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May 2021 - July 1883




December 3, 2019, Vol 322, No. 21, Pages 2043-2146

In This Issue of JAMA


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JAMA. 2019;322(21):2043-2045. doi:10.1001/jama.2018.15619
Original Investigation

Effect of Single-Fraction vs Multifraction Radiotherapy on Ambulatory Status Among Patients With Spinal Canal Compression From Metastatic Cancer: The SCORAD Randomized Clinical Trial

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JAMA. 2019;322(21):2084-2094. doi:10.1001/jama.2019.17913

This noninferiority randomized clinical trial compared the effect of external beam single-fraction 8-Gy radiotherapy vs 20 Gy of radiotherapy in 5 fractions over 5 days on ambulatory status among patients with spinal canal compression from metastatic prostate, lung, and other cancer.

e-Cigarette Use Among Youth in the United States, 2019

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JAMA. 2019;322(21):2095-2103. doi:10.1001/jama.2019.18387

This study uses 2019 National Youth Tobacco Survey data to estimate the prevalence of e-cigarette use among high school and middle school students and the frequency of use, brands used (JUUL, blu, and others), and use of flavored products.

Development of Risk Prediction Equations for Incident Chronic Kidney Disease

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JAMA. 2019;322(21):2104-2114. doi:10.1001/jama.2019.17379

This study pools data from 34 cohorts participating in the CKD Prognosis Consortium developed a risk equation to predict risk of incident chronic kidney disease (CKD) defined as an estimated glomerular filtration rate of less than 60 mL/min/1.73 m2.

Association of Receipt of a Housing Voucher With Subsequent Hospital Utilization and Spending

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JAMA. 2019;322(21):2115-2124. doi:10.1001/jama.2019.17432

This exploratory analysis of data from the Moving to Opportunity for Fair Housing Demonstration Program, a HUD-sponsored social experiment that randomized public housing families to receive a restricted (low-poverty) vs unrestricted (Section 8) relocation voucher, compares the effects of the program on hospitalization rates and days and hospital spending.

Research Letter

Flavors of e-Cigarettes Used by Youths in the United States

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JAMA. 2019;322(21):2132-2134. doi:10.1001/jama.2019.17968

This national survey study characterizes JUUL e-cigarette flavors (mint, mango, fruit, and others) most often used by US middle school and high school students in 2019.

Trends in Infant Pertussis Hospitalizations in the United States, 2009-2017

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JAMA. 2019;322(21):2134-2136. doi:10.1001/jama.2019.15577

This national database study compares pertussis hospitalizations among infants before and after the 2012 Advisory Committee on Immunization Practices recommendation that all pregnant women receive the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine.


Neglecting Major Health Problems and Broadcasting Minor, Uncertain Issues in Lifestyle Science

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JAMA. 2019;322(21):2069-2070. doi:10.1001/jama.2019.17576

In this Viewpoint, John Ioannidis discusses the proliferation of observational studies and news about lifestyle exposures that have trivial and often imprecise associations with meaningful public health outcomes, and proposes ways scientific journals and the media can prioritize the dissemination of balanced, true, science-based information that addresses major public health burdens and are likely to be true.

The Opioid Crisis, Corporate Responsibility, and Lessons From the Tobacco Master Settlement Agreement

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JAMA. 2019;322(21):2071-2072. doi:10.1001/jama.2019.17144

This Viewpoint uses the example of the successes and failures of the tobacco industry’s Master Settlement Agreement to suggest a framework for redressing the current US opioid epidemic.

Ending Congenital Syphilis

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JAMA. 2019;322(21):2073-2074. doi:10.1001/jama.2019.17031

In the context of a concerning increase in rates of syphilis and congenital syphilis in the United States, this Viewpoint discusses the importance of improving screening programs and diagnostics, and it argues for legislation, media coverage, and activism by patient advocacy groups and policy makers to remove the stigma of this resurgent sexually transmitted infection (STI).

To Control Costs Expand Managed Care and Managed Competition

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JAMA. 2019;322(21):2075-2076. doi:10.1001/jama.2019.17147

This Viewpoint reviews the features of managed care organizations (MCOs) and managed competition, which seek to incentivize high-quality care and control spending through care coordination and shared financial risk and savings, and argues that the 2 are imperfect approaches to health care and payment reform but the most promising options for controlling costs short of price controls.

A Piece of My Mind

Measuring Quality

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JAMA. 2019;322(21):2077-2078. doi:10.1001/jama.2019.18730

In this narrative medicine essay, a hematologist/oncologist and a nurse practitioner couple tell of a terrifying change in the behavior of their intellectually challenged son and of the physician who discovered the cause.


Predicting Risk of Kidney Disease: Is Risk-Based Kidney Care on the Horizon?

