This randomized clinical trial compares the effects of 2 doses of sprifermin, a recombinant human fibroblast growth factor 18, vs placebo on changes in total femorotibial joint cartilage thickness in the knees of patients with osteoarthritis.
This randomized clinical trial compares the effects of a hospital-initiated, nurse-delivered program combining transition of care and long-term self-management support vs transition support alone on 6-month hospitalizations and emergency department (ED) visits among patients hospitalized with chronic obstructive pulmonary disease (COPD).
This genetic epidemiology study uses UK Biobank database data to estimate the association between genetic variants associated with lower low-density lipoprotein cholesterol (LDL-C), lower systolic blood pressure (SBP), or both and cardiovascular disease (CVD), defined as coronary death, nonfatal, myocardial infarction, or coronary revascularization.
This meta-analysis uses individual participant data from observational studies to compare functional disability among patients with cerebellar intracerebral hemorrhage (ICH) managed with surgical hematoma evacuation vs conservative treatment.
This physiology study assesses whole-body heat loss in physically active middle-aged and older men with vs without type 2 diabetes after aerobic cycling to evaluate whether type 2 diabetes impairs heat loss and by what mechanism.
This study assesses the effects of self-dousing and foot immersion on heart rate, core temperature, and thermal discomfort of healthy volunteers randomized to simulated hot and humid vs nonhumid conditions.
This Viewpoint discusses the challenges of communicating uncertain prognosis to patients and offers a framework and language that go past mortality statistics—addressing range of time left, loss of independence, and the unpredictability of outcomes—that embraces uncertainty and might help empower patients to plan for their quality-of-life goals.
This Viewpoint discusses the 2019 Box v Planned Parenthood US Supreme Court ruling that upheld an Indiana provision mandating that abortion facilities bury or cremate fetal remains, characterizing the law as a “targeted restriction” law intended to place undue burden on abortion providers and patients and incrementally reduce access to abortion and related reproductive health services.
This Viewpoint uses recent US state legislation mandating investments in primary care to discuss the lack of evidence supporting assumptions that primary care spending will save downstream health care costs, the reasons why that might be, and implications for policy, payment, and practice reforms.
This Viewpoint reviews conventional ways of assessing performance of machine learning models to diagnose or predict outcomes, but emphasizes that if machine learning is to improve patient care the models must be evaluated for their utility in improving clinical decisions taking into account the range of decisions clinicians can take, the cost and efficacy of those options, and the likelihood that patients will follow the recommended decisions.
In this narrative medicine essay, a psychiatrist describes the defenses he uses against the emotional toll of long days of patient care and recalls a traumatic childhood memory that helps him understand his patients’ fears and anxieties and those of their families.
An asymptomatic 57-year-old man with obesity, hypertension, and dyslipidemia requests screening for diabetes. Would you offer laboratory-based or point-of-care glucose or HbA1c testing?
This Medical Letter review summarizes published evidence on the safety and efficacy of commercially available insect repellents, including DEET, picaridin, and oil of lemon eucalyptus, for repelling mosquitoes, ticks, and other insects, and preventing the infections they transmit.
In this Medical News article, experts discuss sensitive ways to tell older adults that they no longer need cancer screening when their life expectancy is less than 10 years.
This Medical News article discusses a recent study about the effect of fans on relieving the physiological stress of high temperatures.
In this Arts and Medicine feature, a visual artist uses a graphic drawing “comics” format to tell the story of her knee replacement in a New York hospital.
This JAMA Patient Page describes risks, diagnosis, and treatment of pancreatic cancer.
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