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September 2020 - July 1883




July 9, 2019, Vol 322, No. 2, Pages 95-180

In This Issue of JAMA


Abstract Full Text
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JAMA. 2019;322(2):95-97. doi:10.1001/jama.2018.15410
Original Investigation

Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial

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JAMA. 2019;322(2):123-133. doi:10.1001/jama.2019.9053

This randomized trial compares the effects of 2 doses of nonlive adjuvanted recombinant zoster vaccine vs placebo on incidence of herpes zoster in adults who had undergone autologous hematopoietic stem cell transplantation.

Effect of Peroral Endoscopic Myotomy vs Pneumatic Dilation on Symptom Severity and Treatment Outcomes Among Treatment-Naive Patients With Achalasia: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2019;322(2):134-144. doi:10.1001/jama.2019.8859

This randomized clinical trial compares the effects on symptoms and recurrence of peroral endoscopic myotomy (POEM) vs pneumatic dilation for the initial treatment of idiopathic achalasia.

Association Between Self-reported Prenatal Cannabis Use and Maternal, Perinatal, and Neonatal Outcomes

Abstract Full Text
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JAMA. 2019;322(2):145-152. doi:10.1001/jama.2019.8734

This cohort study uses Canadian registry data to investigate associations between self-reported prenatal cannabis use and preterm birth.

Research Letter

Association Between Medicare and FDA Policies and Prior Authorization Requirements for Buprenorphine Products in Medicare Part D Plans

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JAMA. 2019;322(2):166-167. doi:10.1001/jama.2019.6581

This study describes changes in the proportion of Medicare Part D plans requiring prior authorization for buprenorphine products before and after a 2017 FDA rquirement that the drug’s label emphasize the importance of drug treatment of opioid use disorder.

Self-reported Medical and Nonmedical Cannabis Use Among Pregnant Women in the United States

Abstract Full Text
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JAMA. 2019;322(2):167-169. doi:10.1001/jama.2019.7982

This study uses National Survey on Drug Use and Health data to examine prevalence and frequency of medical and nonmedical cannabis use among pregnant and nonpregnant women between 2013 and 2017.


Trust in Health Care

Trust Between Health Care and Community Organizations

Abstract Full Text
JAMA. 2019;322(2):109-110. doi:10.1001/jama.2019.1211

This Viewpoint discusses the importance of trust in partnerships between health care and community-based organizations for achieving better health outcomes and proposes principles and strategies for building and nurturing trustworthy collaborations.

Trust in Health Care

Building Trust in Health Systems to Eliminate Health Disparities

Abstract Full Text
JAMA. 2019;322(2):111-112. doi:10.1001/jama.2019.1924

This Viewpoint discusses the historic lack of trust between health systems and underserved communities and suggests evidence-based strategies to build the trusting relationships needed to address this complex social problem.

Reconsidering the Consequences of Using Race to Estimate Kidney Function

Abstract Full Text
JAMA. 2019;322(2):113-114. doi:10.1001/jama.2019.5774

This Viewpoint questions whether the use of race as a variable in the CKD-EPI equation to estimate glomerular filtration rate (eGFR) puts some black patients at a disadvantage with respect to renally cleared antibiotics and access to kidney transplantation, and argues that more objective clinical variables might improve the equation’s precision while avoiding problems with identifying race.

The Review of Systems, the Electronic Health Record, and Billing

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JAMA. 2019;322(2):115-116. doi:10.1001/jama.2019.5667

In the context of a Centers for Medicare & Medicaid Services proposal to simplify evaluation and management (E/M) documentation guidelines by 2021, this Viewpoint reviews the problems with current implementation of review-of-systems history taking in electronic health records (EHRs), including information overload, lack of follow-up of findings, clinical irrelevance to some patients and visits, and dishonesty in documentation.

A Piece of My Mind

The Sound of Silence—When There Are No Words

Abstract Full Text
JAMA. 2019;322(2):117-118. doi:10.1001/jama.2019.8385

In this narrative medicine essay, a surgeon and palliative care physician describes the isolating silence that she felt her after the slaying of her father in Egypt when she was 18 years old and how that lingering silence has come to guide her when sitting with patients, when there are no words.


Peroral Endoscopic Myotomy (POEM) vs Pneumatic Dilation: Establishing a New Therapeutic Option for Achalasia

Abstract Full Text
JAMA. 2019;322(2):119-120. doi:10.1001/jama.2019.8858

Cannabis Use in Pregnancy: A Tale of 2 Concerns

Abstract Full Text
JAMA. 2019;322(2):121-122. doi:10.1001/jama.2019.8860

Subclinical Hypothyroidism: A Review

Abstract Full Text
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JAMA. 2019;322(2):153-160. doi:10.1001/jama.2019.9052

This narrative review summarizes causes of subclinical hyperthyroidism, reviews controversies related to its clinical significance as a risk factor for heart failure, ischemic heart disease, and dementia, and discusses management considerations, including indications for observation vs thyroid hormone supplementation.