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JAMA. 2019;322(21):2079-2081. doi:10.1001/jama.2019.17378

Housing Mobility and Addressing Social Determinants of Health Within the Health Care System

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JAMA. 2019;322(21):2082-2083. doi:10.1001/jama.2019.18384
JAMA Insights

Using the 9-Item Patient Health Questionnaire to Screen for and Monitor Depression

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JAMA. 2019;322(21):2125-2126. doi:10.1001/jama.2019.15883

This Insights update reviews use and accuracy of the 9-item Patient Health Questionnaire (PHQ-9) for depression screening, establishing depression severity, and monitoring responses to treatment.

JAMA Clinical Challenge

A Man With Incessant Narrow Complex Tachycardia

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JAMA. 2019;322(21):2127-2128. doi:10.1001/jama.2019.16560

A 30-year-old man with palpitations and heart rate 241/min had a temperature of 38.2°C, an erythematous oropharynx, tonsillar exudates, and a positive rapid strep test result; an ECG showed narrow complex tachycardia with an incomplete right bundle-branch block–like morphology, a right inferior axis, and atrioventricular dissociation. What is the diagnosis and what would you do next?

JAMA Diagnostic Test Interpretation

The Point-of-Care INR Test for Vitamin K Antagonist Monitoring

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JAMA. 2019;322(21):2129-2130. doi:10.1001/jama.2019.15720

A 59-year-old man taking warfarin for recurrent VTE has a point-of-care (POC) international normalized ratio (INR) value of 3.7 (target 2.0 to 3.0). What would you do next?

Medical News & Perspectives

JAMA Network Articles of the Year 2019

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JAMA. 2019;322(21):2061-2064. doi:10.1001/jama.2019.18830

This Medical News article discusses the top-viewed Original Investigations and Special Communications published across the JAMA Network over 12 months.

Neuro Nook—Deep Brain Stimulation for Tinnitus, Tumors Hijack Neurons in Brain Cancer, and Multiple Sclerosis and Immunizations

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JAMA. 2019;322(21):2065-2066. doi:10.1001/jama.2019.17957

This Medical News article discusses recent developments in neurology and neuroscience related to glioma progression, immunizations and multiple sclerosis, and deep brain stimulation for tinnitus.

News From the Food and Drug Administration

Clarithromycin-Resistant H pylori Faces New Foe

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JAMA. 2019;322(21):2068. doi:10.1001/jama.2019.19479

Patients With Cystic Fibrosis Have New Triple-Drug Combination

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JAMA. 2019;322(21):2068. doi:10.1001/jama.2019.19351

New Report Examines Drug Shortages

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JAMA. 2019;322(21):2068. doi:10.1001/jama.2019.19480
Bench to Bedside

Exploring the Potential of CAR-T Therapy for Heart Failure

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JAMA. 2019;322(21):2066-2067. doi:10.1001/jama.2019.18942
The Arts and Medicine

Terminal Delirium in the Opera Kopernikus

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JAMA. 2019;322(21):2058-2059. doi:10.1001/jama.2019.18865

In this Arts and Medicine feature, a palliative care physician uses Claude Viver’s opera Kopernikus, which represents the experience of death of a young woman to draw connections between the art and the questions clinicians face guiding dying patients and their families from terminal delirium into death.

Poetry and Medicine

Writing Poems About Patients

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JAMA. 2019;322(21):2139. doi:10.1001/jama.2019.17959
JAMA Revisited

The New Bacchus

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JAMA. 2019;322(21):2140. doi:10.1001/jama.2018.15627
JAMA Patient Page

What Is a Paraesophageal Hernia?

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JAMA. 2019;322(21):2146. doi:10.1001/jama.2019.17395

This JAMA Patient Page describes paraesophageal hernia and its symptoms, diagnosis, and treatment.

Comment & Response

Population-Based Primary Care Payment System in Hawaii

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JAMA. 2019;322(21):2136. doi:10.1001/jama.2019.16200

Population-Based Primary Care Payment System in Hawaii—Reply

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JAMA. 2019;322(21):2136-2137. doi:10.1001/jama.2019.16203

Using Patient Preferences to Determine Noninferiority Margins in Trials

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JAMA. 2019;322(21):2137-2138. doi:10.1001/jama.2019.16336

Using Patient Preferences to Determine Noninferiority Margins in Trials—Reply

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JAMA. 2019;322(21):2138. doi:10.1001/jama.2019.16345

Errors in Results Section

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JAMA. 2019;322(21):2138. doi:10.1001/jama.2019.19012

Error in Figure

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JAMA. 2019;322(21):2138. doi:10.1001/jama.2019.19018
JAMA Masthead


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JAMA. 2019;322(21):2047-2048. doi:10.1001/jama.2018.15620