestock.
This Arts and Medicine essay reviews The Darker the Night, the Brighter the Stars: A Neuropsychologist’s Odyssey, a book of essays, case studies, philosophy, history, and magical realism by Oxford-trained neuropsychologist Paul Broks that explores ideas about the brain, consciousness, and sense of self.
This JAMA Patient Page describes genital warts and their cause, risk factors, treatment, and prevention.
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