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August 2019 - July 1883

Decade

Year

Issue

July 23/30, 2019, Vol 322, No. 4, Pages 285-376

In This Issue of JAMA

Highlights

Abstract Full Text
free access has audio
JAMA. 2019;322(4):285-287. doi:10.1001/jama.2018.15432
Original Investigation

Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial

Abstract Full Text
has active quiz
JAMA. 2019;322(4):315-325. doi:10.1001/jama.2019.9055

This randomized trial compares the effects of 2 doses of filgotinib vs placebo on the signs and symptoms of rheumatoid arthritis in a treatment-refractory population.

Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial

Abstract Full Text
JAMA. 2019;322(4):326-335. doi:10.1001/jama.2019.9346

This randomized clinical trial compares the effects of continuous intravenous vs subcutaneous sliding scale insulin for treatment of hyperglycemia during acute ischemic stroke on functional outcome in adult patients in the United States.

Neuroimaging Findings in US Government Personnel With Possible Exposure to Directional Phenomena in Havana, Cuba

Abstract Full Text
JAMA. 2019;322(4):336-347. doi:10.1001/jama.2019.9269

Between 2016 and 2018, US government personnel stationed in Havana, Cuba, reported exposure to unusual auditory and sensory phenomena followed by neurological signs and symptoms characterized clinically as cognitive, vestibular, and oculomotor dysfunction with sleep impairment and headaches. This study characterizes magnetic resonance–based differences in brain tissue volume, microstructure, and functional connectivity in those personnel compared with demographically similar unexposed controls.

Research Letter

Screening for Hepatitis B Infection in Pregnant Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Abstract Full Text
has audio
JAMA. 2019;322(4):360-362. doi:10.1001/jama.2019.1655

This systematic review to support the 2019 US Preventive Services Task Force Recommendation Statement on screening for hepatitis B infection in pregnant women summarizes published evidence on the benefits and harms of hepatitis B infection screening and case management in pregnant women.

Characteristics of Hospitals That Did and Did Not Join the Bundled Payments for Care Improvement–Advanced Program

Abstract Full Text
JAMA. 2019;322(4):362-364. doi:10.1001/jama.2019.7992

This study describes the characteristics of hospitals participating vs not participating and remaining vs leaving the 2018 CMS Bundled Payments for Care Improvement–Advanced Program (BPCI-A), a payment reform model that reimburses for a 90-day episode of care rather than for individual services.

US Preventive Services Task Force

Recommendation Statement

Screening for Hepatitis B Virus Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement

Abstract Full Text
free access has active quiz has audio
JAMA. 2019;322(4):349-354. doi:10.1001/jama.2019.9365

This 2019 Recommendation Statement from the US Preventive Services Task Force reaffirms the prior recommendation to screen pregnant women for hepatitis B virus infection at their first prenatal visit (A recommendation).

Viewpoint

Health Policy

Pharmacy Benefit Manager Reform: Lessons From Ohio

Abstract Full Text
JAMA. 2019;322(4):299-300. doi:10.1001/jama.2019.7104

This Viewpoint reviews recent efforts in Ohio to regulate pharmacy benefit managers (PBMs) in response to anticompetitive practices and discusses PBM reform as a means of ensuring patient access to affordable drugs.

A Practical Approach to Low-Dose Aspirin for Primary Prevention

Abstract Full Text
has audio
JAMA. 2019;322(4):301-302. doi:10.1001/jama.2019.8388

This Viewpoint discusses use of aspirin for primary prevention of atherosclerotic cardiovascular disease in the context of 3 large 2018 trials demonstrating bleeding risks comparable with benefits, and it proposes a practical stepwise approach to help physicians and patients decide whether to initiate, continue, or discontinue aspirin use.

Realignment of EMS Reimbursement Policy: New Hope for Patient-Centered Out-of-Hospital Care

Abstract Full Text
JAMA. 2019;322(4):303-304. doi:10.1001/jama.2019.7488

This Viewpoint reviews Centers for Medicare and Medicaid Services’ Emergency Triage, Treat, and Transport (ET3) model, a voluntary payment model that will reimburse emergency medical service (EMS) agencies for handling 911 calls with non–emergency department dispositions including on-scene or telemedicine treatment and transport to alternative sites (urgent care clinics, physician offices, behavioral health centers), and outlines the patient safety, quality, and regulatory issues that must be addressed for the concept to move from demonstration project to established policy.

Incorporating Patient Preferences in Noninferiority Trials

Abstract Full Text
JAMA. 2019;322(4):305-306. doi:10.1001/jama.2019.7059

This Viewpoint discusses the selection and interpretation of noninferiority margins (ΔNIs) in noninferiority trials, reviews techniques for eliciting patient preferences for treatment, and calls for using those preferences to select ΔNIs to better achieve patient-centered trade-offs between efficacy loss for nonefficacy gains represented by the margin.

A Piece of My Mind

Comic Relief

Abstract Full Text
free access
JAMA. 2019;322(4):307-308. doi:10.1001/jama.2019.9733

In this narrative medicine essay, an academic hospitalist explores her infatuation with Kate McKinnon, SNL comedian, understanding that it comes from a need to escape the sorrow of her patients’ stories and seriousness of medicine.

