This noninferiority randomized trial compares the effects of oral lefamulin vs oral moxifloxacin on clinical response at 96 hours among adult patients with community-acquired bacterial pneumonia.
This randomized trial compares the effect of prophylactic caspofungin vs fluconazole on invasive fungal disease among patients between the ages of 3 months to 30 years with acute myeloid leukemia.
This genome-wide association study (GWAS) investigates genetic loci associated with primary open-angle glaucoma in individuals in Africa and in the United States with African ancestry.
This study compares changes in end-of-life practices (withholding or withdrawing of life-prolonging therapy, active shortening of the dying process, failed CPR, documentation of brain death) in 22 European ICUs between 1999-2000 and 2015-2016.
This study monitored online posts from readers seeking specific health information on a social media platform to evaluate the volume of information requests, whether readers sought an initial or second opinion for diagnosis, and the amount of response time before a reply answer was sent.
This Viewpoint uses provisions in President Trump’s 2019 American Kidney Health Executive order calling for an increase in access to kidney transplantation to discuss strategies to increase deceased and living donor pools, improve allocation of organs from higher-risk donors, and support the long-term medical needs of living donors.
This Viewpoint discusses the importance of structuring value-based purchasing models around principles of physician professionalism to ensure that measures that lead to more payment are clinically meaningful, do not increase administrative burden, do not displace clinicians’ intrinsic motivation to help patients with financial motivations, and do not incentivize physicians to avoid sicker, more complicated patients.
In the context of limited evidence to date that national health care quality improvement (QI) initiatives are effective, this Viewpoint proposes shifting the focus of QI efforts to high-need, high-cost individuals, such as frail older patients and those at the end of life, because they are especially vulnerable to adverse consequences of low-value, high-cost care.
This Viewpoint summarizes recommendations from an International Society for Stem Cell Research task force charged with developing professional standards of patient consent for stem cell–based interventions offered outside a clinical trial given the spread of unregulated stem cell clinics offering unproven therapies.
In this narrative medicine essay, an internal medicine intern with metastatic osteosarcoma tells what it is like to be a patient facing a grave disease and explains that she needs commitment, empathy, and presence from her physicians.
This JAMA Guide to Statistics and Methods reviews the use of whole genome association studies to quantify the association between single-nucleotide polymorphisms (SNPs) and human disease, and the importance of using the information to identify the actual effector transcripts responsible for the underlying pathophysiology.
This JAMA Insights Clinical Update reviews approaches for managing obesity in adolescents, including behavioral interventions, pharmacotherapy, and surgical interventions, with discussion of management considerations unique to this age group.
This Medical Letter review summarizes the indications, adverse effects, and drug interactions of Lefamulin, a semisynthetic pleuromutilin antibiotic approved by the US Food and Drug Administration for intravenous and oral treatment of community-acquired bacterial pneumonia in adults.
This Medical News story profiles Maria Reese, MD, Director of the Shirley Ryan AbilityLab Performing Arts Medicine Program, treating professional and amateur instrumentalists, actors, and dancers from around the country.
In this Medical News article, emergency physician Emmy Betz, MD, MPH, discusses safety issues concerning people with dementia who own or live in a home with firearms.
This JAMA Patient Page describes the causes, symptoms, evaluation, and treatments for dementia.
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