JAMA Clinical Guidelines Synopsis

Primary Prevention of Sudden Cardiac Death

Abstract Full Text
JAMA. 2019;322(2):161-162. doi:10.1001/jama.2019.7662

This JAMA Clinical Guidelines Synopsis summarizes the 2017 American College of Cardiology/American Heart Association/Heart Rhythm Society guideline on management of patients with ventricular arrhythmias and prevention of sudden cardiac death.

JAMA Diagnostic Test Interpretation

Adenosine Deaminase Diagnostic Testing in Pericardial Fluid

Abstract Full Text
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JAMA. 2019;322(2):163-164. doi:10.1001/jama.2019.7535

A 65-year-old man from Vietnam presented with shortness of breath at rest, orthopnea, and lower extremity edema for the past 2 weeks and nonproductive cough and weight loss for the past 4 months. A computed tomographic (CT) scan demonstrated a moderate to large pericardial effusion that was lymphocyte-predominant with a fluid ADA level of 118.1 U/L. What would you do next?

Medical News & Perspectives

Debating Whether Checkups Are Time Wasted or Time Misused

Abstract Full Text
JAMA. 2019;322(2):101-102. doi:10.1001/jama.2019.6605

This Medical News story examines the debate over the value of checkups for healthy individuals.

Wild Health

Finding Answers for Enlarged Hearts, Communication Disorders, and How to Swallow Insulin

Abstract Full Text
JAMA. 2019;322(2):102-103. doi:10.1001/jama.2019.6697

This Medical News article explains how Burmese pythons, singing mice, and the African leopard tortoise may help researchers better understand several debilitating health conditions.

The JAMA Forum

Heritable Genome Editing: Is a Moratorium Needed?

Abstract Full Text
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JAMA. 2019;322(2):104-105. doi:10.1001/jama.2019.8977

Risk, Benefit, and Fairness in a Big Data World

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JAMA. 2019;322(2):105-106. doi:10.1001/jama.2019.9523
News From the Centers for Disease Control and Prevention

Diabetes Incidence Decreases

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JAMA. 2019;322(2):108. doi:10.1001/jama.2019.8668

Medical Tourism–Linked Infections

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JAMA. 2019;322(2):108. doi:10.1001/jama.2019.9205
Biotech Innovations

Patient Receives First Genetically Engineered Phage Treatment

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JAMA. 2019;322(2):107. doi:10.1001/jama.2019.9394

Biomarker Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Abstract Full Text
JAMA. 2019;322(2):107. doi:10.1001/jama.2019.8890

Smartphone-Based Detection of Middle Ear Fluid

Abstract Full Text
JAMA. 2019;322(2):107. doi:10.1001/jama.2019.9395
Poetry and Medicine


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JAMA. 2019;322(2):175. doi:10.1001/jama.2019.4325
JAMA Revisited

Current Comment

Abstract Full Text
JAMA. 2019;322(2):176. doi:10.1001/jama.2018.15418
JAMA Patient Page

Subclinical Hypothyroidism

Abstract Full Text
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JAMA. 2019;322(2):180. doi:10.1001/jama.2019.9508

This JAMA Patient Page describes subclinical hypothyroidism and its causes, symptoms, and treatment.

Comment & Response

Analysis of Long-term Benefits of Intensive Blood Pressure Control

Abstract Full Text
JAMA. 2019;322(2):169-170. doi:10.1001/jama.2019.5840

Analysis of Long-term Benefits of Intensive Blood Pressure Control—Reply

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JAMA. 2019;322(2):170. doi:10.1001/jama.2019.5860

Limiting Opioid Prescribing

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JAMA. 2019;322(2):170-171. doi:10.1001/jama.2019.5844

Limiting Opioid Prescribing—Reply

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JAMA. 2019;322(2):171-172. doi:10.1001/jama.2019.5864

Resuscitation Strategies Using Peripheral Perfusion vs Serum Lactate Levels

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JAMA. 2019;322(2):172. doi:10.1001/jama.2019.6027

Resuscitation Strategies Using Peripheral Perfusion vs Serum Lactate Levels

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JAMA. 2019;322(2):172-173. doi:10.1001/jama.2019.6031

Resuscitation Strategies Using Peripheral Perfusion vs Serum Lactate Levels—Reply

Abstract Full Text
JAMA. 2019;322(2):173. doi:10.1001/jama.2019.6035

Misalignment in Table and Typographical Errors in Text and Figure

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JAMA. 2019;322(2):174. doi:10.1001/jama.2019.8629

Omitted Conflict of Interest Disclosures

Abstract Full Text
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JAMA. 2019;322(2):174. doi:10.1001/jama.2019.9011
JAMA Masthead


Abstract Full Text
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JAMA. 2019;322(2):99-100. doi:10.1001/jama.2018.15411