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June 2021 - July 1883




April 14, 2020, Vol 323, No. 14, Pages 1327-1420

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2020;323(14):e200016. doi:10.1001/jama.2020.0016
Original Investigation

Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes

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JAMA. 2020;323(14):1353-1368. doi:10.1001/jama.2020.1906

This exploratory analysis of a randomized trial examined the effect of dapagliflozin on a composite of worsening heart failure or cardiovascular death on individuals with heart failure with reduced ejection fraction with and without diabetes.

Effect of a Chikungunya Virus–Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial

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JAMA. 2020;323(14):1369-1377. doi:10.1001/jama.2020.2477

This clinical trial tested whether the chikungunya virus–like particle vaccince was safe for participants living in chikungunya endemic areas.

Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors: A Randomized Clinical Trial

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JAMA. 2020;323(14):1378-1387. doi:10.1001/jama.2020.3138

This randomized trial compares preemptive therapy vs antiviral prophylaxis with valganciclovir in cytomegalovirus (CMV)-seronegative liver transplant recipients with seropositive donors for the prevention of CMV disease.

Research Letter

Presumed Asymptomatic Carrier Transmission of COVID-19

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JAMA. 2020;323(14):1406-1407. doi:10.1001/jama.2020.2565

This study describes possible transmission of novel coronavirus disease 2019 (COVID-19) from an asymptomatic Wuhan resident to 5 family members in Anyang, a Chinese city in the neighboring province of Hubei.

Association Between Nocturnist Supervision and Perceived Overnight Supervision Adequacy Among Internal Medicine Residents in the US

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JAMA. 2020;323(14):1407-1409. doi:10.1001/jama.2020.0875

This cross-sectional study uses data from a voluntary survey that was administered during the American College of Physicians Internal Medicine In-Training Examination to assess whether residents in programs with nocturnists perceived nighttime supervision differently than those in programs without nocturnists.


COVID-19—New Insights on a Rapidly Changing Epidemic

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JAMA. 2020;323(14):1339-1340. doi:10.1001/jama.2020.3072

This Viewpoint provides an update on what’s known and not yet known about the coronavirus disease 2019 (COVID-19) epidemic, reviewing advances over the initial weeks of the outbreak in understanding the epidemiology and clinical spectrum of the illness and in approaches to diagnosis, management, and infection control.

Response to COVID-19 in Taiwan: Big Data Analytics, New Technology, and Proactive Testing

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JAMA. 2020;323(14):1341-1342. doi:10.1001/jama.2020.3151

This Viewpoint describes the outbreak response infrastructure developed by the Taiwanese government following the SARS epidemic in 2003 and actions in response to COVID-19, including dedicated hotlines for symptom reporting, mobile phone messaging and case tracking, and the ramping up of facemask production.

Priorities for the US Health Community Responding to COVID-19

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JAMA. 2020;323(14):1343-1344. doi:10.1001/jama.2020.3413

This Viewpoint discusses the preparedness plans that need to be implemented in the US to combat the SARS-CoV-2 virus (the cause of COVID-19 disease), including shoring up resources in hospitals and clinics, updating of triage and isolation protocols, expanding PCR manufacturing and patient testing, and communicating to the public with unified public health messages.

When Guidelines Recommend Shared Decision-making

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JAMA. 2020;323(14):1345-1346. doi:10.1001/jama.2020.1525

This Viewpoint discusses the importance of shared decision-making (SDM) for providing care that takes into account the experience, expertise, and specific situations of patients; and stresses the importance of developing clinical practice guidelines that consider known barriers and costs of SDM implementation and when SDM is most relevant and useful.

A Piece of My Mind


Abstract Full Text
JAMA. 2020;323(14):1347-1348. doi:10.1001/jama.2020.3540

In this narrative medicine essay, a neonatologist struggles with the perfectionism she cultivated during her pediatric training in knowing how to help her son’s constipation and in the process learns true compassion for patients’ families.


A Novel Cardioprotective Therapy That Also Improves Glycemia

Abstract Full Text
JAMA. 2020;323(14):1349-1350. doi:10.1001/jama.2020.1905

A New Vaccine for Chikungunya Virus

Abstract Full Text
JAMA. 2020;323(14):1351-1352. doi:10.1001/jama.2020.2070

Diagnosis and Management of Obstructive Sleep Apnea: A Review

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JAMA. 2020;323(14):1389-1400. doi:10.1001/jama.2020.3514

This review provides an update on the epidemiology, pathophysiology, diagnosis, and management of obstructive sleep apnea, including the incorporation of questions regarding snoring, breathing pauses at night, and excessive fatigue or sleepiness during the day at routine clinician visits and the increased use of home sleep apnea testing rather than in-hospital testing for diagnostic purposes.

