April 7, 2020, Vol 323, No. 13, Pages 1223-1324

In This Issue of JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2020;323(13):e200015. doi:10.1001/jama.2020.0015

Audio Editors' Summary: Tenecteplase Before Stroke Thrombectomy, Celiac Disease and Mortality, USPSTF Guideline on BV Screening in Pregnancy, and more

Original Investigation

Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial

Bruce C. V. Campbell, PhD; Peter J. Mitchell, MMed; Leonid Churilov, PhD; et al.

Abstract Full Text

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JAMA. 2020;323(13):1257-1265. doi:10.1001/jama.2020.1511

This randomized clinical trial compares the effects of 2 tenecteplase doses (0.40 vs 0.25 mg/kg) prior to endovascular thrombectomy on blood flow restoration to brain ischemic territory in patients with large vessel occlusion ischemic stroke.

Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial

William D. Tap, MD; Andrew J. Wagner, MD, PhD; Patrick Schöffski, MD, PhD, MPH; et al.

Abstract Full Text

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JAMA. 2020;323(13):1266-1276. doi:10.1001/jama.2020.1707

This randomized trial compares the effect of doxorubicin plus olaratumab vs doxorubicin plus placebo on overall survival in patients with advanced/metastatic soft tissue sarcoma and leiomyosarcoma.

Editorial
Treatment for Advanced Soft Tissue Sarcoma: An Informative Neutral Trial
Christina L. Roland, MD, MS; Sandra L. Wong, MD, MS

Association Between Celiac Disease and Mortality Risk in a Swedish Population

Benjamin Lebwohl, MD, MS; Peter H. R. Green, MD; Jonas Söderling, PhD; et al.

Abstract Full Text

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JAMA. 2020;323(13):1277-1285. doi:10.1001/jama.2020.1943

This population epidemiology study used Swedish histopathology registry data to estimate mortality risk in patients with vs without celiac disease.

Research Letter

Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China

Min Wei, MD; Jingping Yuan, MD, PhD; Yu Liu, PhD; et al.

Abstract Full Text

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JAMA. 2020;323(13):1313-1314. doi:10.1001/jama.2020.2131

This study characterizes the demographic, epidemiologic, and clinical characteristics of hospitalized infants diagnosed with coronavirus disease 2019 infection between December 8, 2019, and February 6, 2020, in China.

Conversations with Dr Bauchner: COVID-19 Update From China

Editorial
Editorial Concern—Possible Reporting of the Same Patients With COVID-19 in Different Reports
Howard Bauchner, MD; Robert M. Golub, MD; Jody Zylke, MD

Medicare Enrollment Among Patients With End-Stage Kidney Disease Receiving Dialysis in Outpatient Facilities Between 2005 and 2016

Abby Hoffman, BA; Caroline E. Sloan, MD; Matthew L. Maciejewski, PhD; et al.

Abstract Full Text

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JAMA. 2020;323(13):1314-1316. doi:10.1001/jama.2020.0704

This study characterizes annual changes in enrollment of Medicare and non-Medicare patients treated at dialysis facilities before and after 2011 payment reforms and 2014 Affordable Care Act changes that influenced reimbursements.

US Preventive Services Task Force

Recommendation Statement

Screening for Bacterial Vaginosis in Pregnant Persons to Prevent Preterm Delivery: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force

Abstract Full Text

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JAMA. 2020;323(13):1286-1292. doi:10.1001/jama.2020.2684

This 2020 Recommendation Statement from the US Preventive Services Task Force recommends against screening for bacterial vaginosis (BV) in pregnant persons not at increased risk for preterm delivery (D recommendation) and concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for BV in pregnant persons at increased risk for preterm delivery (I statement).

Audio Author Interview: USPSTF Recommendation: Screening for Bacterial Vaginosis to Prevent Preterm Delivery

Editorial
USPSTF 2020 Recommendations on Screening for Asymptomatic Bacterial Vaginosis in Pregnancy
Amanda L. Lewis, PhD; Louise C. Laurent, MD, PhD
- Audio Author Interview: USPSTF Recommendation: Screening for Bacterial Vaginosis to Prevent Preterm Delivery

Evidence Report

Screening for Bacterial Vaginosis in Pregnant Adolescents and Women to Prevent Preterm Delivery: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Leila C. Kahwati, MD, MPH; Rachel Clark, BA; Nancy Berkman, PhD; et al.

