This randomized clinical trial compares the effect of fresh vs standard-use red blood cell (RBC) transfusions to determine the effect on new or worsening organ dysfunction in critically ill pediatric patients.
This study assesses the association between the TTR V122I variant and prevalent heart failure in individuals with African and Hispanic/Latino ancestry and identifies rates of hereditary transthyretin amyloid cardiomyopathy (hATTR-CM) diagnosis among carriers with heart failure.
This cohort study uses Danish population-based registry data and the Danish Infertility Cohort to examine the association between fertility drugs and treatment procedures (in vitro fertilization, intracytoplasmic sperm injection, frozen embryo transfer) and cancer risk in children.
This study uses Health Care Cost Institute data to assess the share of total health care spending on primary care among individuals younger than 65 years covered by employer-sponsored insurance from 2013 to 2017.
This study characterizes hepatitis C virus (HCV) testing and the HCV care cascade among 13- to 21-year-olds accessing US federally qualified health centers.
This 2019 Recommendation Statement from the US Preventive Services Task Force recommends 1-time ultrasound screening for abdominal aortic aneurysm (AAA) in men aged 65-75 who have ever smoked (B recommendation), selective screening in men aged 65-75 who have never smoked (C recommendation), against routine screening in women who have never smoked and have no family AAA history (D recommendation), and concludes that current evidence is insufficient to assess the balance of benefits and harms of screening in women aged 65-75 who have ever smoked or have a family AAA history (I statement).
This systematic review to support the 2019 US Preventive Services Task Force Recommendation Statement on screening for abdominal aortic aneurysm (AAA) summarizes published evidence on the benefits and harms of AAA screening and treatment in asymptomatic adults older than 50 years.
This Viewpoint summarizes recommendations from the National Academy of Medicine’s Committee on Systems Approaches to Improve Patient Care by Supporting Clinician Well-Being, which proposes creation of more positive work and learning environments, reduction of administrative burdens, development of human-centered technology, provision of health support to physicians, and investments in research to better balance the work demands with resources available to clinicians.
This Viewpoint reviews the importance of culture to expressions of mental health symptoms, definitions of disease, and response to treatment, and argues for integration of transcultural contexts to future disease taxonomies (eg, DSM-6 and ICD-12) to optomize global care of mental illness.
This Viewpoint proposes that object-relations theory, the idea that humans rely on transitional objects for comfort in the absence of human sources of emotional connection, explains people’s connections to their smartphones and can be used to leverage patients’ engagement with digital health apps.
This Viewpoint uses the case of adalimumab (Humira), the most profitable biologic drug sold in the United States, to discuss factors that limit product competition and the ability of the public to access less expensive but comparably effective biosimilars.
In this narrative medicine essay, a black surgeon becomes invisible in the hospital when she removes her white coat, allowing her to observe the differences in how white colleagues, coworkers, and patients are treated compared with black colleagues, coworkers, and patients.
This JAMA Insights Clinical Update summarizes treatment options for individuals with chronic idiopathic constipation, irritable bowel syndrome with constipation, and opioid-induced constipation and summarizes recent guidelines that conclude that traditional laxatives should be used as first-line agents for the management of constipation because of low cost and high benefit.
This JAMA Clinical Guidelines Synopsis summarizes the 2018 American Gastroenterological Association guideline on medical management of opioid-induced constipation.
This Medical News story discusses what is known about the much-hyped compound cannabidiol (CBD).
This Medical News story discusses research into the effects of napping on cardiovascular disease risk.
This JAMA Patient Page describes the US Preventive Services Task Force’s recent recommendations on screening for abdominal aortic aneurysm.
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