This randomized noninferiority clinical trial examines the effect of treatment with the dipeptidyl peptidase-4 inhibitor linagliptin vs the commonly used sulfonylurea glimepiride on cardiovascular safety in patients with type 2 diabetes and cardiovascular risk factors or established atherosclerotic cardiovascular disease.
This cohort study uses data from the National Veterans Health Administration, Medicare, Medicaid, and National Death Index to compare major adverse cardiovascular events among patients with diabetes and reduced kidney function who continued treatment with metformin or sulfonylurea.
This national survey study uses NHANES data to characterize trends in dietary macronutrient intake, food sources, and diet quality among US adults from 1999 to 2016.
This research letter discusses the association between label restrictions by the US Food and Drug Administration on first-line immunotherapy for advanced bladder cancer and subsequent changes in practice.
This 2019 Recommendation Statement from the US Preventive Services Task Force recommends screening pregnant persons for asymptomatic bacteriuria using urine culture (B recommendation) and recommends against screening for asymptomatic bacteriuria in nonpregnant adults (D recommendation).
This systematic review to support the 2019 US Preventive Services Task Force Recommendation Statement on screening for asymptomatic bacteriuria in adults summarizes published evidence on the benefits and harms of asymptomatic bacteriuria screening and treatment in adults, including during pregnancy.
This Viewpoint discusses how problems with the methodology, structure, and recommendations of the Relative Value Scale Update Committee can lead to outdated or inaccurate physician payment data and lower quality of care, and calls for the use of empirical data and patient-specific outcomes to inform physician reimbursement.
This Viewpoint argues for separation of physician performance measurement from RVU production as a means to refocus physicians away from billing toward patient-centered values that could improve patients’ experience, reduce potential harms from the overtreatment that RVUs incentivize, and improve physicians’ work life and satisfaction.
This Viewpoint uses Dinerstein v Google, a class action complaint in Illinois alleging that an academic medical center violated patient privacy by giving timestamped electronic health record (EHR) data to Google for development of their novel EHR system, to review the ways privacy laws like HIPAA are based on outdated technologies and data transfer standards and to call for a rethinking of data sharing governance appropriate to contemporary infrastructure and expectations of interoperability.
This Viewpoint summarizes results of dissemination and implementation research conducted by the US Preventive Services Task Force (USPSTF) to reevaluate the presentation of USPSTF Recommendation Statements and explains changes made to the statements and accompanying materials to increase clarity and enhance implementation of recommendations.
In this narrative medicine essay, a gastroenterologist describes the challenge of diagnosing a partner in his clinic with pancreatic cancer, which came a day short of the median time patients present and are diagnosed with the disease, and reflects on the positive example his colleague had on him, his career, and on the other physicians working at the clinic.
This Medical Letter review summarizes prescribing information for Bijuva, a fixed-dose combination of “bioidentical” estradiol and progesterone, for oral treatment of moderate to severe vasomotor symptoms due to menopause in women with an intact uterus.
This Medical News article discusses recent research that shows increasing their vitamin K intake could help patients who take warfarin to maintain stable anticoagulation.
This Medical News article discusses how pigs, rear-fanged snakes, and dogs may help improve our understanding of brain connectivity, vaccine delivery, and myocardial oxygenation.
This JAMA Patient Page describes the US Preventive Services Task Force’s recent recommendations on screening for asymptomatic bacteriuria in adults.
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