This randomized trial compares the effects of apabetalone (an inhibitor of bromodomain 2 and extraterminal protein, 2 epigenetic “readers”) vs placebo on major adverse cardiovascular events in patients with acute coronary syndrome (ACS), type 2 diabetes, and low HDL cholesterol level.
This case series describes the demographics, comorbidities, ventilation requirements, dispositions, and mortality of patients with PCR-confirmed SARS-CoV-2 infection admitted to northern Italy ICUs in February-March 2020..
This case series describes clinical outcomes in 5 Chinese patients with laboratory-confirmed COVID-19, ARDS, and high viral loads despite antiviral treatment who were given human plasma with SARS-CoV-2 antibodies obtained from previously infected and recovered patients.
This study documents results of SARS-CoV-2 polymerase chain reaction (PCR) testing of environmental surfaces and personal protective equipment surrounding 3 COVID-19 patients in isolation rooms in a Singapore hospital.
This case series describes the clinical presentation, characteristics, and outcomes of patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit at a public hospital in Washington State in February 2020, including initial reports of cardiomyopathy in one-third of the patients.
This study uses data from the publicly available Centers for Medicare & Medicaid Services (CMS) Inventory Tool to determine the proportion of CMS quality measures that are used or finalized for use in a CMS program, under development or consideration for use, or not in use.
This 2020 Recommendation Statement from the US Preventive Services Task Force recommends that primary care clinicians provide interventions, including education or brief counseling, to prevent initiation of tobacco use among school-aged children and adolescents (B recommendation) and concludes that current evidence is insufficient to assess the benefits and harms of primary care interventions for cessation of tobacco use among school-aged children and adolescents (I statement).
This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on interventions for prevention and cessation of tobacco and nicotine use summarizes published evidence on the benefits and harms of primary care–relevant interventions for tobacco and nicotine use prevention and cessation in children and adolescents.
This Viewpoint describes the organization of a regional ICU network in Lombardy, Italy, to handle the surge in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who require intensive care and uses demand experience in the first 2 weeks of the outbreak to estimate resources required in coming weeks.
This Viewpoint reviews legal powers the US president and state governors have to implement travel and other restrictions to control the spread of coronavirus, and discusses the need to balance rights to privacy and liberty with public health in ways that do not disadvantage already vulnerable populations.
This Viewpoint discusses challenges to managing a COVID-19 outbreak in low- and middle-income countries (LMICs), reviewing how absence of testing, critical care capacity, climate, war, distrust, and large refugee populations could complicate implementation of proven infection prevention and control measures.
This Viewpoint acknowledges that physicians in clinical roles may be limited in their ability to influence social determinants of patients’ health but proposes they have a role to play in educating others of its importance through teaching and training, diverse student and workforce recruitment, and activism.
This Viewpoint introduces the notion of a polysocial risk score, much like a polygenic risk score, which might help predict the risk that varying combinations of social conditions contribute to specific health outcomes.
In this narrative medicine essay, a resident physician with asthma describes her internal deliberations about public vs private good after a decision to retreat from direct-patient care to telemedicine to protect her health during the coronavirus pandemic.
This Medical News article discusses the first human genome editing studies using CRISPR-Cas9.
This Medical News article discusses a recent review of 17 clinical trials comparing the effects of coconut oil and other vegetable oils on cardiovascular disease risk factors.
This JAMA Patient Page describes the US Preventive Services Task Force’s recent recommendations for prevention and cessation of tobacco use in children and adolescents.