This randomized clinical trial compares the effect of early intensive and sustained vasodilation (using nitrates, hydralazine, renin-angiotensin inhibitors, and sacubitril-valsartan) vs usual care on a composite outcome of all-cause mortality and acute heart failure rehospitalization at 180 days among patients with acute heart failure.
This noninferiority trial compares the effect of rocuronium vs succinylcholine on first-attempt tracheal intubation success rate in out-of-hospital emergency situations among patients undergoing rapid sequence intubation.
This study uses registry data to compare stroke and death outcomes for patients with carotid artery stenosis undergoing transcarotid artery revascularization vs transfemoral carotid artery stenting.
This study uses Department of Health and Human Services data to analyze surveillance of electronic health records for patient safety issues to identify those with a potential for patient harm, and the frequency of these issues.
This study used data from the National Vital Statistics System Mortality to evaluate trends in US drug overdose deaths involving opioids certified as unintentional, suicide, or undetermined intent.
This Viewpoint reviews evidence for the benefits of polypills, corrects misconceptions about what they are and where and in whom they should be used, and outlines uncertainties that should be accounted for in strategies and research to increase their use.
With rates of cardiovascular disease (CVD) no longer declining, this Viewpoint explains the pros and cons of 2 divergent strategies to addressing CVD—the polypill vs precision medicine—and summarizes how a clinical trial could help clinicians and health systems determine which approach is best for patients.
This Viewpoint discusses the conditions that need to be in place for the wealth of patient data available in electronic health records to be converted into useful prediction scores usable by clinicians to make clinical decisions.
This Viewpoint discusses the appropriateness of existing US Food and Drug Administration regulatory pathways for artificial intelligence (AI) and machine learning (ML) software in health care, and proposes a lifecyle-based framework given the iterative nature of AI/ML algorithms, including prespecified “safe harbor” provisions for change and postapproval audits of accuracy.
In this narrative medicine essay, an internist recalls how a patient with metastatic hepatocellular cancer forces him into mindfulness through bravery and gratitude following the disclosure that patient’s treatment options are exhausted.
This Rational Clinical Examination systematic review characterizes the accuracy of clinical and x-ray findings associated with hip osteoarthritis.
This JAMA Insights summary reviews the presence and differential diagnosis of ischemia with no evidence of obstructive coronary artery disease (INOCA) in women, and proposes an approach for diagnosis and management of microvascular disease based on empirical therapy and noninvasive and invasive testing.
A 40-year-old woman with Graves disease presented with abdominal pain and constipation. Thyroid-stimulating hormone was undetectable and physical examination revealed a tender midline abdominal mass. Three months earlier she was evaluated for 3 to 4 months of amenorrhea, and a urine human chorionic gonadotropin test was negative for pregnancy. What would you do next?
This Medical News article discusses how culturally appropriate dietary advice may aid in combatting chronic illnesses.
This Medical News story discusses a meta-analysis that shows a more convincing link between psoriasis and the risk of developing and dying of cancer than previous studies had reported.
This JAMA Patient Page describes coronary microvascular dysfunction and the procedures for testing for this condition.
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