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September 2019 - July 1883

Decade

Year

Issue

February 19, 2019, Vol 321, No. 7, Pages 623-716

In This Issue of JAMA

Highlights

Abstract Full Text
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JAMA. 2019;321(7):623-625. doi:10.1001/jama.2018.15201
Original Investigation

Caring for the Critically Ill Patient

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial

Abstract Full Text
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JAMA. 2019;321(7):654-664. doi:10.1001/jama.2019.0071

This randomized trial compares the effects of resuscitation strategies targeting normalization of capillary refill time vs normalization or decrease of serum lactate levels on 28-day mortality among patients with septic shock.

Caring for the Critically Ill Patient

Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial

Abstract Full Text
free access has active quiz
JAMA. 2019;321(7):665-675. doi:10.1001/jama.2019.0073

This cluster-randomized clinical trial compares the effect of a nurse-led intervention intended to alleviate acute stress and memories of frightening intensive care unit (ICU) experiences vs usual care on patient-reported posttraumatic stress disorder (PTSD) symptom severity 6 months after ICU discharge.

Assessment of the FDA Risk Evaluation and Mitigation Strategy for Transmucosal Immediate-Release Fentanyl Products

Abstract Full Text
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JAMA. 2019;321(7):676-685. doi:10.1001/jama.2019.0235

This study uses FDA documents to describe transmucosal immediate-release fentanyl (TIRF) prescribing patterns after the agency’s 2011 REMS intended to reduce the rate of TIRF-related adverse outcomes, misuse, abuse, addiction, and overdose.

Preliminary Communication

Caring for the Critically Ill Patient

Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial

Abstract Full Text
free access has active quiz has multimedia
JAMA. 2019;321(7):686-696. doi:10.1001/jama.2019.0234

This randomized clinical trial compares the effects of postoperative intravenous acetaminophen vs placebo, combined with intravenous propofol vs dexmedetomidine, on postoperative in-hospital delirium among older patients undergoing cardiac surgery.

Research Letter

Use of Active Surveillance or Watchful Waiting for Low-Risk Prostate Cancer and Management Trends Across Risk Groups in the United States, 2010-2015

Abstract Full Text
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JAMA. 2019;321(7):704-706. doi:10.1001/jama.2018.19941

This cancer epidemiology study uses SEER data to examine US trends in use of active surveillance, watchful waiting, radiotherapy, and surgical management of localized prostate cancer among men with low-, intermediate-, and high-risk disease treated between 2010 and 2015.

Viewpoint

Should Physicians Recommend Replacing Opioids With Cannabis?

Abstract Full Text
JAMA. 2019;321(7):639-640. doi:10.1001/jama.2019.0077

This Viewpoint questions recent US state regulations authorizing the use of cannabis as a substitute for opioids in treatment of opioid addiction and chronic pain, citing the absence of evidence of cannabis equivalency, the risks of marijuana use, and ample evidence supporting the use of methadone and buprenorphine for management of opioid use disorder (OID).

Can Maintenance of Certification Pass the Test?

Abstract Full Text
JAMA. 2019;321(7):641-642. doi:10.1001/jama.2019.0084

This Viewpoint assesses the prospects for reform of maintenance of certification (MOC) programs administered by physician specialty boards, distinguishing between reforms in summative knowledge testing using formal examination and formative programs that support ongoing incremental and personalizable education.

Opioid Prescribing Limits for Acute Pain: Potential Problems With Design and Implementation

Abstract Full Text
JAMA. 2019;321(7):643-644. doi:10.1001/jama.2019.0010

This Viewpoint reviews potential adverse consequences of US state and insurer policy initiatives to limit opioid prescription duration for patients with acute pain and proposes that condition-specific prescribing guidelines and patient-centered approaches could maintain pain control while reducing the risk of diversion and misuse.

A Piece of My Mind

Promoting Sensible Parenting Policies: Leading by Example

Abstract Full Text
JAMA. 2019;321(7):645-646. doi:10.1001/jama.2019.0460

In this narrative medicine essay, a pediatrician recalls how her residency program and peers helped her through a challenging pregnancy and postpartum period, compares herself to women who are not so lucky, and calls on the physician community to advocate for a change in US policy to provide 12-week paid family leave.

Editorial

How Best to Resuscitate Patients With Septic Shock?

Abstract Full Text
JAMA. 2019;321(7):647-648. doi:10.1001/jama.2019.0070

Addressing the Psychological Symptoms of Critical Illness: The Importance of “Negative” Trials in Guiding Next Steps

Abstract Full Text
JAMA. 2019;321(7):649-650. doi:10.1001/jama.2019.0072

Mitigating Health Risks of Prescription Drugs: Lessons From FDA Oversight of Opioid Products

Abstract Full Text
JAMA. 2019;321(7):651-653. doi:10.1001/jama.2019.0236
JAMA Guide to Statistics and Methods

Mediation Analysis

Abstract Full Text
JAMA. 2019;321(7):697-698. doi:10.1001/jama.2018.21973

This JAMA Guide to Statistics and Methods reviews the use of mediation analysis to evaluate possible mechanisms that the effects of interventions are presumed to work through. 

