This randomized clinical trial compares the efficacy of bempedoic acid, an experimental drug that inhibits an enzyme upstream of HMG-CoA reductase, vs placebo for lowering levels of low-density lipoprotein cholesterol (LDL-C) in patients at high cardiovascular risk with ongoing hypercholesterolemia receiving maximally tolerated lipid-lowering therapy.
This study uses data from the Scientific Registry of Transplant Recipients to investigate the association between transplant center and survival benefit among adult candidates for heart transplant adjusting for case mix and mortality estimates.
This cohort study examines the association of cardiac resynchronization therapy with change in left ventricular ejection fraction (LVEF)among patients with chemotherapy-induced cardiomyopathy.
This study characterizes the percentage of pediatric patients undergoing liver transplant who were up to date for their age on immunizations at the time of transplant and risk factors for underimmunization.
This population epidemiology study uses 2014-2018 data from National Health Interview Surveys to assess trends in prevalence of current and daily e-cigarette use by US adults and to characterize trends by sociodemographic and smoking status among young adults (18-24 years).
This Viewpoint discusses the importance of expanding accountability in quality-based payment reform from clinicians alone to include health systems and patients to align financial incentives for improving health outcomes among all the elements that contribute to the cost and enjoy the benefits of achieving them.
In this Viewpoint, Milton Packer and colleagues argue that reliance on a threshold of LVEF ≤40% to define heart failure with reduced ejection fraction (HFrEF) may exclude patients with impaired systolic function and subnormal LVEF from evidence-based treatments that reduce morbidity and mortality, and the authors propose that the LVEF threshold for HFrEF treatment be increased to ≤50%.
This Viewpoint summarizes a 2019 National Academies of Sciences, Engineering, and Medicine consensus committee report defining 5 priority development areas for the US health care system to integrate social care into health care delivery: designing delivery systems and building workforce, developing digital infrastructure interoperable between health and social care organizations, and funding the integration and research into the effectiveness and implementation of social care practices in health care settings.
This Viewpoint proposes a template for thinking about physician malpractice liability arising from use of artificial intelligence (AI) in clinical practice, and identifies scenarios with and without injury and liability vs based on alignment of AI recommendations with standards of care, AI accuracy, and physician decisions in response.
In this narrative medicine essay, a pediatric ophthalmologist recalls his trip back to his parents’ house to help his father die and contrasts his death with the energetic, robust life his father lived.
This Users’ Guide to the Medical Literature discusses the use of machine learning models as a diagnostic tool, and it explains the important steps needed for making these models and the outcomes they derive clinically effective.
This JAMA Clinical Guidelines Synopsis summarizes the 2019 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines on primary prevention of cardiovascular disease.
This Medical Letter review summarizes drugs available for anticoagulation and rate and rhythm control for use in patients with atrial fibrillation.
This Medical News article discusses how the continuing lack of older adults in oncology studies can affect their treatment outcomes.
The first installment of this new Medical News feature examines the health effects of grapes, blueberries, cilantro, and mushrooms.
Precis: In this chapter excerpt from Samuel Shem’s Man’s 4th Best Hospital, a 2019 sequel to the classic 1978 novel The House of God, Roy Basch reunites with the Fat Man to save a patient’s life, diagnose the ills of electronic health records, and train the next generation of patient-centered physicians.
This JAMA Patient Page describes nonalcoholic fatty liver disease and how it is diagnosed and treated.
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