July 9, 2019, Vol 322, No. 2, Pages 95-180

In This Issue of JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2019;322(2):95-97. doi:10.1001/jama.2018.15410

Audio Editors' Summary: Recombinant Zoster Vaccine After SCT, Procedural Management of Achalasia, Review of Subclinical Hypothyroidism, and more

Original Investigation

Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial

Adriana Bastidas, MD; Javier de la Serna, MD; Mohamed El Idrissi, MSc; et al.

Abstract Full Text

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JAMA. 2019;322(2):123-133. doi:10.1001/jama.2019.9053

This randomized trial compares the effects of 2 doses of nonlive adjuvanted recombinant zoster vaccine vs placebo on incidence of herpes zoster in adults who had undergone autologous hematopoietic stem cell transplantation.

Effect of Peroral Endoscopic Myotomy vs Pneumatic Dilation on Symptom Severity and Treatment Outcomes Among Treatment-Naive Patients With Achalasia: A Randomized Clinical Trial

Fraukje A. Ponds, MD; Paul Fockens, MD, PhD; Aaltje Lei, BSc; et al.

Abstract Full Text

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JAMA. 2019;322(2):134-144. doi:10.1001/jama.2019.8859

This randomized clinical trial compares the effects on symptoms and recurrence of peroral endoscopic myotomy (POEM) vs pneumatic dilation for the initial treatment of idiopathic achalasia.

Editorial
Peroral Endoscopic Myotomy (POEM) vs Pneumatic Dilation: Establishing a New Therapeutic Option for Achalasia
Brian C. Jacobson, MD, MPH; David R. Lichtenstein, MD

Association Between Self-reported Prenatal Cannabis Use and Maternal, Perinatal, and Neonatal Outcomes

Daniel J. Corsi, PhD; Laura Walsh, MSc; Deborah Weiss, PhD; et al.

Abstract Full Text

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JAMA. 2019;322(2):145-152. doi:10.1001/jama.2019.8734

This cohort study uses Canadian registry data to investigate associations between self-reported prenatal cannabis use and preterm birth.

Editorial
Cannabis Use in Pregnancy: A Tale of 2 Concerns
Michael Silverstein, MD, MPH; Elizabeth A. Howell, MD, MPH; Barry Zuckerman, MD

Research Letter

Association Between Medicare and FDA Policies and Prior Authorization Requirements for Buprenorphine Products in Medicare Part D Plans

Tami L. Mark, PhD; William Parish, PhD; Gary A. Zarkin, PhD

Abstract Full Text

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JAMA. 2019;322(2):166-167. doi:10.1001/jama.2019.6581

This study describes changes in the proportion of Medicare Part D plans requiring prior authorization for buprenorphine products before and after a 2017 FDA rquirement that the drug’s label emphasize the importance of drug treatment of opioid use disorder.

Self-reported Medical and Nonmedical Cannabis Use Among Pregnant Women in the United States

Nora D. Volkow, MD; Beth Han, MD, PhD, MPH; Wilson M. Compton, MD, MPE; et al.

Abstract Full Text

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JAMA. 2019;322(2):167-169. doi:10.1001/jama.2019.7982

This study uses National Survey on Drug Use and Health data to examine prevalence and frequency of medical and nonmedical cannabis use among pregnant and nonpregnant women between 2013 and 2017.

Editorial
Cannabis Use in Pregnancy: A Tale of 2 Concerns
Michael Silverstein, MD, MPH; Elizabeth A. Howell, MD, MPH; Barry Zuckerman, MD

Viewpoint

Trust in Health Care

Trust Between Health Care and Community Organizations

Somava Saha Stout, MD, MS; Lisa A. Simpson, MB, BCh, MPH; Prabhjot Singh, MD, PhD

Abstract Full Text

JAMA. 2019;322(2):109-110. doi:10.1001/jama.2019.1211

This Viewpoint discusses the importance of trust in partnerships between health care and community-based organizations for achieving better health outcomes and proposes principles and strategies for building and nurturing trustworthy collaborations.

Editorial
Trust in Health Care
Howard Bauchner, MD
Building Trust in Health Care—Why, Where, and How
Dhruv Khullar, MD, MPP

Trust in Health Care

Building Trust in Health Systems to Eliminate Health Disparities

Donald E. Wesson, MD, MBA; Catherine R. Lucey, MD; Lisa A. Cooper, MD, MPH

Abstract Full Text

JAMA. 2019;322(2):111-112. doi:10.1001/jama.2019.1924

This Viewpoint discusses the historic lack of trust between health systems and underserved communities and suggests evidence-based strategies to build the trusting relationships needed to address this complex social problem.