JAMA Clinical Challenge

Blurry Vision and a Black Ink Tattoo

Abstract Full Text
has active quiz
JAMA. 2019;321(7):699-700. doi:10.1001/jama.2018.20671

A 26-year-old white man had recurrent episodes of ocular redness and blurry vision coincident with nodular skin elevation in a left-arm tattoo. Slit lamp examination revealed inflammatory cells in the anterior chamber of the left eye; punch biopsy of the tattooed skin revealed pigment-containing macrophages. What is the diagnosis and what would you do next?

JAMA Diagnostic Test Interpretation

Sweat Chloride Testing

Abstract Full Text
has active quiz
JAMA. 2019;321(7):701-702. doi:10.1001/jama.2018.21998

A 5-year-old girl with a family history of cystic fibrosis presented with constipation, poor weight gain, and a BMI below the third percentile. Three sweat chloride tests were indeterminate, a CFTR analysis panel was negative, and whole-genome sequence analysis revealed 1 cystic fibrosis–causing mutation. What would you do next?

Medical News & Perspectives

Are Probiotics Money Down the Toilet? Or Worse?

Abstract Full Text
JAMA. 2019;321(7):633-635. doi:10.1001/jama.2018.20798

This Medical News article discusses recent studies that question the one-size-fits-all approach to probiotic supplementation for gastrointestinal health, arguing for a more personalized approach.

News From the Food and Drug Administration

Eye-Tracking Test Approved to Help Diagnose Concussion

Abstract Full Text
JAMA. 2019;321(7):638. doi:10.1001/jama.2019.0509

FDA Approves Bacteriophage Trial

Abstract Full Text
JAMA. 2019;321(7):638. doi:10.1001/jama.2019.0510

Measuring Breast Milk Nutrients to Support Optimal Infant Growth

Abstract Full Text
JAMA. 2019;321(7):638. doi:10.1001/jama.2019.0611
The JAMA Forum

Medical Scribes, Productivity, and Satisfaction

Abstract Full Text
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JAMA. 2019;321(7):635-636. doi:10.1001/jama.2019.0268
Global Health

Yemen’s Deadly Cholera Epidemic

Abstract Full Text
JAMA. 2019;321(7):637. doi:10.1001/jama.2019.0151

Hydroxyurea Safe and Effective for Sickle Cell Anemia

Abstract Full Text
JAMA. 2019;321(7):637. doi:10.1001/jama.2019.0592

Multidrug Ebola Trial Underway in Democratic Republic of Congo

Abstract Full Text
JAMA. 2019;321(7):637. doi:10.1001/jama.2019.0593
The Arts and Medicine

Whipped Cream—Viennese Ballet and Pop Surrealism Meet Dark Medicine

Abstract Full Text
JAMA. 2019;321(7):630-631. doi:10.1001/jama.2018.19502

This Arts and Medicine feature reviews the American Ballet Theatre’s 2017 production of Richard Strauss’ Whipped Cream (Schlagobers), a collaboration between choreographer Alexei Ratmansky and pop surrealist Mark Ryden, which tells the story of a boy’s admission to and rescue from a nightmarish hospitalization.

Poetry and Medicine

Beyond Reason

Abstract Full Text
JAMA. 2019;321(7):711. doi:10.1001/jama.2018.14895
JAMA Revisited

Weather and Disease

Abstract Full Text
JAMA. 2019;321(7):712. doi:10.1001/jama.2018.15209
JAMA Patient Page

Surgical Decision Making for Older Adults

Abstract Full Text
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JAMA. 2019;321(7):716. doi:10.1001/jama.2019.0283

This JAMA Patient Page explains aspects of decision making for older patients considering surgery.

Comment & Response

Long-term Follow-up of Antibiotics vs Surgery for Appendicitis

Abstract Full Text
JAMA. 2019;321(7):706. doi:10.1001/jama.2018.19591

Long-term Follow-up of Antibiotics vs Surgery for Appendicitis

Abstract Full Text
JAMA. 2019;321(7):706-707. doi:10.1001/jama.2018.19588

Long-term Follow-up of Antibiotics vs Surgery for Appendicitis—Reply

Abstract Full Text
JAMA. 2019;321(7):707-708. doi:10.1001/jama.2018.19595

Gestational Diabetes and Childhood Obesity

Abstract Full Text
JAMA. 2019;321(7):708. doi:10.1001/jama.2018.19750

Gestational Diabetes and Childhood Obesity—Reply

Abstract Full Text
JAMA. 2019;321(7):708-709. doi:10.1001/jama.2018.19754
Correction

Incomplete Funding

Abstract Full Text
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JAMA. 2019;321(7):709. doi:10.1001/jama.2019.0152

Error in Introduction

Abstract Full Text
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JAMA. 2019;321(7):709. doi:10.1001/jama.2019.0541
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2019;321(7):627-628. doi:10.1001/jama.2018.15202
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