This randomized trial compares the effects of open reduction and internal fixation vs functional bracing for treating patients with closed displaced humeral shaft fractures.
This randomized trial compares the effect of shoes with adjustable external convex pods attached to the outsole vs usual footwear on knee pain over 24 weeks in patients with symptomatic, radiologically confirmed knee osteoarthritis.
This inception cohort study uses Medicare fee-for-service claims data to assess the association between initiation of pulmonary rehabilitation within 90 days of hospital discharge and 1-year survival among US patients hospitalized for chronic obstructive pulmonary disease in 2014.
This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify possible means of non-respiratory transmission.
This study reviews research ethics committee applications for COVID-19–related research at a Chinese hospital in February 2020 to characterize study type, approval rate and review time, reason for revision or denial, and issues with informed consent.
This case report describes birth of an infant with elevated anti–SARS-CoV-2 IgM antibodies and cytokine levels to a mother with polymerase chain reaction–confirmed coronavirus disease 2019 (COVID-19) despite no physical contact.
This study describes results of IgM and IgG antibody testing from throat swabs of newborns born to mothers with COVID-19 pneumonia.
This study examines the feasibility of rapidly training and fit testing health care workers to use elastomeric half-mask respirators (EHMRs), widely used in construction and manufacturing, as an alternative to N95 respirators during periods of shortage.
This study used data from the US Centers for Disease Control and Prevention WONDER database to examined temporal trends in cardiovascular disease age-adjusted mortality rates overall and across subgroups stratified by rural-urban area designation in the US.
This Viewpoint provides a summary update of coronavirus disease 2019 (COVID-19) in the US, discussing case-fatality rates, interpretation of polymerase chain reaction test results, duration of immunity, reinfection, and more.
This Viewpoint reviews the pathophysiological and observational basis for speculating that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) might worsen clinical outcomes for patients with COVID-19, and summarizes guidance from specialty societies to continue the drugs in patients who need them pending more definitive evidence of harm.
This Viewpoint emphasizes the importance of advanced care planning and goals-of-care discussions with older patients and those with chronic disease during the spread of coronavirus disease (COVID-19), given the likelihood these patients could become critically ill and require resuscitation and advanced life support if they became infected with SARS-CoV-2.
This Viewpoint describes a framework for rationing ventilators during the COVID-19 pandemic should intensive care units find themselves with more patients than they can care for, using a score-based system that incorporates patients’ likelihood of surviving to hospital discharge and beyond and their role in the public health response to the outbreak.
This Viewpoint from physicians with the Italian National Institute of Health confirms a higher case-fatality rate from coronavirus disease 2019 (COVID-19) in Italy compared with China and explains possible reasons, including age, cause of death definitions, and testing strategy.
This Viewpoint summarizes the distribution of physicians and registered nurses aged 55 years and older in US cities caring for COVID-19 patients and proposes roles they can play in health systems that preserve their ability to apply their experience over the long-term course of the pandemic.
This Viewpoint discusses the unintended adverse consequences of delayed antibiotic prescribing—provision of an antibiotic prescription to be filled at a later date if a patient’s condition has not improved—and calls on clinicians to avoid the practice in patients who have self-limited conditions with likely viral etiologies.
In this narrative medicine essay, a pediatric psychiatrist relates how her younger sister with Down syndrome and congenital heart disease has lived well beyond expectation inspired her to help children cultivate hope through love and resilience.
This narrative review summarizes what is currently known about how SARS-CoV-2 infects cells and causes disease as a basis for considering whether chloroquine, remdisivir and other antivirals, or other existing drugs might be effective treatment for coronavirus disease 2019 (COVID-19).
This JAMA Insights Clinical Update discusses the need to better understand the dynamics of respiratory disease transmission by better characterizing transmission routes, the role of patient physiology in shaping them, and best approaches for source control in the context of the COVID-19 outbreak.
This JAMA Clinical Guidelines Synopsis summarizes the 2020 Surviving Sepsis Campaign guidelines on the treatment of critically ill adults with coronavirus disease 2019 (COVID-19).
This Medical News feature examines steps that correctional facilities are taking to minimize the spread of COVID-19.
This Arts and Medicine feature draws lessons from William Shakespeare’s King Lear about our collective disorientation and obligations to each other in the midst of the first-wave coronavirus (COVID-19) pandemic.
This JAMA Patient Page describes the symptoms, prevention, diagnosis, and treatment of hepatitis E.