JAMA Guide to Statistics and Methods

Why Test for Proportional Hazards?

Abstract Full Text
JAMA. 2020;323(14):1401-1402. doi:10.1001/jama.2020.1267

This JAMA Guide to Statistics and Methods explains the meaning underlying the proportional hazards (PH) assumption underlying Cox regression and survival analyses, and proposes that reports of survival differences might replace statistical tests of the PH assumption because they are more meaningful.

JAMA Insights

Clinical Update

Diagnosis and Treatment of Clostridioides (Clostridium) difficile Infection in Adults in 2020

Abstract Full Text
JAMA. 2020;323(14):1403-1404. doi:10.1001/jama.2019.3849

This JAMA Insights Clinical Update summarizes updated evidence regarding diagnosis and management of Clostridioides (formerly Clostridium) difficile infection (CDI) in adults, including review of new toxin detection assays and biologic treatments.

Editor's Note

Preventing Cytomegalovirus Infection After Liver Transplant: An Evolving Approach

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JAMA. 2020;323(14):1388. doi:10.1001/jama.2020.3596
Medical News & Perspectives

Boosting the Ranks of American Indian and Alaska Native Physicians

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JAMA. 2020;323(14):1330-1332. doi:10.1001/jama.2020.2349

This Medical News article discusses programs that enable more American Indian/Alaska Native students to enter medical school.

Matters of the Mind—Sleep Medications and Dementia Risk, Depression and Weight Gain, Opioids and Mental Disorders

Abstract Full Text
JAMA. 2020;323(14):1333-1334. doi:10.1001/jama.2020.1836

Matters of the Mind offers an occasional look at recent research into the relationship between the mind and the body.

News From the Centers for Disease Control and Prevention

Legionnaires Disease Death Linked to Home Water Contamination

Abstract Full Text
JAMA. 2020;323(14):1337. doi:10.1001/jama.2020.3495

US-Acquired Chagas Disease Case Found After Blood Donation

Abstract Full Text
JAMA. 2020;323(14):1337. doi:10.1001/jama.2020.4294
Biotech Innovations

Alzheimer Blood Test Using Tau Biomarker Is in Development

Abstract Full Text
JAMA. 2020;323(14):1336. doi:10.1001/jama.2020.4542

FLU-v, a Universal Flu Vaccine Candidate, Advances in Trial

Abstract Full Text
JAMA. 2020;323(14):1336. doi:10.1001/jama.2020.4138

Artificial Intelligence–Based Skin Cancer Phone Apps Unreliable

Abstract Full Text
JAMA. 2020;323(14):1336. doi:10.1001/jama.2020.4543
JAMA Infographic

Coronavirus Disease 2019 (COVID-19) in Italy

Abstract Full Text
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JAMA. 2020;323(14):1335. doi:10.1001/jama.2020.4344
Poetry and Medicine


Abstract Full Text
JAMA. 2020;323(14):1413. doi:10.1001/jama.2020.0135
JAMA Revisited

The Prevailing Pandemic of Influenza

Abstract Full Text
JAMA. 2020;323(14):1414-1415. doi:10.1001/jama.2020.4357
JAMA Patient Page

Choosing a Parkinson Disease Treatment

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JAMA. 2020;323(14):1420. doi:10.1001/jama.2020.1224

This JAMA Patient Page describes treatment options for individuals with Parkinson disease.

Comment & Response

Suicides Among Opioid Overdose Deaths

Abstract Full Text
JAMA. 2020;323(14):1409-1410. doi:10.1001/jama.2020.1446

Suicides Among Opioid Overdose Deaths—Reply

Abstract Full Text
JAMA. 2020;323(14):1410-1411. doi:10.1001/jama.2020.1458

Kidney Function in Patients With Type 2 Diabetes After Vitamin D Supplementation

Abstract Full Text
JAMA. 2020;323(14):1411. doi:10.1001/jama.2020.1391

Kidney Function in Patients With Type 2 Diabetes After Vitamin D Supplementation—Reply

Abstract Full Text
JAMA. 2020;323(14):1411-1412. doi:10.1001/jama.2020.1400
JAMA Masthead


Abstract Full Text
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JAMA. 2020;323(14):1327-1328. doi:10.1001/jama.2019.13382