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October 2021 - July 1883




July 2, 2019, Vol 322, No. 1, Pages 3-90

In This Issue of JAMA


Abstract Full Text
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JAMA. 2019;322(1):3-5. doi:10.1001/jama.2018.15399
Original Investigation

Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial

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JAMA. 2019;322(1):37-48. doi:10.1001/jama.2019.8044

This randomized clinical trial assesses 2 subcutaneous tanezumab dosing regimens vs placebo for osteoarthritis of the hip or knee.

Associations of Statewide Legislative and Administrative Interventions With Vaccination Status Among Kindergartners in California

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JAMA. 2019;322(1):49-56. doi:10.1001/jama.2019.7924

This observational study uses yearly cross-sectional school-entry data to calculate changes in rates of kindergartners attending California schools who were not up to date on required vaccinations before and after legislative and administrative initiatives in 2014-2017 intended to increase vaccine uptake.

Association Between the Implementation of a Population-Based Primary Care Payment System and Achievement on Quality Measures in Hawaii

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JAMA. 2019;322(1):57-68. doi:10.1001/jama.2019.8113

This observational study uses Blue Cross Blue Shield claims and clinical registry data to evaluate whether payment reform that provided quality bonuses and a global budget shared savings incentive was associated with changes in health care quality measures, utilization, or spending in the first year of system implementation.

Research Letter

Association Between South Carolina Medicaid’s Change in Payment for Immediate Postpartum Long-Acting Reversible Contraception and Birth Intervals

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JAMA. 2019;322(1):76-78. doi:10.1001/jama.2019.6854

This study evaluates whether a 2012 change in the South Carolina Medicaid policy to reimburse hospitals for provision of immediate postpartum long-acting reversible contraception (IPP-LARC) separately from global payment for all services in a delivery hospitalization was associated with changes in IPP-LARC use and short-interval births between 2010 and 2017.

Survival of Patients With Liver Transplants Donated After Euthanasia, Circulatory Death, or Brain Death at a Single Center in Belgium

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JAMA. 2019;322(1):78-80. doi:10.1001/jama.2019.6553

This study compares graft and patient survival rates after transplantation of livers donated after euthanasia vs after circulatory death or brain death at a hospital in Belgium, where euthanasia is legalized.


State Abortion Restrictions and the New Supreme Court: Women’s Access to Reproductive Health Services

Abstract Full Text
JAMA. 2019;322(1):21-22. doi:10.1001/jama.2019.8437

This Viewpoint reviews the number and types of US state-initiated restrictions on abortion in 2019, their likely effects on compromising women’s access to reproductive health services, and prospects for the overturn of Roe v Wade by the US Supreme Court.

A Troubling Court Decision for Reproductive Rights: Legal Recognition of Fetal Standing to Sue

Abstract Full Text
JAMA. 2019;322(1):23-24. doi:10.1001/jama.2019.7809

This Viewpoint examines a recent case filed in Alabama involving a man naming the aborted fetus as a co-plaintiff in a suit against the manufacturer of an abortion pill and the clinic that provided it to his then-girlfriend who ended her pregnancy at 6 weeks, and the challenges this case could have for reproductive rights in the United States.

Shared Decision Making and the Importance of Time

Abstract Full Text
JAMA. 2019;322(1):25-26. doi:10.1001/jama.2019.3785

This Viewpoint characterizes time as a scarce but vital element of shared patient-clinician decision making and urges development of policies that allocate meaningful time for clinical visits and innovations that create time for physicians to be with patients without compromising access or productivity.

Durable Control of HIV Infection in the Absence of Antiretroviral Therapy: Opportunities and Obstacles

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JAMA. 2019;322(1):27-28. doi:10.1001/jama.2019.5397

This Viewpoint discusses current strategies that are the focus of research on eradication or suppression of virus in individuals infected with HIV without dependence on antiretroviral therapy regimens.

A Piece of My Mind

An Unexpected Asset

Abstract Full Text
JAMA. 2019;322(1):29. doi:10.1001/jama.2019.7995

In this narrative medicine essay, a pediatrician diagnosed with breast cancer draws from her experiences as a medical trainee to help her endure the fear, anxiety, and uncertainty accompanying her disease while pregnant with her second child.


Tanezumab for Painful Osteoarthritis

Abstract Full Text
JAMA. 2019;322(1):30-32. doi:10.1001/jama.2019.8250

Outbreaks of Vaccine-Preventable Diseases: Responding to System Failure With National Vaccination Requirements

Abstract Full Text
JAMA. 2019;322(1):33-34. doi:10.1001/jama.2019.8251

Can Alternative Payment Models Save Primary Care?Lessons From Hawaii for the Nation

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JAMA. 2019;322(1):35-36. doi:10.1001/jama.2019.8254
JAMA Insights

Women's Health

Discussions of Dense Breasts, Breast Cancer Risk, and Screening Choices in 2019

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JAMA. 2019;322(1):69-70. doi:10.1001/jama.2019.6247

This JAMA Insights Clinical Update reviews uncertainties about incorporation of measures of breast density into breast cancer risk prediction models and the need for appropriate screening intervals for women with dense breasts on digital mammography or breast tomosynthesis.

