This noninferiority randomized clinical trial compared the effect of external beam single-fraction 8-Gy radiotherapy vs 20 Gy of radiotherapy in 5 fractions over 5 days on ambulatory status among patients with spinal canal compression from metastatic prostate, lung, and other cancer.
This study uses 2019 National Youth Tobacco Survey data to estimate the prevalence of e-cigarette use among high school and middle school students and the frequency of use, brands used (JUUL, blu, and others), and use of flavored products.
This study pools data from 34 cohorts participating in the CKD Prognosis Consortium developed a risk equation to predict risk of incident chronic kidney disease (CKD) defined as an estimated glomerular filtration rate of less than 60 mL/min/1.73 m2.
This exploratory analysis of data from the Moving to Opportunity for Fair Housing Demonstration Program, a HUD-sponsored social experiment that randomized public housing families to receive a restricted (low-poverty) vs unrestricted (Section 8) relocation voucher, compares the effects of the program on hospitalization rates and days and hospital spending.
This national survey study characterizes JUUL e-cigarette flavors (mint, mango, fruit, and others) most often used by US middle school and high school students in 2019.
This national database study compares pertussis hospitalizations among infants before and after the 2012 Advisory Committee on Immunization Practices recommendation that all pregnant women receive the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine.
In this Viewpoint, John Ioannidis discusses the proliferation of observational studies and news about lifestyle exposures that have trivial and often imprecise associations with meaningful public health outcomes, and proposes ways scientific journals and the media can prioritize the dissemination of balanced, true, science-based information that addresses major public health burdens and are likely to be true.
This Viewpoint uses the example of the successes and failures of the tobacco industry’s Master Settlement Agreement to suggest a framework for redressing the current US opioid epidemic.
In the context of a concerning increase in rates of syphilis and congenital syphilis in the United States, this Viewpoint discusses the importance of improving screening programs and diagnostics, and it argues for legislation, media coverage, and activism by patient advocacy groups and policy makers to remove the stigma of this resurgent sexually transmitted infection (STI).
This Viewpoint reviews the features of managed care organizations (MCOs) and managed competition, which seek to incentivize high-quality care and control spending through care coordination and shared financial risk and savings, and argues that the 2 are imperfect approaches to health care and payment reform but the most promising options for controlling costs short of price controls.
In this narrative medicine essay, a hematologist/oncologist and a nurse practitioner couple tell of a terrifying change in the behavior of their intellectually challenged son and of the physician who discovered the cause.
This Insights update reviews use and accuracy of the 9-item Patient Health Questionnaire (PHQ-9) for depression screening, establishing depression severity, and monitoring responses to treatment.
A 30-year-old man with palpitations and heart rate 241/min had a temperature of 38.2°C, an erythematous oropharynx, tonsillar exudates, and a positive rapid strep test result; an ECG showed narrow complex tachycardia with an incomplete right bundle-branch block–like morphology, a right inferior axis, and atrioventricular dissociation. What is the diagnosis and what would you do next?
A 59-year-old man taking warfarin for recurrent VTE has a point-of-care (POC) international normalized ratio (INR) value of 3.7 (target 2.0 to 3.0). What would you do next?
This Medical News article discusses the top-viewed Original Investigations and Special Communications published across the JAMA Network over 12 months.
This Medical News article discusses recent developments in neurology and neuroscience related to glioma progression, immunizations and multiple sclerosis, and deep brain stimulation for tinnitus.
In this Arts and Medicine feature, a palliative care physician uses Claude Viver’s opera Kopernikus, which represents the experience of death of a young woman to draw connections between the art and the questions clinicians face guiding dying patients and their families from terminal delirium into death.
This JAMA Patient Page describes paraesophageal hernia and its symptoms, diagnosis, and treatment.
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