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June 2022 - July 1883




August 20, 2019, Vol 322, No. 7, Pages 589-702

In This Issue of JAMA


Abstract Full Text
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JAMA. 2019;322(7):589-591. doi:10.1001/jama.2018.15465
Original Investigation

Effect of Continuing Olanzapine vs Placebo on Relapse Among Patients With Psychotic Depression in Remission: The STOP-PD II Randomized Clinical Trial

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JAMA. 2019;322(7):622-631. doi:10.1001/jama.2019.10517

This randomized clinical trial compares the effect on relapse of continuing olanzapine vs placebo among patients with psychotic depression who achieved remission of psychosis and depressive symptoms while taking olanzapine and sertraline.

Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis

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JAMA. 2019;322(7):632-641. doi:10.1001/jama.2019.10931

This individual participant data meta-analysis pooled data from 19 cohort studies to assess whether maternal thyroid function test abnormalities and thyroid autoimmunity are risk factors for preterm birth among pregnant women without overt thyroid disease.

Association of Smoking Cessation With Subsequent Risk of Cardiovascular Disease

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JAMA. 2019;322(7):642-650. doi:10.1001/jama.2019.10298

This cohort study uses Framingham Heart Study data to assess the association between years since smoking cessation and incident cardiovascular disease (CVD), compared with current and never smoking, among participants without baseline CVD over a median follow-up of 26 years.

Research Letter

Prevalence and Characteristics of Virginia Hospitals Suing Patients and Garnishing Wages for Unpaid Medical Bills

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JAMA. 2019;322(7):691-692. doi:10.1001/jama.2019.9144

This study uses 2017 court records to characterize how frequently Virginia hospitals take legal action to garnish patients’ wages to recover unpaid medical expenses, and the characteristics of hospitals and patient employers associated with the actions.

US Preventive Services Task Force

Recommendation Statement

Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement

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JAMA. 2019;322(7):652-665. doi:10.1001/jama.2019.10987

This 2019 Recommendation Statement from the US Preventive Services Task Force recommends that women with a family or personal history associated with increased risk for harmful mutations in the BRCA1/2 genes and with a positive result on a brief familial risk assessment tool should receive genetic counseling and, if indicated, genetic testing (B recommendation) and recommends against routine risk assessment, genetic counseling, or genetic testing for women whose personal or family history is not associated with potentially harmful BRCA1/2 gene mutations (D recommendation).

Evidence Report

Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

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JAMA. 2019;322(7):666-685. doi:10.1001/jama.2019.8430

This systematic review to support the 2019 US Preventive Services Task Force Recommendation Statement on risk assessment, genetic counseling, and genetic testing for BRCA-related cancer summarizes published evidence on the benefits and harms of assessment, counseling, and testing in women without recently diagnosed BRCA1/2-related cancer.


The Conundrum of the United States Medical Licensing Examination Score Reporting Structure

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JAMA. 2019;322(7):605-606. doi:10.1001/jama.2019.9669

In the context of joint preliminary recommendations from the Federation of State Medical Boards and the National Board of Medical Examiners to consider moving the USMLE examination to pass-fail score reporting, this Viewpoint discusses how the current 3-digit score reporting structure is used by residency program directors and medical schools, how it may distract students from developing qualities of innovation and humanism important to medicine, and how it may facilitate workforce underrepresentation of some student groups.

A New Supreme Court Ruling on Drug Liability

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JAMA. 2019;322(7):607-608. doi:10.1001/jama.2019.8515

In May 2019 the US Supreme Court sent back to lower courts the question of whether Merck Sharpe & Dohme Corp was liable for atypical fractures from its osteoporosis drug alendronate because it did not identify the adverse effect in the product’s label. This Viewpoint discusses the legal questions of liability raised by the case and the implication of the decision for the pharmaceutical industry and for patients alleging harmed from prescription drugs.

Protecting Pregnant Women With Substance Use Disorders and Their Neonates Participating in Research

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JAMA. 2019;322(7):609-610. doi:10.1001/jama.2019.9002

This Viewpoint discusses the potential risks faced by pregnant women with substance use disorders who participate in clinical research, including criminal prosecution for drug use while pregnant and custody loss of their children, and proposes changes to research procedures and disclosure provisions to encourage their participation so the evidence base informing their care and addressing the opioid epidemic more generally can advance.

Electronic Fetal Monitoring to Prevent Fetal Brain Injury: A Ubiquitous Yet Flawed Tool

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JAMA. 2019;322(7):611-612. doi:10.1001/jama.2019.8918

This Viewpoint argues that the near-universal adoption of electronic fetal monitoring (EFM) in labor and delivery units has occurred without evidence that it has reduced adverse neurological events and has contributed to an increase in US cesarean delivery rates, and calls for the education of physicians and the public about EFM’s demonstrated reliability and value.

A Piece of My Mind

A Tale of Two Lungs

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JAMA. 2019;322(7):613-614. doi:10.1001/jama.2019.11287

In this narrative medicine essay, a critical care physician works through lessons he learned from his experience with a man with end-stage lung disease going into terminal respiratory failure who consented to intubation only if he had a chance for a lung transplant and considers how to balance patient autonomy with medical paternalism when good outcomes are unlikely and the best decisions are uncertain.


