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September 2023 - July 1883




August 27, 2019, Vol 322, No. 8, Pages 703-792

In This Issue of JAMA


Abstract Full Text
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JAMA. 2019;322(8):703-705. doi:10.1001/jama.2018.15476
Original Investigation

Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial

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JAMA. 2019;322(8):736-745. doi:10.1001/jama.2019.11889

This randomized trial compares the effects of 400 vs 4000 vs 10 000 IU of vitamin D on total volumetric bone mineral density and bone strength of the radius and tibia.

Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial

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JAMA. 2019;322(8):746-755. doi:10.1001/jama.2019.11642

This randomized trial compares the effect of intensification of consolidation therapy using sequential or “tandem” vs single autologous transplant after induction therapy on event-free survival among children and young adults with high-risk neuroblastoma.

Association Between Educational Attainment and Causes of Death Among White and Black US Adults, 2010-2017

Abstract Full Text
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JAMA. 2019;322(8):756-763. doi:10.1001/jama.2019.11330

This population epidemiology study uses US National Vital Statistics System data to describe trends in life expectancy at age 25 among US adults by race and education level and contributions of specific causes of death to between-group differences in those trends between 2000 and 2017.

Research Letter

Trends in Cardiometabolic Mortality in the United States, 1999-2017

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JAMA. 2019;322(8):780-782. doi:10.1001/jama.2019.9161

This study evaluates the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research to compare trends in heart disease, stroke, diabetes, and hypertension mortality rates by race and sex from 1999 to 2017.


Success of Opt-In Organ Donation Policy in the United States

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JAMA. 2019;322(8):719-720. doi:10.1001/jama.2019.9187

This Viewpoint discusses the how changing opt-in to opt-out policies for organ donors may impede US donation and recommends to increase efforts in recruiting individuals to become donors to meet the need of helping people who need transplants.

Redefining the Physician’s Role in Cost-Conscious Care: The Potential Role of the Electronic Health Record

Abstract Full Text
JAMA. 2019;322(8):721-722. doi:10.1001/jama.2019.9114

This Viewpoint argues for integration of price information in electronic health records (EHRs) as a mechanism to increase price transparency and promote cost-conscious, patient-centered, shared decision making at the point of care.

Health Policy

The Commercial Differential for Hospital Prices: Responses From States and Employers

Abstract Full Text
JAMA. 2019;322(8):723-724. doi:10.1001/jama.2019.9275

This Viewpoint reviews the discrepancy in prices paid for hospital services by commercial insurers vs Medicare and Medicaid, and calls for greater hospital accountability, cost transparency, and data to guide pricing so that the cost of services are benchmarked to the value they offer patients and paying employers rather than the negotiating leverage of health care organizations.

Evidence vs Consensus in Clinical Practice Guidelines

Abstract Full Text
JAMA. 2019;322(8):725-726. doi:10.1001/jama.2019.9751

This Viewpoint argues that the language distinguishing evidence-based from consensus-based clinical guidelines is misleading because both require consensus, and argues that it is more accurate to distinguish evidence-based guidelines, which require recommendations consistent with underlying evidence, from non–evidence-based guidelines, which do not.

A Piece of My Mind

A Difficult Conversation

Abstract Full Text
JAMA. 2019;322(8):727-728. doi:10.1001/jama.2019.11757

In this narrative medicine essay, a physiatrist recalls his role in telling his wife of her diagnosis of metastatic ovarian cancer, his support during her inexorable decline, and how the experiences of her passing drew his family closer, nurtured his appreciation for relationships, the wonder of nature, and the renewed sense of connection to the world.


Tandem Transplant for High-Risk Neuroblastoma: Next Steps in the Era of Precision Medicine

Abstract Full Text
JAMA. 2019;322(8):729-731. doi:10.1001/jama.2019.11641

Reporting and Interpretation of Randomized Clinical Trials

Abstract Full Text
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JAMA. 2019;322(8):732-735. doi:10.1001/jama.2019.12056

Systemic Therapy for Locally Advanced and Metastatic Non–Small Cell Lung Cancer: A Review

Abstract Full Text
JAMA. 2019;322(8):764-774. doi:10.1001/jama.2019.11058

This narrative review summarizes advances in molecular testing for mutations in non–small cell lung cancer, selection of molecularly targeted therapies based on those mutations, and the use of PD-1 inhibitor immunotherapies for the management of metastatic and stage III nonmetastatic disease.

JAMA Insights

Diagnosing the Onset of Menopause

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JAMA. 2019;322(8):775-776. doi:10.1001/jama.2019.6250

This JAMA insights clinical update reviews menstruation-based criteria for defining menopause in women, the physiologic changes underlying menopausal transition, and how and when to use testing to counsel women about the timing and duration of the transition.