Editorial

Filgotinib, a JAK1 Inhibitor, for Treatment-Resistant Rheumatoid Arthritis

Abstract Full Text
JAMA. 2019;322(4):309-311. doi:10.1001/jama.2019.9056

Hepatitis B Screening in Pregnant Women: A Perspective on the New USPSTF Recommendations

Abstract Full Text
JAMA. 2019;322(4):312-314. doi:10.1001/jama.2019.8252
JAMA Insights

Clinical Update

Management of Hepatitis C in 2019

Abstract Full Text
JAMA. 2019;322(4):355-356. doi:10.1001/jama.2019.5353

This JAMA Insights Clinical Update reviews current standards of management of HCV infection, including use of antibody and RNA tests to identify infected patients, use of direct acting antivirals (DAAs) to obtain sustained viral response (SVR), and management of treatment failure.

JAMA Clinical Challenge

Oral and Penile Lesions in a Young Man

Abstract Full Text
has active quiz
JAMA. 2019;322(4):357-358. doi:10.1001/jama.2019.7804

An HIV-negative, immunocompetent man had nonproductive cough and erosive oral mucosal and penile lesions. Mycoplasma pneumoniae titers were elevated but results of chest radiography and other laboratory testing, including STI and bacterial and viral cultures of the lesions, were negative. What is the diagnosis and what would you do next?

Editor's Note

Advanced Neuroimaging Findings in US Government Personnel With Possible Directional Phenomenon Exposure in Havana, Cuba

Abstract Full Text
free access
JAMA. 2019;322(4):348. doi:10.1001/jama.2019.9746
Medical News & Perspectives

Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence

Abstract Full Text
has audio
JAMA. 2019;322(4):291-293. doi:10.1001/jama.2019.7936

This Medical News story examines the popularity of the “Marik protocol,” a combination of high–dose vitamin C, corticosteroids, and thiamine to treat sepsis.

Uncovering a Link Between the Appendix and Parkinson Disease Risk

Abstract Full Text
JAMA. 2019;322(4):293-294. doi:10.1001/jama.2019.9041

This Medical News story discusses recent research examining whether the appendix plays a role in Parkinson disease risk.

News From the Centers for Disease Control and Prevention

Surviving Cancer Costs

Abstract Full Text
free access
JAMA. 2019;322(4):297. doi:10.1001/jama.2019.9666

Breast Milk for Preemies

Abstract Full Text
free access
JAMA. 2019;322(4):297. doi:10.1001/jama.2019.10106
Clinical Trials Update

Preventing Cardiotoxicity Associated With Breast Cancer Therapy

Abstract Full Text
free access
JAMA. 2019;322(4):296. doi:10.1001/jama.2019.9782

Esketamine Nasal Spray Effective in Treatment-Resistant Depression

Abstract Full Text
free access
JAMA. 2019;322(4):296. doi:10.1001/jama.2019.10368

Yoga for Anxiety and Depression Associated With Parkinson Disease

Abstract Full Text
free access
JAMA. 2019;322(4):296. doi:10.1001/jama.2019.10369

Antibiotics Prevented Maternal Infections After Vaginal Delivery

Abstract Full Text
free access
JAMA. 2019;322(4):296. doi:10.1001/jama.2019.10370

Progesterone and Early Pregnancy Bleeding

Abstract Full Text
free access
JAMA. 2019;322(4):296. doi:10.1001/jama.2019.10371
Health Agencies Update

Task Force to Prevent Veteran Suicides

Abstract Full Text
free access
JAMA. 2019;322(4):295. doi:10.1001/jama.2019.9854

Cancer Mortality Continues to Decline

Abstract Full Text
free access
JAMA. 2019;322(4):295. doi:10.1001/jama.2019.10366

NIH Director Takes Stand Against “Manels”

Abstract Full Text
free access
JAMA. 2019;322(4):295. doi:10.1001/jama.2019.10367
Poetry and Medicine

Next of Kin

Abstract Full Text
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JAMA. 2019;322(4):371. doi:10.1001/jama.2019.4365
JAMA Revisited

Smile and Say “Cheese”

Abstract Full Text
free access
JAMA. 2019;322(4):372. doi:10.1001/jama.2018.15440
JAMA Patient Page

Screening for Hepatitis B in Pregnant Women

Abstract Full Text
free access
JAMA. 2019;322(4):376. doi:10.1001/jama.2019.9229

This JAMA Patient Page describes the US Preventive Services Task Force’s recommendations on screening for hepatitis B virus infection in pregnant women.

Comment & Response

Improving Usability of Health Information Technology

Abstract Full Text
JAMA. 2019;322(4):364-365. doi:10.1001/jama.2019.6455

Improving Usability of Health Information Technology—Reply

Abstract Full Text
JAMA. 2019;322(4):365. doi:10.1001/jama.2019.6479

Multinutrient Supplementation for Prevention of Major Depressive Disorder in Overweight Adults

Abstract Full Text
JAMA. 2019;322(4):366. doi:10.1001/jama.2019.6467

Multinutrient Supplementation for Prevention of Major Depressive Disorder in Overweight Adults—Reply

Abstract Full Text
JAMA. 2019;322(4):366-367. doi:10.1001/jama.2019.6483

Collaborative Care for Adults With Obesity and Depression

Abstract Full Text
JAMA. 2019;322(4):367-368. doi:10.1001/jama.2019.6774

Collaborative Care for Adults With Obesity and Depression—Reply

Abstract Full Text
JAMA. 2019;322(4):368. doi:10.1001/jama.2019.6778
Correction

Data Errors and Incorrect Version of Clinical Prediction Tool Used

Abstract Full Text
free access
JAMA. 2019;322(4):369. doi:10.1001/jama.2019.9521

Unclear Statement

Abstract Full Text
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JAMA. 2019;322(4):369. doi:10.1001/jama.2019.9668
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2019;322(4):289-290. doi:10.1001/jama.2018.15433
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