Maintenance Treatment for Psychotic Depressive Disorders: Progress and Remaining Challenges

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JAMA. 2019;322(7):615-617. doi:10.1001/jama.2019.9682

Thyroid Function Test Abnormalities During Pregnancy

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JAMA. 2019;322(7):617-619. doi:10.1001/jama.2019.10159

Broadening Criteria for BRCA1/2 Evaluation: Placing the USPSTF Recommendation in Context

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JAMA. 2019;322(7):619-621. doi:10.1001/jama.2019.9688
JAMA Insights

Catheter Ablation for Atrial Fibrillation in 2019

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JAMA. 2019;322(7):686-687. doi:10.1001/jama.2019.10929

This JAMA Insights Clinical Update reviews management approaches to atrial fibrillation (AF), including assessment of the need for anticoagulation, and controversies over the need for rhythm control and the role of catheter ablation for maintaining sinus rhythm and reducing AF-associated symptoms.

JAMA Clinical Challenge

Electrocardiographic Diagnosis of Atrial Arrhythmias

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JAMA. 2019;322(7):688-689. doi:10.1001/jama.2019.10925

This Clinical Challenge reviews ways to distinguish atrial ectopy, AV block, multifocal atrial tachycardia, and other supraventricular tachycardias from atrial fibrillation in patients with absent P waves, irregularly irregular R-R intervals, and f waves on electrocardiography.

Editor's Note

Smoking Cessation and Reduction of Cardiovascular Disease Risk

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JAMA. 2019;322(7):651. doi:10.1001/jama.2019.11166
Medical News & Perspectives

Weighing the Risks and Rewards of Peanut Oral Immunotherapy

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JAMA. 2019;322(7):596-598. doi:10.1001/jama.2019.9142

This Medical News article discusses a recent meta-analysis of oral immunotherapy trials for people with peanut allergies.

Getting Social: Physicians Can Counteract Misinformation With an Online Presence

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JAMA. 2019;322(7):598-600. doi:10.1001/jama.2019.10779

This Medical News interview discusses the value of social media for health care.

News From the Food and Drug Administration

Ventilator Recall

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JAMA. 2019;322(7):604. doi:10.1001/jama.2019.11803

Another Option for Hypoactive Sexual Desire

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JAMA. 2019;322(7):604. doi:10.1001/jama.2019.11515

First Treatment for Rare Autoimmune Neuromyelitis

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JAMA. 2019;322(7):604. doi:10.1001/jama.2019.11804
The JAMA Forum

Averting Alert Fatigue to Prevent Adverse Drug Reactions

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JAMA. 2019;322(7):601. doi:10.1001/jama.2019.11710
Global Health

Gag Rule May Increase Abortions

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JAMA. 2019;322(7):603. doi:10.1001/jama.2019.11062

Viruses Drive Children’s Pneumonia

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JAMA. 2019;322(7):603. doi:10.1001/jama.2019.11801

Fighting Epilepsy Stigma

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JAMA. 2019;322(7):603. doi:10.1001/jama.2019.11802
JAMA Infographic

Prevalence and Treatment of Chronic Obstructive Pulmonary Disease (COPD) in the United States

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JAMA. 2019;322(7):602. doi:10.1001/jama.2019.10241
Poetry and Medicine

Playing Word Games

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JAMA. 2019;322(7):698. doi:10.1001/jama.2019.5687
JAMA Revisited
JAMA Patient Page

Should I Be Tested for BRCA Mutations?

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JAMA. 2019;322(7):702. doi:10.1001/jama.2019.11251

This JAMA Patient Page describes the US Preventive Services Task Force’s recently published recommendations on risk assessment and genetic counseling and testing for BRCA mutations and BRCA-related cancers.

Comment & Response

Monitoring Adherence to Inhaled Medications

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JAMA. 2019;322(7):692-693. doi:10.1001/jama.2019.8643

Monitoring Adherence to Inhaled Medications—Reply

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JAMA. 2019;322(7):693-694. doi:10.1001/jama.2019.8654

Resuming Anticoagulation After Cerebral Intraparenchymal Hemorrhage

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JAMA. 2019;322(7):694. doi:10.1001/jama.2019.8650

Resuming Anticoagulation After Cerebral Intraparenchymal Hemorrhage—Reply

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JAMA. 2019;322(7):694-695. doi:10.1001/jama.2019.8658

Treating Hypercholesterolemia in Older Adults

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JAMA. 2019;322(7):695. doi:10.1001/jama.2019.8803

Treating Hypercholesterolemia in Older Adults—Reply

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JAMA. 2019;322(7):695-696. doi:10.1001/jama.2019.8807

Clarification of Reporting of Potential Conflicts of Interest in JAMA Articles

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JAMA. 2019;322(7):696. doi:10.1001/jama.2019.11051

Clarification of Reporting of Potential Conflicts of Interest

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JAMA. 2019;322(7):696. doi:10.1001/jama.2019.11017

Numbers of Patients Transposed in Text

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JAMA. 2019;322(7):696. doi:10.1001/jama.2019.11119
JAMA Masthead


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JAMA. 2019;322(7):593-594. doi:10.1001/jama.2018.15466