This exploratory analysis of a randomized trial examined the effect of dapagliflozin on a composite of worsening heart failure or cardiovascular death on individuals with heart failure with reduced ejection fraction with and without diabetes.
This clinical trial tested whether the chikungunya virus–like particle vaccince was safe for participants living in chikungunya endemic areas.
This randomized trial compares preemptive therapy vs antiviral prophylaxis with valganciclovir in cytomegalovirus (CMV)-seronegative liver transplant recipients with seropositive donors for the prevention of CMV disease.
This study describes possible transmission of novel coronavirus disease 2019 (COVID-19) from an asymptomatic Wuhan resident to 5 family members in Anyang, a Chinese city in the neighboring province of Hubei.
This cross-sectional study uses data from a voluntary survey that was administered during the American College of Physicians Internal Medicine In-Training Examination to assess whether residents in programs with nocturnists perceived nighttime supervision differently than those in programs without nocturnists.
This Viewpoint provides an update on what’s known and not yet known about the coronavirus disease 2019 (COVID-19) epidemic, reviewing advances over the initial weeks of the outbreak in understanding the epidemiology and clinical spectrum of the illness and in approaches to diagnosis, management, and infection control.
This Viewpoint describes the outbreak response infrastructure developed by the Taiwanese government following the SARS epidemic in 2003 and actions in response to COVID-19, including dedicated hotlines for symptom reporting, mobile phone messaging and case tracking, and the ramping up of facemask production.
This Viewpoint discusses the preparedness plans that need to be implemented in the US to combat the SARS-CoV-2 virus (the cause of COVID-19 disease), including shoring up resources in hospitals and clinics, updating of triage and isolation protocols, expanding PCR manufacturing and patient testing, and communicating to the public with unified public health messages.
This Viewpoint discusses the importance of shared decision-making (SDM) for providing care that takes into account the experience, expertise, and specific situations of patients; and stresses the importance of developing clinical practice guidelines that consider known barriers and costs of SDM implementation and when SDM is most relevant and useful.
In this narrative medicine essay, a neonatologist struggles with the perfectionism she cultivated during her pediatric training in knowing how to help her son’s constipation and in the process learns true compassion for patients’ families.
This review provides an update on the epidemiology, pathophysiology, diagnosis, and management of obstructive sleep apnea, including the incorporation of questions regarding snoring, breathing pauses at night, and excessive fatigue or sleepiness during the day at routine clinician visits and the increased use of home sleep apnea testing rather than in-hospital testing for diagnostic purposes.
This JAMA Guide to Statistics and Methods explains the meaning underlying the proportional hazards (PH) assumption underlying Cox regression and survival analyses, and proposes that reports of survival differences might replace statistical tests of the PH assumption because they are more meaningful.
This JAMA Insights Clinical Update summarizes updated evidence regarding diagnosis and management of Clostridioides (formerly Clostridium) difficile infection (CDI) in adults, including review of new toxin detection assays and biologic treatments.
This Medical News article discusses programs that enable more American Indian/Alaska Native students to enter medical school.
Matters of the Mind offers an occasional look at recent research into the relationship between the mind and the body.
This JAMA Patient Page describes treatment options for individuals with Parkinson disease.
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