Abstract Full Text

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JAMA. 2020;323(13):1293-1309. doi:10.1001/jama.2020.0233

This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on screening for bacterial vaginosis (BV) summarizes published evidence on the benefits and harms of BV screening and treatment in pregnant adolescents and adults to prevent preterm delivery.

Audio Author Interview: USPSTF Recommendation: Screening for Bacterial Vaginosis to Prevent Preterm Delivery

Editorial
USPSTF 2020 Recommendations on Screening for Asymptomatic Bacterial Vaginosis in Pregnancy
Amanda L. Lewis, PhD; Louise C. Laurent, MD, PhD
- Audio Author Interview: USPSTF Recommendation: Screening for Bacterial Vaginosis to Prevent Preterm Delivery

Viewpoint

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

Zunyou Wu, MD, PhD; Jennifer M. McGoogan, PhD

Abstract Full Text

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JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648

This Viewpoint summarizes key epidemiologic and clinical findings from all cases of coronavirus disease 2019 (COVID-19) reported through February 11, 2020, in mainland China, and case trends in response to government attempts to control and contain the infection.

Audio: COVID-19 Update With NIAID's Anthony Fauci, MD; March 6, 2020
Audio Clinical Review: Update on Coronavirus: March 6, 2020, by NIAID’s Anthony Fauci, MD

COVID-19 in Singapore—Current Experience: Critical Global Issues That Require Attention and Action

John E. L. Wong, MBBS; Yee Sin Leo, MBBS, MPH; Chorh Chuan Tan, MBBS, PhD

Abstract Full Text

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JAMA. 2020;323(13):1243-1244. doi:10.1001/jama.2020.2467

This Viewpoint discusses public health measures implemented in Singapore to manage potential COVID-19 infection based on the country’s experience with SARS in 2003 and reviews critical information gaps necessary to help manage the outbreak, such as viral shedding patterns and optimal timing of antiviral treatment after exposure.

Editorial
Editorial Concern—Possible Reporting of the Same Patients With COVID-19 in Different Reports
Howard Bauchner, MD; Robert M. Golub, MD; Jody Zylke, MD

Preparing for the Most Critically Ill Patients With COVID-19: The Potential Role of Extracorporeal Membrane Oxygenation

Graeme MacLaren, MSc; Dale Fisher, MBBS; Daniel Brodie, MD

Abstract Full Text

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JAMA. 2020;323(13):1245-1246. doi:10.1001/jama.2020.2342

This Viewpoint discusses the potential role of ECMO (extracorporeal membrane oxygenation) in the management of novel coronavirus disease 2019 (COVID-19) and cautions about the risk of overuse and the shortage of ECMO capability given the numbers of people infected if the technology is not appropriately utilized.

Audio Clinical Review: Update on Coronavirus: March 6, 2020, by NIAID’s Anthony Fauci, MD

A Low-Carbon Future Could Improve Global Health and Achieve Economic Benefits

Jonathan A. Patz, MD, MPH; Valerie J. Stull, PhD, MPH; Vijay S. Limaye, PhD

Abstract Full Text

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JAMA. 2020;323(13):1247-1248. doi:10.1001/jama.2020.1313

This Viewpoint proposes that framing climate change as a human health crisis could accelerate climate action, and reviews evidence pointing toward the health benefits of transitioning to renewable energy, plant-based diets, and a global lower carbon footprint.

Audio Author Interview: A Low-Carbon Future Could Improve Global Health and Save Money

A Piece of My Mind

The Peekaboo Visit

JoAnne Burger, MD

Abstract Full Text

JAMA. 2020;323(13):1249-1250. doi:10.1001/jama.2020.3211

In this narrative medicine essay, a pediatrician describes how a 2-year-old’s game of peekaboo expresses her bewilderment and grief at the death of her twin brother.

