This randomized trial compares the effects of 400 vs 4000 vs 10 000 IU of vitamin D on total volumetric bone mineral density and bone strength of the radius and tibia.
This randomized trial compares the effect of intensification of consolidation therapy using sequential or “tandem” vs single autologous transplant after induction therapy on event-free survival among children and young adults with high-risk neuroblastoma.
This population epidemiology study uses US National Vital Statistics System data to describe trends in life expectancy at age 25 among US adults by race and education level and contributions of specific causes of death to between-group differences in those trends between 2000 and 2017.
This study evaluates the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research to compare trends in heart disease, stroke, diabetes, and hypertension mortality rates by race and sex from 1999 to 2017.
This Viewpoint discusses the how changing opt-in to opt-out policies for organ donors may impede US donation and recommends to increase efforts in recruiting individuals to become donors to meet the need of helping people who need transplants.
This Viewpoint argues for integration of price information in electronic health records (EHRs) as a mechanism to increase price transparency and promote cost-conscious, patient-centered, shared decision making at the point of care.
This Viewpoint reviews the discrepancy in prices paid for hospital services by commercial insurers vs Medicare and Medicaid, and calls for greater hospital accountability, cost transparency, and data to guide pricing so that the cost of services are benchmarked to the value they offer patients and paying employers rather than the negotiating leverage of health care organizations.
This Viewpoint argues that the language distinguishing evidence-based from consensus-based clinical guidelines is misleading because both require consensus, and argues that it is more accurate to distinguish evidence-based guidelines, which require recommendations consistent with underlying evidence, from non–evidence-based guidelines, which do not.
In this narrative medicine essay, a physiatrist recalls his role in telling his wife of her diagnosis of metastatic ovarian cancer, his support during her inexorable decline, and how the experiences of her passing drew his family closer, nurtured his appreciation for relationships, the wonder of nature, and the renewed sense of connection to the world.
This narrative review summarizes advances in molecular testing for mutations in non–small cell lung cancer, selection of molecularly targeted therapies based on those mutations, and the use of PD-1 inhibitor immunotherapies for the management of metastatic and stage III nonmetastatic disease.
This JAMA insights clinical update reviews menstruation-based criteria for defining menopause in women, the physiologic changes underlying menopausal transition, and how and when to use testing to counsel women about the timing and duration of the transition.
This JAMA Clinical Guidelines Synopsis describes the 2018 American Heart Association/American Stroke Association guidelines for management of patients with acute ischemic stroke.
This Medical News article examines the increasing incidence of herpes zoster ophthalmicus—shingles of the eye—and the need for more widespread vaccination against shingles.
This Quick Uptakes discusses a recent study that compared the long-term physical health effects of childbirth vs abortion among women with unwanted pregnancies.
This Arts and Medicine feature reviews the case made by physician-essayist Lewis Thomas that all prospective medical students be required to know classical Greek language and literature before medical school acceptance and broadens the argument, calling on medical school admissions committees to require an undergraduate major in humanities as a basis for medical education.
This JAMA Patient Page describes reasons for use of chest tubes and the process of chest tube insertion and removal.