JAMA Clinical Challenge

A Patient With Abnormal Abdominal CT Scan Findings

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JAMA. 2019;322(1):71-72. doi:10.1001/jama.2019.6849

A man with a history of nephrolithiasis and laparotomy for trauma had left flank and left upper quadrant pain. He had mild leukocytosis, but the physical examination and other laboratory testing were unremarkable; abdominal CT revealed a well-circumscribed, extraluminal mass with central high density. What is the diagnosis and what would you do next?

From The Medical Letter on Drugs and Therapeutics

Brexanolone (Zulresso) for Postpartum Depression

Abstract Full Text
JAMA. 2019;322(1):73-74. doi:10.1001/jama.2019.6622

This Medical Letter reviews use of brexanolone, an intravenous γ-aminobutyric acid type A receptor modulator, approved by the US Food and Drug Administration for treatment of postpartum depression.

Medical News & Perspectives

Low Awareness of Scammers’ Tactics Linked to Dementia Risk in Cognitively Normal People

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JAMA. 2019;322(1):13-14. doi:10.1001/jama.2019.5765

This Medical News story discusses a recent study of cognitively normal seniors that found an association between low awareness of scammers’ tactics and subsequent risk of Alzheimer dementia.

Cardiovascular Corner: Low Lipids, Metformin, and Plant-Based Diets

Abstract Full Text
JAMA. 2019;322(1):15-16. doi:10.1001/jama.2019.6544

This Medical News article is an update on important clinical research in the world of heart disease and stroke.

News From the Food and Drug Administration

First PI3K Inhibitor for Breast Cancer

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JAMA. 2019;322(1):19. doi:10.1001/jama.2019.8916

Test Detects Prosthetic Joint Infection in Synovial Fluid

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JAMA. 2019;322(1):19. doi:10.1001/jama.2019.8680

Another Stem Cell Company Is Put On Notice

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JAMA. 2019;322(1):19. doi:10.1001/jama.2019.8917
The JAMA Forum

Medicare for All or Medicare for More?

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JAMA. 2019;322(1):16-17. doi:10.1001/jama.2019.8268
Bench to Bedside

For Alzheimer Pathology, Light and Sound Stimulation May Hold Promise

Abstract Full Text
JAMA. 2019;322(1):17-18. doi:10.1001/jama.2019.8295
The Arts and Medicine

Three Identical Strangers and The Twinning Reaction—Clarifying History and Lessons for Today From Peter Neubauer’s Twins Study

Abstract Full Text
JAMA. 2019;322(1):10-12. doi:10.1001/jama.2019.8152

This Arts and Medicine feature reviews Three Identical Strangers and The Twinning Reaction, 2 documentaries telling the story of identical twins and triplets adopted as infants into separate families who were unknowing participants in a 2-decade nature vs nurture study of child development, beginning in 1960.

Poetry and Medicine


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JAMA. 2019;322(1):85. doi:10.1001/jama.2019.3356
JAMA Revisited

Physical Exercise and Physiologic Fitness

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JAMA. 2019;322(1):86. doi:10.1001/jama.2018.15407
JAMA Patient Page

Home Intravenous Antibiotic Therapy

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JAMA. 2019;322(1):90. doi:10.1001/jama.2019.7424

This JAMA Patient Page describes the utility of and procedures for administering intravenous antibiotics at home.

Comment & Response

Random-Effects Assumption in Meta-analyses

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JAMA. 2019;322(1):81. doi:10.1001/jama.2019.5439

Random-Effects Assumption in Meta-analyses

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JAMA. 2019;322(1):81. doi:10.1001/jama.2019.5443

Random-Effects Assumption in Meta-analyses—Reply

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JAMA. 2019;322(1):82. doi:10.1001/jama.2019.5447

Glucose Control in the Perioperative Period

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JAMA. 2019;322(1):82. doi:10.1001/jama.2019.5833

Glucose Control in the Perioperative Period—Reply

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JAMA. 2019;322(1):82-83. doi:10.1001/jama.2019.5852

Treat-to-Target Strategies in Rheumatoid Arthritis

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JAMA. 2019;322(1):83. doi:10.1001/jama.2019.5848

Treat-to-Target Strategies in Rheumatoid Arthritis—Reply

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JAMA. 2019;322(1):83-84. doi:10.1001/jama.2019.5856

Data Errors

Abstract Full Text
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JAMA. 2019;322(1):84. doi:10.1001/jama.2019.8371
JAMA Masthead


Abstract Full Text
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JAMA. 2019;322(1):7-8. doi:10.1001/jama.2018.15400