Editor's Note
Twins
Michael Berkwits, MD, MSCE

Editorial

Treatment for Advanced Soft Tissue Sarcoma: An Informative Neutral Trial

Christina L. Roland, MD, MS; Sandra L. Wong, MD, MS

Abstract Full Text

JAMA. 2020;323(13):1251-1252. doi:10.1001/jama.2020.0567

USPSTF 2020 Recommendations on Screening for Asymptomatic Bacterial Vaginosis in Pregnancy

Amanda L. Lewis, PhD; Louise C. Laurent, MD, PhD

Abstract Full Text

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JAMA. 2020;323(13):1253-1255. doi:10.1001/jama.2019.22311

Audio Author Interview: USPSTF Recommendation: Screening for Bacterial Vaginosis to Prevent Preterm Delivery

Editorial Concern—Possible Reporting of the Same Patients With COVID-19 in Different Reports

Howard Bauchner, MD; Robert M. Golub, MD; Jody Zylke, MD

Abstract Full Text

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JAMA. 2020;323(13):1256. doi:10.1001/jama.2020.3980

From The Medical Letter on Drugs and Therapeutics

Trifarotene (Aklief)—A New Topical Retinoid for Acne

Abstract Full Text

JAMA. 2020;323(13):1310-1311. doi:10.1001/jama.2019.22507

This Medical Letter review summarizes mechanisms of action and evidence of effects of Aklief, a 0.005% topical cream approved in 2019 for treatment of acne vulgaris in patients aged 9 years or older.

Editor's Note

Twins

Michael Berkwits, MD, MSCE

Abstract Full Text

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JAMA. 2020;323(13):1319. doi:10.1001/jama.2020.3895

Medical News & Perspectives

Confirmatory Trial for Drug to Prevent Preterm Birth Finds No Benefit, So Why Is It Still Prescribed?

Rita Rubin, MA

Abstract Full Text

JAMA. 2020;323(13):1229-1232. doi:10.1001/jama.2020.1486

This Medical News story examines the status of Makena, the only drug approved for the indication of preventing preterm birth.

Cardiovascular Corner—Stable Coronary Artery Disease, An LDL “Vaccine,” and Anti-inflammatories

Jennifer Abbasi

Abstract Full Text

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JAMA. 2020;323(13):1233-1234. doi:10.1001/jama.2019.20983

This Medical News series offers an occasional roundup of developments in cardiovascular medicine.

Audio: Live from AHA, Part 1: Highlights from the American Heart Association’s Scientific Sessions

Invited Commentary
Safety and Tolerability of Sustained Lipid-Lowering Therapy: Trial Data and Public Perception in a World Where Vaccines and Statins Are About to Collide
Maarten J. G. Leening, MD, PhD
- Audio Author Interview: Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels

News From the Food and Drug Administration

Another Targeted Therapy for Patients With Multiple Myeloma

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2020;323(13):1236. doi:10.1001/jama.2020.4039

Warning About Cleaning CPAP Devices With Ozone Gas, UV Light

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2020;323(13):1236. doi:10.1001/jama.2020.3728

Boxed Warning for Allergy Drug

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2020;323(13):1236. doi:10.1001/jama.2020.4040

Bench to Bedside

After Heart Attack, Growth Factor Improves Scar Quality and Heart Function in Pig Study

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2020;323(13):1235. doi:10.1001/jama.2020.1063

Poetry and Medicine

The Key

Sheila Gillooly Greene

Abstract Full Text

JAMA. 2020;323(13):1319. doi:10.1001/jama.2020.3424

Editor's Note
Twins
Michael Berkwits, MD, MSCE

JAMA Revisited

The Environment: A Death of Air

Abstract Full Text

JAMA. 2020;323(13):1320. doi:10.1001/jama.2019.13378

JAMA Patient Page

Screening for Bacterial Vaginosis During Pregnancy

Jill Jin, MD, MPH

Abstract Full Text

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JAMA. 2020;323(13):1324. doi:10.1001/jama.2020.3690

This JAMA Patient Page describes the US Preventive Services Task Force’s recent recommendations for screening for bacterial vaginosis during pregnancy.