This randomized trial compares the effects of 2 doses of filgotinib vs placebo on the signs and symptoms of rheumatoid arthritis in a treatment-refractory population.
This randomized clinical trial compares the effects of continuous intravenous vs subcutaneous sliding scale insulin for treatment of hyperglycemia during acute ischemic stroke on functional outcome in adult patients in the United States.
Between 2016 and 2018, US government personnel stationed in Havana, Cuba, reported exposure to unusual auditory and sensory phenomena followed by neurological signs and symptoms characterized clinically as cognitive, vestibular, and oculomotor dysfunction with sleep impairment and headaches. This study characterizes magnetic resonance–based differences in brain tissue volume, microstructure, and functional connectivity in those personnel compared with demographically similar unexposed controls.
This systematic review to support the 2019 US Preventive Services Task Force Recommendation Statement on screening for hepatitis B infection in pregnant women summarizes published evidence on the benefits and harms of hepatitis B infection screening and case management in pregnant women.
This study describes the characteristics of hospitals participating vs not participating and remaining vs leaving the 2018 CMS Bundled Payments for Care Improvement–Advanced Program (BPCI-A), a payment reform model that reimburses for a 90-day episode of care rather than for individual services.
This 2019 Recommendation Statement from the US Preventive Services Task Force reaffirms the prior recommendation to screen pregnant women for hepatitis B virus infection at their first prenatal visit (A recommendation).
This Viewpoint reviews recent efforts in Ohio to regulate pharmacy benefit managers (PBMs) in response to anticompetitive practices and discusses PBM reform as a means of ensuring patient access to affordable drugs.
This Viewpoint discusses use of aspirin for primary prevention of atherosclerotic cardiovascular disease in the context of 3 large 2018 trials demonstrating bleeding risks comparable with benefits, and it proposes a practical stepwise approach to help physicians and patients decide whether to initiate, continue, or discontinue aspirin use.
This Viewpoint reviews Centers for Medicare and Medicaid Services’ Emergency Triage, Treat, and Transport (ET3) model, a voluntary payment model that will reimburse emergency medical service (EMS) agencies for handling 911 calls with non–emergency department dispositions including on-scene or telemedicine treatment and transport to alternative sites (urgent care clinics, physician offices, behavioral health centers), and outlines the patient safety, quality, and regulatory issues that must be addressed for the concept to move from demonstration project to established policy.
This Viewpoint discusses the selection and interpretation of noninferiority margins (ΔNIs) in noninferiority trials, reviews techniques for eliciting patient preferences for treatment, and calls for using those preferences to select ΔNIs to better achieve patient-centered trade-offs between efficacy loss for nonefficacy gains represented by the margin.
In this narrative medicine essay, an academic hospitalist explores her infatuation with Kate McKinnon, SNL comedian, understanding that it comes from a need to escape the sorrow of her patients’ stories and seriousness of medicine.
This JAMA Insights Clinical Update reviews current standards of management of HCV infection, including use of antibody and RNA tests to identify infected patients, use of direct acting antivirals (DAAs) to obtain sustained viral response (SVR), and management of treatment failure.
An HIV-negative, immunocompetent man had nonproductive cough and erosive oral mucosal and penile lesions. Mycoplasma pneumoniae titers were elevated but results of chest radiography and other laboratory testing, including STI and bacterial and viral cultures of the lesions, were negative. What is the diagnosis and what would you do next?
This Medical News story examines the popularity of the “Marik protocol,” a combination of high–dose vitamin C, corticosteroids, and thiamine to treat sepsis.
This Medical News story discusses recent research examining whether the appendix plays a role in Parkinson disease risk.
This JAMA Patient Page describes the US Preventive Services Task Force’s recommendations on screening for hepatitis B virus infection in pregnant women.