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April 2021 - July 1883

Decade

Year

Issue

November 5, 2019, Vol 322, No. 17, Pages 1625-1728

In This Issue of JAMA

Highlights

Abstract Full Text
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JAMA. 2019;322(17):1625-1627. doi:10.1001/jama.2018.15575
Original Investigation

Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial

Abstract Full Text
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JAMA. 2019;322(17):1661-1671. doi:10.1001/jama.2019.15468

This noninferiority randomized trial compares the effects of oral lefamulin vs oral moxifloxacin on clinical response at 96 hours among adult patients with community-acquired bacterial pneumonia.

Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2019;322(17):1673-1681. doi:10.1001/jama.2019.15702

This randomized trial compares the effect of prophylactic caspofungin vs fluconazole on invasive fungal disease among patients between the ages of 3 months to 30 years with acute myeloid leukemia.

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry

Abstract Full Text
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JAMA. 2019;322(17):1682-1691. doi:10.1001/jama.2019.16161

This genome-wide association study (GWAS) investigates genetic loci associated with primary open-angle glaucoma in individuals in Africa and in the United States with African ancestry.

Caring for the Critically Ill Patient

Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016

Abstract Full Text
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JAMA. 2019;322(17):1692-1704. doi:10.1001/jama.2019.14608

This study compares changes in end-of-life practices (withholding or withdrawing of life-prolonging therapy, active shortening of the dying process, failed CPR, documentation of brain death) in 22 European ICUs between 1999-2000 and 2015-2016.

Research Letter

Requests for Diagnoses of Sexually Transmitted Diseases on a Social Media Platform

Abstract Full Text
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JAMA. 2019;322(17):1712-1713. doi:10.1001/jama.2019.14390

This study monitored online posts from readers seeking specific health information on a social media platform to evaluate the volume of information requests, whether readers sought an initial or second opinion for diagnosis, and the amount of response time before a reply answer was sent.

Viewpoint

The Advancing American Kidney Health Executive Order: An Opportunity to Enhance Organ Donation

Abstract Full Text
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JAMA. 2019;322(17):1645-1646. doi:10.1001/jama.2019.14500

This Viewpoint uses provisions in President Trump’s 2019 American Kidney Health Executive order calling for an increase in access to kidney transplantation to discuss strategies to increase deceased and living donor pools, improve allocation of organs from higher-risk donors, and support the long-term medical needs of living donors.

Value-Based Purchasing and Physician Professionalism

Abstract Full Text
JAMA. 2019;322(17):1647-1648. doi:10.1001/jama.2019.14990

This Viewpoint discusses the importance of structuring value-based purchasing models around principles of physician professionalism to ensure that measures that lead to more payment are clinically meaningful, do not increase administrative burden, do not displace clinicians’ intrinsic motivation to help patients with financial motivations, and do not incentivize physicians to avoid sicker, more complicated patients.

Disappointment in the Value-Based Era: Time for a Fresh Approach?

Abstract Full Text
JAMA. 2019;322(17):1649-1650. doi:10.1001/jama.2019.15918

In the context of limited evidence to date that national health care quality improvement (QI) initiatives are effective, this Viewpoint proposes shifting the focus of QI efforts to high-need, high-cost individuals, such as frail older patients and those at the end of life, because they are especially vulnerable to adverse consequences of low-value, high-cost care.

A Professional Standard for Informed Consent for Stem Cell Therapies

Abstract Full Text
JAMA. 2019;322(17):1651-1652. doi:10.1001/jama.2019.11290

This Viewpoint summarizes recommendations from an International Society for Stem Cell Research task force charged with developing professional standards of patient consent for stem cell–based interventions offered outside a clinical trial given the spread of unregulated stem cell clinics offering unproven therapies.

A Piece of My Mind

Resident Report

Abstract Full Text
JAMA. 2019;322(17):1653-1654. doi:10.1001/jama.2019.16490

In this narrative medicine essay, an internal medicine intern with metastatic osteosarcoma tells what it is like to be a patient facing a grave disease and explains that she needs commitment, empathy, and presence from her physicians.

Editorial

A Measured Dose of Optimism for the Evolution of ICU-Based Palliative Care

Abstract Full Text
JAMA. 2019;322(17):1655-1657. doi:10.1001/jama.2019.12660

The Ninth International Congress on Peer Review and Scientific Publication: A Call for Research

Abstract Full Text
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JAMA. 2019;322(17):1658-1660. doi:10.1001/jama.2019.15516
JAMA Guide to Statistics and Methods

Genome-Wide Association Studies

Abstract Full Text
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JAMA. 2019;322(17):1705-1706. doi:10.1001/jama.2019.16479

This JAMA Guide to Statistics and Methods reviews the use of whole genome association studies to quantify the association between single-nucleotide polymorphisms (SNPs) and human disease, and the importance of using the information to identify the actual effector transcripts responsible for the underlying pathophysiology.

JAMA Insights

Clinical Update

Treatment of Adolescent Obesity in 2020

Abstract Full Text
JAMA. 2019;322(17):1707-1708. doi:10.1001/jama.2019.14725

This JAMA Insights Clinical Update reviews approaches for managing obesity in adolescents, including behavioral interventions, pharmacotherapy, and surgical interventions, with discussion of management considerations unique to this age group.