Editorial
Trust in Health Care
Howard Bauchner, MD
Building Trust in Health Care—Why, Where, and How
Dhruv Khullar, MD, MPP

Reconsidering the Consequences of Using Race to Estimate Kidney Function

Nwamaka Denise Eneanya, MD, MPH; Wei Yang, PhD; Peter Philip Reese, MD, MSCE

Abstract Full Text

JAMA. 2019;322(2):113-114. doi:10.1001/jama.2019.5774

This Viewpoint questions whether the use of race as a variable in the CKD-EPI equation to estimate glomerular filtration rate (eGFR) puts some black patients at a disadvantage with respect to renally cleared antibiotics and access to kidney transplantation, and argues that more objective clinical variables might improve the equation’s precision while avoiding problems with identifying race.

Editorial
Removal of Race From Estimates of Kidney Function: First, Do No Harm
Keith C. Norris, MD; Nwamaka D. Eneanya, MD, MPH; L. Ebony Boulware, MD, MPH

The Review of Systems, the Electronic Health Record, and Billing

Marissa A. Hendrickson, MD; Genevieve B. Melton, MD, PhD; Michael B. Pitt, MD

Abstract Full Text

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JAMA. 2019;322(2):115-116. doi:10.1001/jama.2019.5667

In the context of a Centers for Medicare & Medicaid Services proposal to simplify evaluation and management (E/M) documentation guidelines by 2021, this Viewpoint reviews the problems with current implementation of review-of-systems history taking in electronic health records (EHRs), including information overload, lack of follow-up of findings, clinical irrelevance to some patients and visits, and dishonesty in documentation.

Conversations with Dr Bauchner: The Review of Systems, the Electronic Health Record, and Billing

A Piece of My Mind

The Sound of Silence—When There Are No Words

Melissa Red Hoffman, MD, ND

Abstract Full Text

JAMA. 2019;322(2):117-118. doi:10.1001/jama.2019.8385

In this narrative medicine essay, a surgeon and palliative care physician describes the isolating silence that she felt her after the slaying of her father in Egypt when she was 18 years old and how that lingering silence has come to guide her when sitting with patients, when there are no words.

Editorial

Peroral Endoscopic Myotomy (POEM) vs Pneumatic Dilation: Establishing a New Therapeutic Option for Achalasia

Brian C. Jacobson, MD, MPH; David R. Lichtenstein, MD

Abstract Full Text

JAMA. 2019;322(2):119-120. doi:10.1001/jama.2019.8858

Cannabis Use in Pregnancy: A Tale of 2 Concerns

Michael Silverstein, MD, MPH; Elizabeth A. Howell, MD, MPH; Barry Zuckerman, MD

Abstract Full Text

JAMA. 2019;322(2):121-122. doi:10.1001/jama.2019.8860

Review

Subclinical Hypothyroidism: A Review

Bernadette Biondi, MD; Anne R. Cappola, MD, ScM; David S. Cooper, MD

Abstract Full Text

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JAMA. 2019;322(2):153-160. doi:10.1001/jama.2019.9052

This narrative review summarizes causes of subclinical hyperthyroidism, reviews controversies related to its clinical significance as a risk factor for heart failure, ischemic heart disease, and dementia, and discusses management considerations, including indications for observation vs thyroid hormone supplementation.

Audio Clinical Review: Subclinical Hypothyroidism

JAMA Clinical Guidelines Synopsis

Primary Prevention of Sudden Cardiac Death

Andrew D. Beaser, MD; Adam S. Cifu, MD; Hemal M. Nayak, MD

Abstract Full Text

JAMA. 2019;322(2):161-162. doi:10.1001/jama.2019.7662

This JAMA Clinical Guidelines Synopsis summarizes the 2017 American College of Cardiology/American Heart Association/Heart Rhythm Society guideline on management of patients with ventricular arrhythmias and prevention of sudden cardiac death.

JAMA Diagnostic Test Interpretation

Adenosine Deaminase Diagnostic Testing in Pericardial Fluid

Edward Chau, MD; Minoo Sarkarati, MD; Brad Spellberg, MD

Abstract Full Text

JAMA. 2019;322(2):163-164. doi:10.1001/jama.2019.7535

A 65-year-old man from Vietnam presented with shortness of breath at rest, orthopnea, and lower extremity edema for the past 2 weeks and nonproductive cough and weight loss for the past 4 months. A computed tomographic (CT) scan demonstrated a moderate to large pericardial effusion that was lymphocyte-predominant with a fluid ADA level of 118.1 U/L. What would you do next?

Medical News & Perspectives

Debating Whether Checkups Are Time Wasted or Time Misused

Rita Rubin, MA

Abstract Full Text

JAMA. 2019;322(2):101-102. doi:10.1001/jama.2019.6605

This Medical News story examines the debate over the value of checkups for healthy individuals.

Wild Health

Finding Answers for Enlarged Hearts, Communication Disorders, and How to Swallow Insulin

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2019;322(2):102-103. doi:10.1001/jama.2019.6697

This Medical News article explains how Burmese pythons, singing mice, and the African leopard tortoise may help researchers better understand several debilitating health conditions.

The JAMA Forum