JAMA Clinical Guidelines Synopsis

Management of Patients With Acute Ischemic Stroke

Abstract Full Text
JAMA. 2019;322(8):777-778. doi:10.1001/jama.2019.10436

This JAMA Clinical Guidelines Synopsis describes the 2018 American Heart Association/American Stroke Association guidelines for management of patients with acute ischemic stroke.

Medical News & Perspectives

Increasing Cases of Shingles in the Eye Raise Key Questions

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JAMA. 2019;322(8):712-714. doi:10.1001/jama.2019.10743

This Medical News article examines the increasing incidence of herpes zoster ophthalmicus—shingles of the eye—and the need for more widespread vaccination against shingles.

Quick Uptakes

Among Women Seeking Abortion, Continuing Pregnancy Linked to Worse Physical Health

Abstract Full Text
JAMA. 2019;322(8):714-715. doi:10.1001/jama.2019.10313

This Quick Uptakes discusses a recent study that compared the long-term physical health effects of childbirth vs abortion among women with unwanted pregnancies.

News From the Centers for Disease Control and Prevention

Less Addictive Cigarettes

Abstract Full Text
JAMA. 2019;322(8):718. doi:10.1001/jama.2019.11369

Rising PrEP Awareness

Abstract Full Text
has audio
JAMA. 2019;322(8):718. doi:10.1001/jama.2019.11853
Clinical Trials Update

Vitamin D Doesn’t Protect Against Diabetes

Abstract Full Text
JAMA. 2019;322(8):717. doi:10.1001/jama.2019.11564

Improving Stroke Preparedness Among Blacks and Hispanics

Abstract Full Text
JAMA. 2019;322(8):717. doi:10.1001/jama.2019.12351

Ketamine to Help Treat Cocaine Use Disorder

Abstract Full Text
JAMA. 2019;322(8):717. doi:10.1001/jama.2019.12352

Whole Food Combination Diet for Kids With Crohn Disease

Abstract Full Text
JAMA. 2019;322(8):717. doi:10.1001/jama.2019.12353

Antidepressants May Affect Pain Neural Network

Abstract Full Text
JAMA. 2019;322(8):717. doi:10.1001/jama.2019.12354
Health Agencies Update

Medicare Proposes Coverage of Acupuncture for Lower Back Pain

Abstract Full Text
JAMA. 2019;322(8):716. doi:10.1001/jama.2019.11573

Synchronizing Medication Refills Could Improve Adherence

Abstract Full Text
JAMA. 2019;322(8):716. doi:10.1001/jama.2019.12349

Botulinum Toxin to Treat Endometriosis Pain

Abstract Full Text
JAMA. 2019;322(8):716. doi:10.1001/jama.2019.12350
The Arts and Medicine

How to Fix the Premedical Curriculum—Another Try

Abstract Full Text
JAMA. 2019;322(8):710-711. doi:10.1001/jama.2019.11480

This Arts and Medicine feature reviews the case made by physician-essayist Lewis Thomas that all prospective medical students be required to know classical Greek language and literature before medical school acceptance and broadens the argument, calling on medical school admissions committees to require an undergraduate major in humanities as a basis for medical education.

Poetry and Medicine


Abstract Full Text
JAMA. 2019;322(8):787. doi:10.1001/jama.2019.5690
JAMA Revisited

Leonardo da Vinci as Anatomist (1452-1519)

Abstract Full Text
JAMA. 2019;322(8):788. doi:10.1001/jama.2018.15484
JAMA Patient Page

Chest Tubes

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JAMA. 2019;322(8):792. doi:10.1001/jama.2019.8842

This JAMA Patient Page describes reasons for use of chest tubes and the process of chest tube insertion and removal.

Comment & Response

Physicians’ Trust in Patients

Abstract Full Text
JAMA. 2019;322(8):782. doi:10.1001/jama.2019.9169

Physicians’ Trust in Patients—Reply

Abstract Full Text
JAMA. 2019;322(8):782-783. doi:10.1001/jama.2019.9200

PD-L1 Status and Survival in Patients With Lung Cancer

Abstract Full Text
JAMA. 2019;322(8):783. doi:10.1001/jama.2019.9177

PD-L1 Status and Survival in Patients With Lung Cancer—Reply

Abstract Full Text
JAMA. 2019;322(8):783-784. doi:10.1001/jama.2019.9196

Nutrition Education in Medical Training

Abstract Full Text
JAMA. 2019;322(8):784. doi:10.1001/jama.2019.9173

Nutrition Education in Medical Training—Reply

Abstract Full Text
JAMA. 2019;322(8):784-785. doi:10.1001/jama.2019.9192

Incorrect Axis Scale in Figure

Abstract Full Text
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JAMA. 2019;322(8):785. doi:10.1001/jama.2019.11467

Typographical Error in a Percentage in Figure

Abstract Full Text
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JAMA. 2019;322(8):785. doi:10.1001/jama.2019.11788
JAMA Masthead


Abstract Full Text
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JAMA. 2019;322(8):707-708. doi:10.1001/jama.2018.15477