From The Medical Letter on Drugs and Therapeutics

Lefamulin (Xenleta) for Community-Acquired Bacterial Pneumonia

Abstract Full Text
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JAMA. 2019;322(17):1709-1710. doi:10.1001/jama.2019.16482

This Medical Letter review summarizes the indications, adverse effects, and drug interactions of Lefamulin, a semisynthetic pleuromutilin antibiotic approved by the US Food and Drug Administration for intravenous and oral treatment of community-acquired bacterial pneumonia in adults.

Editor's Note

Lefamulin—A New Antibiotic for Community-Acquired Pneumonia

Abstract Full Text
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JAMA. 2019;322(17):1671-1672. doi:10.1001/jama.2019.16215
Medical News & Perspectives

A Day in the Life: Performing Arts Physician Saves Careers by Fine-tuning Artists’ Form

Abstract Full Text
JAMA. 2019;322(17):1637-1639. doi:10.1001/jama.2019.15208

This Medical News story profiles Maria Reese, MD, Director of the Shirley Ryan AbilityLab Performing Arts Medicine Program, treating professional and amateur instrumentalists, actors, and dancers from around the country.

Firearms and Dementia: “A Big Deal and a Tough Issue”

Abstract Full Text
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JAMA. 2019;322(17):1639-1642. doi:10.1001/jama.2019.15496

In this Medical News article, emergency physician Emmy Betz, MD, MPH, discusses safety issues concerning people with dementia who own or live in a home with firearms.

News From the Food and Drug Administration

PrEP Drug Is Approved for Some Patients but Not for Others

Abstract Full Text
JAMA. 2019;322(17):1644. doi:10.1001/jama.2019.17814

Children With Rare Vasculitis Have New Treatment Option

Abstract Full Text
JAMA. 2019;322(17):1644. doi:10.1001/jama.2019.17531

Enlisting Patients’ Input in Medical Device Trials

Abstract Full Text
JAMA. 2019;322(17):1644. doi:10.1001/jama.2019.17815
The JAMA Forum

Primary Care for All

Abstract Full Text
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JAMA. 2019;322(17):1641-1642. doi:10.1001/jama.2019.16630
Bench to Bedside

Bioinspired Adhesive Dressing Actively Heals Wounds in Animals

Abstract Full Text
JAMA. 2019;322(17):1642-1643. doi:10.1001/jama.2019.16734
Poetry and Medicine

The Hospital Mail

Abstract Full Text
JAMA. 2019;322(17):1721. doi:10.1001/jama.2019.16169
JAMA Revisited

The Relationship Between Herpes Zoster, Syphilis and Chickenpox

Abstract Full Text
JAMA. 2019;322(17):1722. doi:10.1001/jama.2018.15583
JAMA Patient Page

What Is Dementia?

Abstract Full Text
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JAMA. 2019;322(17):1728. doi:10.1001/jama.2019.11653

This JAMA Patient Page describes the causes, symptoms, evaluation, and treatments for dementia.

Comment & Response

Trends in Obesity Among Low-Income Young Children

Abstract Full Text
JAMA. 2019;322(17):1713-1714. doi:10.1001/jama.2019.14220

Trends in Obesity Among Low-Income Young Children—Reply

Abstract Full Text
JAMA. 2019;322(17):1714-1715. doi:10.1001/jama.2019.14247

One vs 12 Months of Dual Antiplatelet Therapy for Patients After Percutaneous Coronary Intervention

Abstract Full Text
JAMA. 2019;322(17):1715. doi:10.1001/jama.2019.14223

1 vs 12 Months of Dual Antiplatelet Therapy for Patients After Percutaneous Coronary Intervention—Reply

Abstract Full Text
JAMA. 2019;322(17):1715-1716. doi:10.1001/jama.2019.14250

Spontaneous Breathing Trials and Successful Extubation

Abstract Full Text
JAMA. 2019;322(17):1716. doi:10.1001/jama.2019.14217

Spontaneous Breathing Trials and Successful Extubation

Abstract Full Text
JAMA. 2019;322(17):1716-1717. doi:10.1001/jama.2019.14226

Spontaneous Breathing Trials and Successful Extubation—Reply

Abstract Full Text
JAMA. 2019;322(17):1717. doi:10.1001/jama.2019.14244

Error in Coding of Questionnaire Scale in Study of Depression in Adolescents

Abstract Full Text
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JAMA. 2019;322(17):1717-1718. doi:10.1001/jama.2019.12855
Correction

Error in Coding of Suicidal Ideation Questionnaire Scale

Abstract Full Text
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JAMA. 2019;322(17):1718. doi:10.1001/jama.2019.16240

Incorrect Y-Axis Labels and Minor Data Errors

Abstract Full Text
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JAMA. 2019;322(17):1718. doi:10.1001/jama.2019.16264

Incorrect Spelling of Author Name, Incorrect Affiliation of Another Author, and Removal of Academic Degree

Abstract Full Text
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JAMA. 2019;322(17):1718. doi:10.1001/jama.2019.16269

Omitted Author Contributions

Abstract Full Text
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JAMA. 2019;322(17):1718. doi:10.1001/jama.2019.17746
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2019;322(17):1629-1630. doi:10.1001/jama.2018.15576
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