This randomized clinical trial compares the effect of treating adults with hypertension to a systolic blood pressure (SBP) goal of less than 120 mm Hg vs treating to a goal of less than 140 mm Hg on risk of probable dementia and mild cognitive impairment.
This randomized clinical trial compares the effects of combination paracetamol (acetaminophen) and ibuprofen at full vs half strength vs either drug alone on 24-hour patient-controlled morphine consumption and 90-day serious adverse events after total hip arthroplasty (THA).
This cohort study found that 90-day mortality following elective noncardiac surgery was higher among Veterans Affairs patients with symptomatic or asymptomatic heart failure and reduced left ventricular ejection fraction (LVEF) compared with patients without heart failure.
This study uses Medicare Part D prescription drug plan formulary files to characterize changes in coverage of buprenorphine and buprenorphine-naloxone for opioid use disorder in 2007, 2012, and 2018.
This study characterizes the accuracy of CMS’ Overutilization Monitoring System for correctly identifying prescription opioid users at risk of opioid use disorder (OUD) or overdose between 2011 and 2014.
This 2019 Recommendation Statement from the US Preventive Services Task Force recommends that clinicians provide or refer pregnant and postpartum persons at increased risk of perinatal depression to counseling interventions, such as cognitive behavioral or interpersonal therapy (B recommendation).
This systematic review to support the 2019 US Preventive Services Task Force Recommendation Statement on interventions to prevent perinatal depression summarizes published evidence on the benefits and harms of primary care–relevant interventions to prevent depression during pregnancy or up to 1 year after childbirth.
This Viewpoint summarizes key findings and conclusions of a working group of health care leaders and patient advocates who participated in a 2018 American Board of Internal Medicine (ABIM) Foundation Forum on [Re]Building Trust, convened to identify and prioritize interventions to restore trust in health care teams, standards, measures, and systems.
This Viewpoint argues that adoption of a combination of varenicline, nicotine replacement therapy, and behavioral support as first-line treatment for tobacco addiction could increase smoking cessation rates in the United States and proposes that varenicline be made an over-the-counter medication to help more smokers quit cigarettes and improve population health.
This Viewpoint discusses the growing market for complementary interventions to prevent cognitive impairment and promote brain health, and urges health care professionals to partner with patients to address their health concerns and help them understand the market forces behind unproven treatments.
In this narrative medicine essay a physician recalls the connections she has forged with patients through conversations about their tattoos and reveals how she considers herself tattooed with the narratives and experiences they’ve shared.
This Guide to Statistics and Methods discusses E-value analysis, an alternative approach to sensitivity analyses for unmeasured confounding in observational studies that specifies the degree of unmeasured confounding that would need to be operative to negate observed results in a study.
A previously healthy 7-week-old infant had a 4-week history of a worsening, widespread, papulovesicular rash with nighttime irritability and restlessness; burrows were present, and Gram stain, potassium hydroxide preparation, and Tzanck smear were negative. A babysitter reported having nighttime pruritus. What would you do next?
This Medical News article is an interview with Leana Wen, MD, the new president of Planned Parenthood.
This Arts & Medicine essay reviews the 2018-2019 Broadway revival of The Waverly Gallery, a Kenneth Lonergan play that tells the story of the effects within a well-to-do Manhattan family of the decline of a family member from progressive dementia.
This JAMA Patient Page explains the US Preventive Services Task Force’s 2019 recommendations to provide or refer pregnant and postpartum women at risk of perinatal depression to counseling interventions such as cognitive behavioral therapy and interpersonal therapy.
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